Survivin expression is an independent prognostic factor in rectal cancer patients with and without preoperative radiotherapy

Knutsen Holmqvist, AnnicaÖstergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Onkologiska kliniken US (författare)

DOI does not work: 10.1016/S1570-0232(03)000207-1
Purpose: Survivin, as an inhibitor of apoptosis, is undetectable in normal tissues but expressed in tumors. Survivin expression in rectal cancer patients who have undergone preoperative radiotherapy (RT) alone has not been studied. We analyzed the relationships of survivin expression to RT, clinicopathologic variables, apoptosis, and p53 expression in rectal cancer patients who participated in a trial of preoperative RT. Methods and Materials: Survivin was immunohistochemically examined in 98 rectal tumors (74 had adjacent normal mucosa). Of 98 patients, 57 underwent surgery alone and 41 underwent RT before surgery. Results: Survivin positivity was related to worse survival, independent of Dukes' stage, local and distant recurrence, differentiation, gender, age, apoptosis, and p53 expression (p = 0.02). Survivin was not associated with survival in the patients without (p = 0.08) or with (p = 0.19) RT. After RT, survivin tended to be increased in adjacent normal mucosa (p = 0.057) but not in tumors (p = 0.71). Conclusion: Survivin was independently related to survival in rectal cancer patients who participated in a trial of preoperative RT, but not in either treatment group (surgery alone or surgery plus RT). Whether the effect of survivin on tumors is associated with RT and further related to patient survival needs to be investigated in a larger number of patients. (C) 2004 Elsevier Inc.

Adell, GunnarÖstergötlands Läns Landsting,Linköpings universitet,Institutionen för medicin och hälsa,Hälsouniversitetet,Onkologi,Onkologiska kliniken US(Swepub:liu)gunad10 (författare)
Sun, Xiao-FengÖstergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Onkologiska kliniken US(Swepub:liu)xiasu45 (författare)
Roman, MNationall Board Forensic Medicine (författare)
Linköpings universitetHälsouniversitetet (creator_code:org_t)

Ingår i:Journal of chromatography. B60:1, s. 149-1551570-02321873-376X
Ingår i:International Journal of Radiation Oncology, Biology, Physics60:1, s. 149-1550360-30161879-355X

Av författaren/redakt...: Knutsen Holmqvis ...; Adell, Gunnar; Sun, Xiao-Feng; Roman, M

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