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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02123naa a2200313 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:146549297 | |
| 003 | SwePub | |
| 008 | 240701s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1465492972 URI |
| 024 | 7 | a https://doi.org/10.3390/ijms220945302 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Gao, Yu Karolinska Institutet4 aut |
| 245 | 1 0 | a Live Cell FRET Imaging Reveals Amyloid β-Peptide Oligomerization in Hippocampal Neurons |
| 264 | c 2021-04-26 | |
| 264 | 1 | b MDPI AG,c 2021 |
| 520 | a Amyloid β-peptide (Aβ) oligomerization is believed to contribute to the neuronal dysfunction in Alzheimer disease (AD). Despite decades of research, many details of Aβ oligomerization in neurons still need to be revealed. Förster resonance energy transfer (FRET) is a simple but effective way to study molecular interactions. Here, we used a confocal microscope with a sensitive Airyscan detector for FRET detection. By live cell FRET imaging, we detected Aβ42 oligomerization in primary neurons. The neurons were incubated with fluorescently labeled Aβ42 in the cell culture medium for 24 h. Aβ42 were internalized and oligomerized in the lysosomes/late endosomes in a concentration-dependent manner. Both the cellular uptake and intracellular oligomerization of Aβ42 were significantly higher than for Aβ40. These findings provide a better understanding of Aβ42 oligomerization in neurons. | |
| 700 | 1 | a Wennmalm, S4 aut |
| 700 | 1 | a Winblad, Bu Karolinska Institutet4 aut |
| 700 | 1 | a Schedin-Weiss, Su Karolinska Institutet4 aut |
| 700 | 1 | a Tjernberg, LOu Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t International journal of molecular sciencesd : MDPI AGg 22:9q 22:9x 1422-0067 |
| 856 | 4 | u https://www.mdpi.com/1422-0067/22/9/4530/pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:146549297 |
| 856 | 4 8 | u https://doi.org/10.3390/ijms22094530 |
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