WFRF:(Van der Merwe S)
Sökning: WFRF:(Van der Merwe S) > Hepatocyte MyD88 af...
- 12 av 26
- Föregående post
- Nästa post
- Till träfflistan
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04752naa a2200637 4500 | |
| 001 | oai:gup.ub.gu.se/251606 | |
| 003 | SwePub | |
| 008 | 240528s2017 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2516062 URI |
| 024 | 7 | a https://doi.org/10.1136/gutjnl-2015-3109042 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Duparc, T.4 aut |
| 245 | 1 0 | a Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism |
| 264 | c 2016-05-05 | |
| 264 | 1 | b BMJ,c 2017 |
| 520 | a Objective To examine the role of hepatocyte myeloid differentiation primary-response gene 88 (MyD88) on glucose and lipid metabolism. Design To study the impact of the innate immune system at the level of the hepatocyte and metabolism, we generated mice harbouring hepatocyte-specific deletion of MyD88. We investigated the impact of the deletion on metabolism by feeding mice with a normal control diet or a high-fat diet for 8 weeks. We evaluated body weight, fat mass gain (using time-domain nuclear magnetic resonance), glucose metabolism and energy homeostasis (using metabolic chambers). We performed microarrays and quantitative PCRs in the liver. In addition, we investigated the gut microbiota composition, bile acid profile and both liver and plasma metabolome. We analysed the expression pattern of genes in the liver of obese humans developing nonalcoholic steatohepatitis (NASH). Results Hepatocyte-specific deletion of MyD88 predisposes to glucose intolerance, inflammation and hepatic insulin resistance independently of body weight and adiposity. These phenotypic differences were partially attributed to differences in gene expression, transcriptional factor activity (ie, peroxisome proliferator activator receptor-alpha, farnesoid X receptor (FXR), liver X receptors and STAT3) and bile acid profiles involved in glucose, lipid metabolism and inflammation. In addition to these alterations, the genetic deletion of MyD88 in hepatocytes changes the gut microbiota composition and their metabolomes, resembling those observed during diet-induced obesity. Finally, obese humans with NASH displayed a decreased expression of different cytochromes P450 involved in bioactive lipid synthesis. Conclusions Our study identifies a new link between innate immunity and hepatic synthesis of bile acids and bioactive lipids. This dialogue appears to be involved in the susceptibility to alterations associated with obesity such as type 2 diabetes and NASH, both in mice and humans. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
| 653 | a proliferator-activated-receptor | |
| 653 | a diet-induced obesity | |
| 653 | a fatty | |
| 653 | a liver-disease | |
| 653 | a farnesoid x-receptor | |
| 653 | a large gene lists | |
| 653 | a insulin-resistance | |
| 653 | a epoxyeicosatrienoic acids | |
| 653 | a adipose-tissue | |
| 653 | a intestinal microbiota | |
| 653 | a mice | |
| 653 | a Gastroenterology & Hepatology | |
| 700 | 1 | a Plovier, H.4 aut |
| 700 | 1 | a Marrachelli, V. G.4 aut |
| 700 | 1 | a Van Hul, M.4 aut |
| 700 | 1 | a Essaghir, A.4 aut |
| 700 | 1 | a Ståhlman, Marcus,d 1975u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xstahm |
| 700 | 1 | a Matamoros, S.4 aut |
| 700 | 1 | a Geurts, L.4 aut |
| 700 | 1 | a Pardo-Tendero, M. M.4 aut |
| 700 | 1 | a Druart, C.4 aut |
| 700 | 1 | a Delzenne, N. M.4 aut |
| 700 | 1 | a Demoulin, J. B.4 aut |
| 700 | 1 | a van der Merwe, S. W.4 aut |
| 700 | 1 | a van Pelt, J.4 aut |
| 700 | 1 | a Bäckhed, Fredrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory4 aut0 (Swepub:gu)xbafre |
| 700 | 1 | a Monleon, D.4 aut |
| 700 | 1 | a Everard, A.4 aut |
| 700 | 1 | a Cani, P. D.4 aut |
| 710 | 2 | a Göteborgs universitetb Wallenberglaboratoriet4 org |
| 773 | 0 | t Gutd : BMJg 66:4, s. 620-632q 66:4<620-632x 0017-5749x 1468-3288 |
| 856 | 4 | u https://gut.bmj.com/content/gutjnl/66/4/620.full.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/251606 |
| 856 | 4 8 | u https://doi.org/10.1136/gutjnl-2015-310904 |
- 12 av 26
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Duparc, T.
- Plovier, H.
- Marrachelli, V. ...
- Van Hul, M.
- Essaghir, A.
- Ståhlman, Marcus ...
- visa fler...
- Matamoros, S.
- Geurts, L.
- Pardo-Tendero, M ...
- Druart, C.
- Delzenne, N. M.
- Demoulin, J. B.
- van der Merwe, S ...
- van Pelt, J.
- Bäckhed, Fredrik ...
- Monleon, D.
- Everard, A.
- Cani, P. D.
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Gastroenterologi
- Artiklar i publikationen
- Gut
- Av lärosätet
- Göteborgs universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
