The genomic landscape of core-binding factor acute myeloid leukemias

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Fältnamn	Indikatorer	Metadata
000		04578naa a2200889 4500
001		oai:lup.lub.lu.se:20d7ddf7-6757-4e92-aafa-dd04717edde5
003		SwePub
008		161123s2016 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/20d7ddf7-6757-4e92-aafa-dd04717edde52 URI
024	7	a https://doi.org/10.1038/ng.37092 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Faber, Zachary J4 aut
245	1 0	a The genomic landscape of core-binding factor acute myeloid leukemias
264		c 2016-10-31
264	1	b Springer Science and Business Media LLC,c 2016
300		a 6 s.
520		a Acute myeloid leukemia (AML) comprises a heterogeneous group of leukemias frequently defined by recurrent cytogenetic abnormalities, including rearrangements involving the core-binding factor (CBF) transcriptional complex. To better understand the genomic landscape of CBF-AMLs, we analyzed both pediatric (n = 87) and adult (n = 78) samples, including cases with RUNX1-RUNX1T1 (n = 85) or CBFB-MYH11 (n = 80) rearrangements, by whole-genome or whole-exome sequencing. In addition to known mutations in the Ras pathway, we identified recurrent stabilizing mutations in CCND2, suggesting a previously unappreciated cooperating pathway in CBF-AML. Outside of signaling alterations, RUNX1-RUNX1T1 and CBFB-MYH11 AMLs demonstrated remarkably different spectra of cooperating mutations, as RUNX1-RUNX1T1 cases harbored recurrent mutations in DHX15 and ZBTB7A, as well as an enrichment of mutations in epigenetic regulators, including ASXL2 and the cohesin complex. This detailed analysis provides insights into the pathogenesis and development of CBF-AML, while highlighting dramatic differences in the landscapes of cooperating mutations for these related AML subtypes.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng
700	1	a Chen, Xiang4 aut
700	1	a Gedman, Amanda Larson4 aut
700	1	a Boggs, Kristy4 aut
700	1	a Cheng, Jinjun4 aut
700	1	a Ma, Jing4 aut
700	1	a Radtke, Ina4 aut
700	1	a Chao, Jyh-Rong4 aut
700	1	a Walsh, Michael P4 aut
700	1	a Song, Guangchun4 aut
700	1	a Andersson, Anna Ku Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,St Jude Children´s Research Hospital, Memphis4 aut0 (Swepub:lu)kgen-aan
700	1	a Dang, Jinjun4 aut
700	1	a Dong, Li4 aut
700	1	a Liu, Yu4 aut
700	1	a Huether, Robert4 aut
700	1	a Cai, Zhongling4 aut
700	1	a Mulder, Heather4 aut
700	1	a Wu, Gang4 aut
700	1	a Edmonson, Michael4 aut
700	1	a Rusch, Michael4 aut
700	1	a Qu, Chunxu4 aut
700	1	a Li, Yongjin4 aut
700	1	a Vadodaria, Bhavin4 aut
700	1	a Wang, Jianmin4 aut
700	1	a Hedlund, Erin4 aut
700	1	a Cao, Xueyuan4 aut
700	1	a Yergeau, Donald4 aut
700	1	a Nakitandwe, Joy4 aut
700	1	a Pounds, Stanley B4 aut
700	1	a Shurtleff, Sheila4 aut
700	1	a Fulton, Robert S4 aut
700	1	a Fulton, Lucinda L4 aut
700	1	a Easton, John4 aut
700	1	a Parganas, Evan4 aut
700	1	a Pui, Ching-Hon4 aut
700	1	a Rubnitz, Jeffrey E4 aut
700	1	a Ding, Li4 aut
700	1	a Mardis, Elaine R4 aut
700	1	a Wilson, Richard K4 aut
700	1	a Gruber, Tanja A4 aut
700	1	a Mullighan, Charles G4 aut
700	1	a Schlenk, Richard F4 aut
700	1	a Paschka, Peter4 aut
700	1	a Döhner, Konstanze4 aut
700	1	a Döhner, Hartmut4 aut
700	1	a Bullinger, Lars4 aut
700	1	a Zhang, Jinghui4 aut
700	1	a Klco, Jeffery M4 aut
700	1	a Downing, James R4 aut
710	2	a Avdelningen för klinisk genetikb Institutionen för laboratoriemedicin4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 48, s. 1551-1556q 48<1551-1556x 1546-1718x 1061-4036
856	4	u http://dx.doi.org/10.1038/ng.3709y FULLTEXT
856	4	u https://europepmc.org/articles/pmc5508996?pdf=render
856	4 8	u https://lup.lub.lu.se/record/20d7ddf7-6757-4e92-aafa-dd04717edde5
856	4 8	u https://doi.org/10.1038/ng.3709

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Av författaren/redakt...: Faber, Zachary J; Chen, Xiang; Gedman, Amanda L ...; Boggs, Kristy; Cheng, Jinjun; Ma, Jing; visa fler...; Radtke, Ina; Chao, Jyh-Rong; Walsh, Michael P; Song, Guangchun; Andersson, Anna ...; Dang, Jinjun; Dong, Li; Liu, Yu; Huether, Robert; Cai, Zhongling; Mulder, Heather; Wu, Gang; Edmonson, Michae ...; Rusch, Michael; Qu, Chunxu; Li, Yongjin; Vadodaria, Bhavi ...; Wang, Jianmin; Hedlund, Erin; Cao, Xueyuan; Yergeau, Donald; Nakitandwe, Joy; Pounds, Stanley ...; Shurtleff, Sheil ...; Fulton, Robert S; Fulton, Lucinda ...; Easton, John; Parganas, Evan; Pui, Ching-Hon; Rubnitz, Jeffrey ...; Ding, Li; Mardis, Elaine R; Wilson, Richard ...; Gruber, Tanja A; Mullighan, Charl ...; Schlenk, Richard ...; Paschka, Peter; Döhner, Konstanz ...; Döhner, Hartmut; Bullinger, Lars; Zhang, Jinghui; Klco, Jeffery M; Downing, James R; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Hematologi

Artiklar i publikationen: Nature Genetics

Av lärosätet: Lunds universitet

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