Sökning: WFRF:(Blin S) > Cerebrospinal fluid...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 10496naa a2201033 4500 | |
001 | oai:gup.ub.gu.se/280887 | |
003 | SwePub | |
008 | 240910s2019 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:oru-74036 | |
009 | oai:prod.swepub.kib.ki.se:140850110 | |
024 | 7 | a https://gup.ub.gu.se/publication/2808872 URI |
024 | 7 | a https://doi.org/10.1016/j.jalz.2019.01.0042 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-740362 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1408501102 URI |
040 | a (SwePub)gud (SwePub)orud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Bos, I.u Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands4 aut |
245 | 1 0 | a Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum |
264 | c 2019-03-07 | |
264 | 1 | b Wiley,c 2019 |
520 | a Introduction: We investigated relations between amyloid-beta (A beta) status, apolipoprotein E (APOE) e4, and cognition, with cerebrospinal fluid markers of neurogranin (Ng), neurofilament light (NFL), YKL-40, and total tau (T-tau). Methods: We included 770 individuals with normal cognition, mild cognitive impairment, and Alzheimer's disease (AD)-type dementia from the EMIF-AD Multimodal Biomarker Discovery study. We tested the association of Ng, NFL, YKL-40, and T-tau with A beta status (Ab beta- vs. A beta+), clinical diagnosis APOE epsilon 4 carriership, baseline cognition, and change in cognition. Results: Ng and T-tau distinguished between A beta+ from A beta- individuals in each clinical group, whereas NFL and YKL-40 were associated with A beta+ in nondemented individuals only. APOE epsilon 4 carriership did not influence NFL, Ng, and YKL-40 in A beta+ individuals. NFL was the best predictor of cognitive decline in A beta+ individuals across the cognitive spectrum. Discussion: Axonal degeneration, synaptic dysfunction, astroglial activation, and altered tau metabolism are involved already in preclinical AD. NFL may be a useful prognostic marker. (C) 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Geriatrik0 (SwePub)302222 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Geriatrics0 (SwePub)302222 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng |
653 | a Alzheimer's disease | |
653 | a Amyloid-beta | |
653 | a Neurofilament light | |
653 | a Neurogranin | |
653 | a YKL-40 | |
653 | a Cognition | |
653 | a Cerebrospinal fluid | |
653 | a APOE | |
653 | a mild cognitive impairment | |
653 | a neurofilament light | |
653 | a neurogranin | |
653 | a protein | |
653 | a pathology | |
653 | a ykl-40 | |
653 | a tau | |
653 | a degeneration | |
653 | a association | |
653 | a guidelines | |
653 | a APOE | |
700 | 1 | a Vos, S.u Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands4 aut |
700 | 1 | a Verhey, F.u Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands4 aut |
700 | 1 | a Scheltens, P.u Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands4 aut |
700 | 1 | a Teunissen, C.u Neurochemistry Lab and Biobank, Department of Clinical Chemistry, VU University Medical Center, Amsterdam Neuroscience, Amsterdam, the Netherlands4 aut |
700 | 1 | a Engelborghs, S.u Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium; Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium4 aut |
700 | 1 | a Sleegers, K.u Institute Born-Bunge, University of Antwerp, Antwerp, Belgium; Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium4 aut |
700 | 1 | a Frisoni, G.u University of Geneva, Geneva, Switzerland; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy4 aut |
700 | 1 | a Blin, O.u Mediterranean Institute of Cognitive Neuroscience, Aix Marseille University, Marseille, France4 aut |
700 | 1 | a Richardson, J. C.u Neurosciences Therapeutic Area, GlaxoSmithKline R&D, Stevenage, UK4 aut |
700 | 1 | a Bordet, R.u University of Lille, Inserm, CHU Lille, Lille, France4 aut |
700 | 1 | a Tsolaki, M.u 1st Department of Neurology, AHEPA University Hospital, Makedonia, Thessaloniki, Greece4 aut |
