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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004970naa a2200493 4500
001oai:gup.ub.gu.se/287662
003SwePub
008240528s2019 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:d38ae371-d4fc-4ac1-ac4f-39637515d059
0247 a https://gup.ub.gu.se/publication/2876622 URI
0247 a https://doi.org/10.1038/s41598-019-54204-z2 DOI
0247 a https://lup.lub.lu.se/record/d38ae371-d4fc-4ac1-ac4f-39637515d0592 URI
040 a (SwePub)gud (SwePub)lu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Blennow, Kaj,d 1958u University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital4 aut0 (Swepub:lu)med-kbw
2451 0a Predicting clinical decline and conversion to Alzheimer's disease or dementia using novel Elecsys Aβ(1-42), pTau and tTau CSF immunoassays.
264 c 2019-12-13
264 1b Springer Science and Business Media LLC,c 2019
520 a We evaluated the performance of CSF biomarkers for predicting risk of clinical decline and conversion to dementia in non-demented patients with cognitive symptoms. CSF samples from patients in two multicentre longitudinal studies (ADNI, n=619; BioFINDER, n=431) were analysed. Aβ(1-42), tTau and pTau CSF concentrations were measured using Elecsys CSF immunoassays, and tTau/Aβ(1-42) and pTau/Aβ(1-42) ratios calculated. Patients were classified as biomarker (BM)-positive or BM-negative at baseline. Ability of biomarkers to predict risk of clinical decline and conversion to AD/dementia was assessed using pre-established cut-offs for Aβ(1-42) and ratios; tTau and pTau cut-offs were determined. BM-positive patients showed greater clinical decline than BM-negative patients, demonstrated by greater decreases in MMSE scores (all biomarkers: -2.10 to -0.70). Risk of conversion to AD/dementia was higher in BM-positive patients (HR: 1.67to11.48). Performance of Tau/Aβ(1-42) ratios was superior to single biomarkers, and consistent even when using cut-offs derived in a different cohort. Optimal pTau and tTau cut-offs were approximately 27pg/mL and 300pg/mL in both BioFINDER and ADNI. Elecsys pTau/Aβ(1-42) and tTau/Aβ(1-42) are robust biomarkers for predicting risk of clinical decline and conversion to dementia in non-demented patients, and may support AD diagnosis in clinical practice.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
7001 a Shaw, Leslie Mu University of Pennsylvania4 aut
7001 a Stomrud, Eriku Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-esr
7001 a Mattsson, Niklasu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Medicinska fakulteten,Clinical Memory Research,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-nmn
7001 a Toledo, Jon Bu University of Pennsylvania,Methodist Hospital Houston4 aut
7001 a Buck, Katharinau Roche Diagnostics, Germany4 aut
7001 a Wahl, Simoneu Roche Diagnostics, Germany4 aut
7001 a Eichenlaub, Udou Roche Diagnostics, Germany4 aut
7001 a Lifke, Valeriau Roche Diagnostics, Germany4 aut
7001 a Simon, Marylineu Roche Diagnostics International4 aut
7001 a Trojanowski, John Qu University of Pennsylvania4 aut
7001 a Hansson, Oskaru Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)mphy-ohn
7102 a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
7730 t Scientific reportsd : Springer Science and Business Media LLCg 9:1q 9:1x 2045-2322
8564 u https://www.nature.com/articles/s41598-019-54204-z.pdf
8564 u http://dx.doi.org/10.1038/s41598-019-54204-zx freey FULLTEXT
8564 8u https://gup.ub.gu.se/publication/287662
8564 8u https://doi.org/10.1038/s41598-019-54204-z
8564 8u https://lup.lub.lu.se/record/d38ae371-d4fc-4ac1-ac4f-39637515d059

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