GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients

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Fältnamn	Indikatorer	Metadata
000		06064naa a2200601 4500
001		oai:DiVA.org:uu-390688
003		SwePub
008		190814s2019 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:141219256
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3906882 URI
024	7	a https://doi.org/10.7554/eLife.471782 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1412192562 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Hu, Xuchenu Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA4 aut
245	1 0	a GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients
264	1	b ELIFE SCIENCES PUBLICATIONS LTD,c 2019
338		a electronic2 rdacarrier
520		a GPIHBP1, a GPI-anchored protein of capillary endothelial cells, binds lipoprotein lipase (LPL) within the subendothelial spaces and shuttles it to the capillary lumen. GPIHBP1-bound LPL is essential for the margination of triglyceride-rich lipoproteins (TRLs) along capillaries, allowing the lipolytic processing of TRLs to proceed. In peripheral tissues, the intravascular processing of TRLs by the GPIHBP1-LPL complex is crucial for the generation of lipid nutrients for adjacent parenchymal cells. GPIHBP1 is absent from the capillaries of the brain, which uses glucose for fuel; however, GPIHBP1 is expressed in the capillaries of mouse and human gliomas. Importantly, the GPIHBP1 in glioma capillaries captures locally produced LPL. We use NanoSIMS imaging to show that TRLs marginate along glioma capillaries and that there is uptake of TRL-derived lipid nutrients by surrounding glioma cells. Thus, GPIHBP1 expression in gliomas facilitates TRL processing and provides a source of lipid nutrients for glioma cells.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng
700	1	a Matsumoto, Kenu VIB KU Leuven Ctr Canc Biol CCB, Leuven, Belgium4 aut
700	1	a Jung, Rachel S.u Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA4 aut
700	1	a Weston, Thomas A.u Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA4 aut
700	1	a Heizer, Patrick J.u Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA4 aut
700	1	a He, Cuiwenu Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA4 aut
700	1	a Sandoval, Norma P.u Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA4 aut
700	1	a Allan, Christopher M.u Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA4 aut
700	1	a Tu, Yipingu Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA4 aut
700	1	a Vinters, Harry V.u Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA4 aut
700	1	a Liau, Linda M.u Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurosurg, Los Angeles, CA 90095 USA;Univ Calif Los Angeles, David Geffen Sch Med, JCCC, Los Angeles, CA 90095 USA4 aut
700	1	a Ellison, Rochelle M.u Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA4 aut
700	1	a Morales, Jazmin E.u Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA4 aut
700	1	a Baufeld, Lynn J.u Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA;Univ Calif Los Angeles, David Geffen Sch Med, Ahmanson Translat Imaging Div, Los Angeles, CA 90095 USA4 aut
700	1	a Bayley, Nicholas A.u Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA;Univ Calif Los Angeles, David Geffen Sch Med, Ahmanson Translat Imaging Div, Los Angeles, CA 90095 USA4 aut
700	1	a He, Liqunu Uppsala universitet,Vaskulärbiologi4 aut0 (Swepub:uu)liqhe592
700	1	a Betsholtz, Christeru Karolinska Institutet,Uppsala universitet,Vaskulärbiologi,Integrated Cardio Metabolic Centre (ICMC), Karolinska Institutet, Huddinge, Sweden4 aut0 (Swepub:uu)chbet517
700	1	a Beigneux, Anne P., Iu Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA4 aut
700	1	a Nathanson, David A.u Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA;Univ Calif Los Angeles, David Geffen Sch Med, Ahmanson Translat Imaging Div, Los Angeles, CA 90095 USA4 aut
700	1	a Gerhardt, Holgeru VIB KU Leuven Ctr Canc Biol CCB, Leuven, Belgium;Max Delbruck Ctr Mol Med, Berlin, Germany4 aut
700	1	a Young, Stephen G.u Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA;Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA4 aut
700	1	a Fong, Loren G.u Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA4 aut
700	1	a Jian, Haibou Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA;Univ Western Australia, Sch Mol Sci, Perth, WA, Australia4 aut
710	2	a Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USAb VIB KU Leuven Ctr Canc Biol CCB, Leuven, Belgium4 org
773	0	t eLIFEd : ELIFE SCIENCES PUBLICATIONS LTDg 8q 8x 2050-084X
856	4	u https://doi.org/10.7554/eLife.47178y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1342885/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-390688
856	4 8	u https://doi.org/10.7554/eLife.47178
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:141219256

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