WFRF:(Butler KM)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02570naa a2200373 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:230956813 | |
| 003 | SwePub | |
| 008 | 240811s2019 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:2309568132 URI |
| 024 | 7 | a https://doi.org/10.1155/2019/65942122 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Ochaya, S4 aut |
| 245 | 1 0 | a Characterization of Evolutionarily Conserved Trypanosoma cruzi NatC and NatA-N-Terminal Acetyltransferase Complexes |
| 264 | 1 | b Hindawi Limited,c 2019 |
| 520 | a Protein N-terminal acetylation is a co- and posttranslational modification, conserved among eukaryotes. It determines the functional fate of many proteins including their stability, complex formation, and subcellular localization. N-terminal acetyltransferases (NATs) transfer an acetyl group to the N-termini of proteins, and the major NATs in yeast and humans are NatA, NatB, and NatC. In this study, we characterized the Trypanosoma cruzi (T. cruzi) NatC and NatA protein complexes, each consisting of one catalytic subunit and predicted auxiliary subunits. The proteins were found to be expressed in the three main life cycle stages of the parasite, formed stable complexes in vivo, and partially cosedimented with the ribosome in agreement with a cotranslational function. An in vitro acetylation assay clearly demonstrated that the acetylated substrates of the NatC catalytic subunit from T. cruzi were similar to those of yeast and human NatC, suggesting evolutionary conservation of function. An RNAi knockdown of the Trypanosoma brucei (T. brucei) NatC catalytic subunit indicated that reduced NatC-mediated N-terminal acetylation of target proteins reduces parasite growth. | |
| 700 | 1 | a Franzén, Ou Karolinska Institutet4 aut |
| 700 | 1 | a Buhwa, DA4 aut |
| 700 | 1 | a Foyn, H4 aut |
| 700 | 1 | a Butler, CE4 aut |
| 700 | 1 | a Stove, SI4 aut |
| 700 | 1 | a Tyler, KM4 aut |
| 700 | 1 | a Arnesen, T4 aut |
| 700 | 1 | a Matovu, E4 aut |
| 700 | 1 | a Åslund, L4 aut |
| 700 | 1 | a Andersson, Bu Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Journal of parasitology researchd : Hindawi Limitedg 2019, s. 6594212-q 2019<6594212-x 2090-0023x 2090-0031 |
| 856 | 4 | u https://doi.org/10.1155/2019/6594212 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:230956813 |
| 856 | 4 8 | u https://doi.org/10.1155/2019/6594212 |
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- Ochaya, S
- Franzén, O
- Buhwa, DA
- Foyn, H
- Butler, CE
- Stove, SI
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- Tyler, KM
- Arnesen, T
- Matovu, E
- Åslund, L
- Andersson, B
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