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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006837naa a2200949 4500
001oai:DiVA.org:uu-105698
003SwePub
008090608s2008 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:0c62178f-6edc-4d4a-bc6a-c0917bb219a3
009oai:prod.swepub.kib.ki.se:118147428
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1056982 URI
024a https://doi.org/10.1196/annals.1447.0612 DOI
024a https://lup.lub.lu.se/record/13760162 URI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1181474282 URI
040 a (SwePub)uud (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Sanjeevi, Carani B.u Karolinska Institutet4 aut
2451 0a The risk conferred by HLA-DR and DQ for type 1 diabetes in 0-35-year age group are different in different regions of Sweden
264 1b Wiley,c 2008
338 a print2 rdacarrier
520 a HLA DR4-DQ8 and DR3-DQ2 haplotypes account for 89% of newly diagnosed cases of type 1 diabetes (T1D) in Sweden. The presence of a single copy of DQ6 confers protection. The aim of the present study is to evaluate whether the risk conferred by high risk HLA DR and DQ to T1D is similar in all regions of Sweden and see whether there are any significant regional differences. The subjects comprised 799 consecutively diagnosed T1D patients and 585 age-, sex-, and geography-matched healthy controls in the age group 0-35 years. HLA typing for high-risk haplotypes was previously performed using PCR-SSOP and RFLP. The results showed that HLA DR3-DR4 gave an odds ratio of 8.14 for the whole of Sweden. However, when the study group was divided into six geographical regions, subjects from Stockholm had the highest OR, followed by those from Lund, Linköping, Gothenburg, Umeå, and Uppsala. Absolute protection was conferred by the presence of DQ6 in subjects from the Linköping region, but varied in the other regions. The frequency of DR3 and DQ2, DR4 and DQ8, DR15, and DQ6 in patients showed high linkage for each region, but were different between regions. In conclusion: The risk conferred by high-risk HLA varies in different regions for a homogenous population in Sweden. The results highlight the important role played by the various environmental factors in the precipitation of T1D.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a type 1 diabetes
653 a HLA-DR and DQ
653 a environmental factors
653 a genetic susceptibility
653 a MEDICINE
653 a MEDICIN
653 a HLA-DR and DQ
653 a type 1 diabetes
653 a environmental factors
653 a susceptibility
653 a genetic
700a Sedimbi, Saikiran K.u Karolinska Institutet4 aut
700a Landin-Olsson, Monau Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-mla
700a Kockum, Ingridu Karolinska Institutet4 aut
700a Lernmark, Åkeu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 aut0 (Swepub:lu)endo-ale
700a Aili, M.u Dept. of Pediatrics, Halmstad, Sweden4 aut
700a Bååth, L.E.u Dept. of Pediatrics, Östersund, Sweden,Dept. of Pediatrics, Mölndal, Sweden4 aut
700a Carlsson, E.u Dept. of Pediatrics, Kalmar, Sweden4 aut
700a Edenwall, H.u Dept. of Pediatrics, Karlskrona, Sweden,Dept. of Pediatrics, Umeå, Sweden4 aut
700a Forsander, G.u Dept. of Pediatrics, Falun, Sweden4 aut
700a Granström, B.W.u Dept. of Pediatrics, Gällivare, Sweden4 aut
700a Gustavsson, I.u Dept. of Pediatrics, Skellefteå, Sweden4 aut
700a Hanås, R.u Dept. of Pediatrics, Uddevalla, Sweden4 aut
700a Hellenberg, L.u Dept. of Pediatrics, Nyköping, Sweden4 aut
700a Hellgren, H.u Dept. of Pediatrics, Linköping, Sweden,Dept. of Pediatrics, Hudiksvall, Sweden4 aut
700a Holmberg, E.u Dept. of Pediatrics, Umeå, Sweden4 aut
700a Hörnell, H.u Dept. of Pediatrics, Hudiksvall, Sweden4 aut
700a Ivarsson, Sten-A.u Dept. of Pediatrics, Malmö, Sweden4 aut
700a Johansson, C.u Dept. of Pediatrics, Jönköping, Sweden4 aut
700a Jonsell, G.u Dept. of Pediatrics, Karlstad, Sweden4 aut
700a Kockum, K.u Dept. of Pediatrics, Ystad, Sweden,Dept. of Pediatrics, Eskilstuna, Sweden,Dept. of Pediatrics, Danderyd, Sweden4 aut
700a Lindblad, B.u Dept. of Pediatrics, Mölndal, Sweden4 aut
700a Lindh, A.u Dept. of Pediatrics, Borås, Sweden4 aut
700a Ludvigsson, J.u Dept. of Pediatrics, Linköping, Sweden4 aut
700a Myrdal, U.u Dept. of Pediatrics, Västerås, Sweden4 aut
700a Neiderud, J.u Dept. of Pediatrics, Helsingborg, Sweden4 aut
700a Segnestam, K.u Dept. of Pediatrics, Eskilstuna, Sweden4 aut
700a Sjöblad, S.u Dept. of Pediatrics, Lund, Sweden4 aut
700a Skogsberg, L.u Dept. of Pediatrics, Boden, Sweden4 aut
700a Strömberg, L.u Dept. of Pediatrics, Norrköping, Sweden4 aut
700a Ståhle, U.u Dept. of Pediatrics, Ängelholm, Sweden4 aut
700a Thalme, B.u Dept. of Pediatrics, Huddinge, Sweden4 aut
700a Tullus, K.u Dept. of Pediatrics, Danderyd, Sweden4 aut
700a Tuvemo, Torstenu Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Gustafsson4 aut0 (Swepub:uu)torstuve
700a Wallensteen, M.u Dept. of Pediatrics, Stockholm, Sweden4 aut
700a Westphal, O.u Dept. of Pediatrics, Göteborg, Sweden4 aut
700a Dahlquist, G.u Dept. of Pediatrics, Umeå, Sweden4 aut
700a Åman, J.u Dept. of Pediatrics, Örebro, Sweden4 aut
700a Schatz, DA4 aut
710a Karolinska Institutetb Medicin, Lund4 org
773t Annals of the New York Academy of Sciencesd : Wileyg 1150, s. 106-11q 1150<106-11x 0077-8923x 1749-6632z 9781573317337
856u http://dx.doi.org/10.1196/annals.1447.061y FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-105698
8564 8u https://doi.org/10.1196/annals.1447.061
8564 8u https://lup.lub.lu.se/record/1376016
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:118147428

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