WFRF:(Zheng Ju Sheng)
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Health effects of high serum calcium levels : Updated phenome-wide Mendelian randomisation investigation and review of Mendelian randomisation studies
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- Yuan, Shuai (författare)
- Karolinska Institutet,Zhejiang Univ, Ctr Clin Big Data & Analyt, Dept Big Data Hlth Sci, Sch Publ Hlth,Affiliated Hosp 2,Sch Med, Hangzhou, Peoples R China.;Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden.;Westlake Univ, Sch Life Sci, Key Lab Growth Regulat & Translat Res Zhejiang Pr, Hangzhou, Peoples R China.
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- Yu, Lili (författare)
- Zhejiang Univ, Ctr Clin Big Data & Analyt, Dept Big Data Hlth Sci, Sch Publ Hlth,Affiliated Hosp 2,Sch Med, Hangzhou, Peoples R China.
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- Gou, Wanglong (författare)
- Westlake Univ, Sch Life Sci, Key Lab Growth Regulat & Translat Res Zhejiang Pr, Hangzhou, Peoples R China.
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- Karolinska Institutet Zhejiang Univ, Ctr Clin Big Data & Analyt, Dept Big Data Hlth Sci, Sch Publ Hlth,Affiliated Hosp 2,Sch Med, Hangzhou, Peoples R China;Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden.;Westlake Univ, Sch Life Sci, Key Lab Growth Regulat & Translat Res Zhejiang Pr, Hangzhou, Peoples R China. (creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
- Ingår i: EBioMedicine. - : Elsevier. - 2352-3964. ; 76
- Forskningsöversikt (refereegranskat)
Abstract
Ämnesord
Stäng
- BackgroundCalcium plays a role in a wide range of biological functions. Here we conducted a phenome-wide Mendelian randomisation (MR-PheWAS) analysis and a systematic review for MR studies to comprehensively investigate the health effects of serum calcium.MethodsOne-hundred and thirty genetic variants strongly associated with serum calcium levels were used as instrumental variables. A phenome-wide association analysis (PheWAS) was conducted to examine the associations of genetically predicted serum calcium with 1473 distinct phenotypes in the UK Biobank including 339,197 individuals. Observed associations in PheWAS were further tested for replication in two-sample MR replication analysis. A systematic review for MR studies on serum calcium was performed to synthesize the published evidence and compare with the current MR-PheWAS findings.FindingsHigher genetically predicted calcium levels were associated with decreased risk of 5 diseases in dermatologic and musculoskeletal systems and increased risk of 17 diseases in circulatory, digestive, endocrine, genitourinary and immune systems. Eight associations were replicated in two-sample MR analysis. These included decreased risk of osteoarthritis and increased risk of coronary artery disease, myocardial infarction, coronary atherosclerosis, hyperparathyroidism, disorder of parathyroid gland, gout, and calculus of kidney and ureter with increased serum calcium. Systematic review of 25 MR studies provided supporting evidence on five out of the eight disease outcomes, while the increased risk of gout, hyperparathyroidism and disorder of parathyroid gland were novel findings.InterpretationThis study found wide-ranged health effects of high serum calcium, which suggests that the benefits and adversities of strategies promoting calcium intake should be assessed
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Calcium
- Health
- Mendelian randomisation
- PheWAS
- Systematic review
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