700 | 1 | a Popp, J.u Geriatric Psychiatry, Department of Mental Health and Psychiatry, Geneva University Hospitals, Geneva, Switzerland; Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland4 aut |
700 | 1 | a Peyratout, G.u Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland4 aut |
700 | 1 | a Martinez-Lage, P.u Department of Neurology, Center for Research and Advanced Therapies, CITA-Alzheimer Foundation, San Sebastian, Spain4 aut |
700 | 1 | a Tainta, M.u Department of Neurology, Center for Research and Advanced Therapies, CITA-Alzheimer Foundation, San Sebastian, Spain4 aut |
700 | 1 | a Lleo, A.u Hospital de la Santa Creu i Sant Pau, Barcelona, Spain4 aut |
700 | 1 | a Johannsen, P.u Danish Dementia Research Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark4 aut |
700 | 1 | a Freund-Levi, Yvonne,d 1956-u Department of Neurobiology, Caring Sciences and Society (NVS), Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden; Department of Psychiatry Norrtälje Hospital Tiohundra, Norrtäije, Sweden4 aut0 (Swepub:oru)yfi |
700 | 1 | a Frolich, L.u Department of Geriatric Psychiatry, Zentralinstitut für Seelische Gesundheit, University of Heidelberg, Mannheim, Germany4 aut |
700 | 1 | a Vandenberghe, R.u University Hospital Leuven, Leuven, Belgium4 aut |
700 | 1 | a Westwood, S.u University of Oxford, Oxford, United Kingdom4 aut |
700 | 1 | a Dobricic, V.u Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany4 aut |
700 | 1 | a Barkhof, F.u Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands; Institutes of Neurology and Healthcare Engineering, University College London, London, UK4 aut |
700 | 1 | a Legido-Quigley, C.u Steno Diabetes Center, Copenhagen, Denmark; King's College London, London, UK4 aut |
700 | 1 | a Bertram, L.u Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany; School of Public Health, Imperial College London, London, UK; Department of Psychology, University of Oslo, Oslo, Norway4 aut |
700 | 1 | a Lovestone, S.u University of Oxford, Oxford, United Kingdom4 aut |
700 | 1 | a Streffer, J.u Reference Center for Biological Markers of Dementia (BIODEM), Institute Born-Bunge, University of Antwerp, Antwerp, Belgium; Early Clinial Neurology, UCB Biopharma SPRL, Braine-l'Alleud, Belgium4 aut |
700 | 1 | a Andreasson, Ulf,d 1968u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Clinical Neurochemistry Lab, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Psychiatry and Neurochemistry, University of Gothenburg, Institute of Neuroscience and Physiology, Mölndal, Sweden4 aut0 (Swepub:gu)xaulfz |
700 | 1 | a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Clinical Neurochemistry Lab, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Psychiatry and Neurochemistry, University of Gothenburg, Institute of Neuroscience and Physiology, Mölndal, Sweden4 aut0 (Swepub:gu)xbleka |
700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Clinical Neurochemistry Lab, Institute of Neuroscience and Physiology, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Psychiatry and Neurochemistry, University of Gothenburg, Institute of Neuroscience and Physiology, Mölndal, Sweden; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK; UK Dementia Research Institute, London, UK4 aut0 (Swepub:gu)xzethe |
700 | 1 | a Visser, P. J.u Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands; Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands4 aut |
710 | 2 | a Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlandsb Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands4 org |
773 | 0 | t Alzheimers & Dementiad : Wileyg 15:5, s. 644-654q 15:5<644-654x 1552-5260x 1552-5279 |
856 | 4 | u https://discovery.ucl.ac.uk/10070879/3/Barkhof%20Bos%20-%20Manuscript_EMIF%20CSF%201000_FINAL%20-%20Alz%20%26%20Dem%20accepted%20version.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/280887 |
856 | 4 8 | u https://doi.org/10.1016/j.jalz.2019.01.004 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-74036 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:140850110 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.