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  • Salim, RuthUniversity of Copenhagen,Copenhagen University Hospital (author)

Exploring new prognostic biomarkers in Mantle Cell Lymphoma : a comparison of the circSCORE and the MCL35 score

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2023
  • 10 s.

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  • LIBRIS-ID:oai:lup.lub.lu.se:7bea9be6-e245-4711-aa72-64eb7afe5bb9
  • https://lup.lub.lu.se/record/7bea9be6-e245-4711-aa72-64eb7afe5bb9URI
  • https://doi.org/10.1080/10428194.2023.2216819DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Mantle cell lymphoma (MCL) is a biologically and clinically heterogeneous disease, emphasizing the need for prognostic biomarkers. In this study we aimed at comparing the prognostic value of two RNA-based risk scores, circSCORE and MCL35, in 149 patients from the MCL2 (ISRCTN87866680) and MCL3 (NCT00514475) patient cohorts. Both risk scores provided significant stratification of high versus low risk for progression free survival (PFS) and overall survival (OS). The circSCORE retained significant prognostic value in adjusted multivariable Cox regressions for PFS, but not for OS. Furthermore, circSCORE added significant prognostic value to MIPI in the pooled cohort (MCL2 and MCL3) for PFS and OS, and for PFS in MCL3 alone, outperforming Ki67 and MCL35. We suggest a new, combined MIPI-circSCORE with improved prognostic value, and with potential for future clinical implementation, if validated in a larger, independent cohort.

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  • Husby, SimonUniversity of Copenhagen,Copenhagen University Hospital (author)
  • Winther Eskelund, ChristianCopenhagen University Hospital (author)
  • Scott, David W. (author)
  • Holte, HaraldOslo university hospital (author)
  • Kolstad, ArneInnlandet Hospital Trust (author)
  • Räty, RiikkaHelsinki University Central Hospital (author)
  • Ek, SaraLund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)immt-san (author)
  • Jerkeman, MatsLund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lymfom - Klinisk forskning,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Onkologi övergripande,Institutionen för kliniska vetenskaper, Lund,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lymphoma - Clinical Research,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Oncology corporate,Department of Clinical Sciences, Lund(Swepub:lu)onk-mje (author)
  • Geisler, ChristianCopenhagen University Hospital (author)
  • Sommer Kristensen, LasseAarhus University (author)
  • Dahl, MetteCopenhagen University Hospital,University of Copenhagen (author)
  • Grønbæk, KirstenUniversity of Copenhagen,Copenhagen University Hospital (author)
  • University of CopenhagenCopenhagen University Hospital (creator_code:org_t)

Related titles

  • In:Leukemia and Lymphoma64:8, s. 1414-14231042-8194

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