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Decreased Neutrophi...
Decreased Neutrophil Extracellular Trap Degradation in Shiga Toxin-Associated Haemolytic Uraemic Syndrome
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- Leffler, Jonatan (author)
- Lund University,Lunds universitet,Proteinkemi, Malmö,Forskargrupper vid Lunds universitet,Protein Chemistry, Malmö,Lund University Research Groups,University of Western Australia, Crawley
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- Prohászka, Zoltán (author)
- Semmelweis University
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- Mikes, Bálint (author)
- Semmelweis University
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- Sinkovits, György (author)
- Semmelweis University
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- Ciacma, Katarzyna (author)
- Lund University,Lunds universitet,Proteinkemi, Malmö,Forskargrupper vid Lunds universitet,Protein Chemistry, Malmö,Lund University Research Groups
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- Farkas, Péter (author)
- Semmelweis University
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- Réti, Marienn (author)
- St. István and St. László Hospital of Budapest
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- Kelen, Kata (author)
- Semmelweis University
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- Reusz, György S. (author)
- Semmelweis University
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- Szabó, Attila J. (author)
- Semmelweis University
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- Martin, Myriam (author)
- Lund University,Lunds universitet,Proteinkemi, Malmö,Forskargrupper vid Lunds universitet,Protein Chemistry, Malmö,Lund University Research Groups
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- Blom, Anna M. (author)
- Lund University,Lunds universitet,Proteinkemi, Malmö,Forskargrupper vid Lunds universitet,Protein Chemistry, Malmö,Lund University Research Groups
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(creator_code:org_t)
- 2016-10-27
- 2017
- English.
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In: Journal of Innate Immunity. - : S. Karger AG. - 1662-811X .- 1662-8128. ; 9:1, s. 12-21
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Abstract
Subject headings
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- Background: Neutrophil extracellular traps (NETs) can stimulate thrombosis, and their degradation is decreased in several autoimmune disorders. It was recently reported that some patients with haemolytic uraemic syndrome (HUS) also fail to degrade NETs and that neutrophils from Shiga toxin-associated HUS are primed to form NETs. Method: We used a well-characterized cohort of 74 thrombotic microangiopathy (TMA) patients, with a subset also providing follow-up samples, and 112 age-matched controls to investigate NET degradation and serum nuclease activity in TMA before, during and after treatment. Results: We identified that in the cohort of TMA patients, 50% of patients with Shiga toxin-associated HUS displayed a decreased ability to degrade NETs. NET degradation correlated with serum nuclease activity, but not with autoantibodies against double-stranded DNA, which has been previously observed in some autoimmune disorders. Further, NET degradation negatively correlated with serum creatinine levels, suggesting that kidney function was negatively impacted by the low NET degradation ability. Conclusions: We revealed that decreased NET degradation is a common feature of Shiga toxin-associated HUS and that it is associated with decreased kidney function in these patients. It remains to be clarified whether improving NET degradation would be beneficial for the patient.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Degradation
- Kidney injury
- Neutrophil extracellular traps
- Nuclease activity
- Shiga toxin-associated haemolytic uraemic syndrome
- Thrombotic microangiopathies
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Leffler, Jonatan
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Prohászka, Zoltá ...
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Mikes, Bálint
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Sinkovits, Györg ...
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Ciacma, Katarzyn ...
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Farkas, Péter
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show more...
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Réti, Marienn
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Kelen, Kata
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Reusz, György S.
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Szabó, Attila J.
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Martin, Myriam
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Blom, Anna M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Journal of Innat ...
- By the university
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Lund University