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Crystal structures of OrfX2 and P47 from a Botulinum neurotoxin OrfX-type gene cluster
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- Gustafsson, Robert (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Berntsson, Ronnie P. A. (author)
- Umeå universitet,Stockholms universitet,Institutionen för biokemi och biofysik,Umeå University, Sweden,Institutionen för medicinsk kemi och biofysik
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- Martínez-Carranza, Markel (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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- Johnson, Eric A. (author)
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- (creator_code:org_t)
- 2017-11-05
- 2017
- English.
- In: FEBS Letters. - : Wiley. - 0014-5793 .- 1873-3468. ; 591:22, s. 3781-3792
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Botulinum neurotoxins are highly toxic substances and are all encoded together with one of two alternative gene clusters, the HA or the OrfX gene cluster. Very little is known about the function and structure of the proteins encoded in the OrfX gene cluster, which in addition to the toxin contains five proteins (OrfX1, OrfX2, OrfX3, P47, and NTNH). We here present the structures of OrfX2 and P47, solved to 2.1 and 1.8 Å, respectively. We show that they belong to the TULIP protein superfamily, which are often involved in lipid binding. OrfX1 and OrfX2 were both found to bind phosphatidylinositol lipids.
Subject headings
- NATURVETENSKAP -- Biologi -- Strukturbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Structural Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- botulinum neurotoxin
- Crystallography
- gene cluster
- TULIP
- X-ray
- Biochemistry
- biokemi
Publication and Content Type
- ref (subject category)
- art (subject category)
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