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Genetic basis of PD...
Genetic basis of PD-L1 overexpression in diffuse large B-cell lymphomas
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- Georgiou, Konstantinos (author)
- Karolinska Inst, Karolinska Univ Hosp, Dept Lab Med, Clin Immunol, Huddinge, Sweden.
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- Chen, Longyun (author)
- Karolinska Inst, Karolinska Univ Hosp, Dept Lab Med, Clin Immunol, Huddinge, Sweden.;BGI Shenzhen, Shenzhen, Peoples R China.
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- Berglund, Mattias (author)
- Karolinska Institutet
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- Ren, Weicheng (author)
- Karolinska Institutet
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- de Miranda, Noel F. C. C. (author)
- Leiden Univ, Dept Pathol, Med Ctr, Leiden, Netherlands.
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- Lisboa, Susana (author)
- Univ Porto, Portuguese Oncol Inst, Dept Genet, Rua Campo Alegre 823, P-4100 Oporto, Portugal.;Univ Porto, Abel Salazar Biomed Sci Inst, Rua Campo Alegre 823, P-4100 Oporto, Portugal.
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- Fangazio, Marco (author)
- Columbia Univ, Inst Canc Genet, New York, NY USA.
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- Zhu, Shida (author)
- BGI Shenzhen, Shenzhen, Peoples R China.
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- Hou, Yong (author)
- BGI Shenzhen, Shenzhen, Peoples R China.
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- Wu, Kui (author)
- BGI Shenzhen, Shenzhen, Peoples R China.
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- Fang, Wenfeng (author)
- Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China.;Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China.
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- Wang, Xianhuo (author)
- Tianjin Med Univ Canc Inst & Hosp, Dept Lymphoma, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China.
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- Meng, Bin (author)
- Tianjin Med Univ Canc Inst & Hosp, Dept Lymphoma, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China.
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- Zhang, Li (author)
- Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China.;Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China.
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- Zeng, Yixin (author)
- Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China.;Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China.
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- Bhagat, Govind (author)
- Columbia Univ, Dept Pathol & Cell Biol, New York, NY USA.
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- Nordenskjold, Magnus (author)
- Karolinska Institutet
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- Sundström, Christer (author)
- Uppsala universitet,Klinisk och experimentell patologi,Rose-Marie Amini
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- Enblad, Gunilla (author)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Dalla-Favera, Riccardo (author)
- Columbia Univ, Inst Canc Genet, New York, NY USA.
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- Zhang, Huilai (author)
- Tianjin Med Univ Canc Inst & Hosp, Dept Lymphoma, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China.
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- Teixeira, Manuel R. (author)
- Univ Porto, Portuguese Oncol Inst, Dept Genet, Rua Campo Alegre 823, P-4100 Oporto, Portugal.;Univ Porto, Abel Salazar Biomed Sci Inst, Rua Campo Alegre 823, P-4100 Oporto, Portugal.
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- Pasqualucci, Laura (author)
- Columbia Univ, Inst Canc Genet, New York, NY USA.
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- Peng, Roujun (author)
- Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China.;Sun Yat Sen Univ, Ctr Canc, Dept Med Oncol, Guangzhou 510275, Guangdong, Peoples R China.
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- Pan-Hammarstrom, Qiang (author)
- Karolinska Institutet
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Karolinska Inst, Karolinska Univ Hosp, Dept Lab Med, Clin Immunol, Huddinge, Sweden Karolinska Inst, Karolinska Univ Hosp, Dept Lab Med, Clin Immunol, Huddinge, Sweden.;BGI Shenzhen, Shenzhen, Peoples R China. (creator_code:org_t)
- American Society of Hematology, 2016
- 2016
- English.
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In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 127:24, s. 3026-3034
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Diffuse large B-cell lymphoma (DLBCL) is one of the most common and aggressive types of B-cell lymphoma. Deregulation of proto-oncogene expression after a translocation, most notably to the immunoglobulin heavy-chain locus (IGH), is one of the hallmarks of DLBCL. Using whole-genome sequencing analysis, we have identified the PD-L1/PD-L2 locus as a recurrent translocation partner for IGH in DLBCL. PIM1 and TP63 were also identified as novel translocation partners for PD-L1/PD-L2. Fluorescence in situ hybridization was furthermore used to rapidly screen an expanded DLBCL cohort. Collectively, a subset of samples was found to be affected by gains (12%), amplifications (3%), and translocations (4%) of the PD-L1/PD-L2 locus. RNA sequencing data coupled with immunohistochemistry revealed that these cytogenetic alterations correlated with increased expression of PD-L1 but not of PD-L2. Moreover, cytogenetic alterations affecting the PD-L1/PD-L2 locus were more frequently observed in the non-germinal center B cell-like (non-GCB) subtype of DLBCL. These findings demonstrate the genetic basis of PD-L1 overexpression in DLBCL and suggest that treatments targeting the PD-1-PD-L1/PD-L2 axis might benefit DLBCL patients, especially those belonging to the more aggressive non-GCB subtype.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- Patologi
- Pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Blood
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- By the author/editor
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Georgiou, Konsta ...
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Chen, Longyun
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Berglund, Mattia ...
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Ren, Weicheng
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de Miranda, Noel ...
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Lisboa, Susana
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Fangazio, Marco
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Zhu, Shida
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Hou, Yong
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Wu, Kui
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Fang, Wenfeng
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Wang, Xianhuo
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Meng, Bin
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Zhang, Li
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Zeng, Yixin
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Bhagat, Govind
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Nordenskjold, Ma ...
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Sundström, Chris ...
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Enblad, Gunilla
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Dalla-Favera, Ri ...
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Zhang, Huilai
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Teixeira, Manuel ...
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Pasqualucci, Lau ...
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Peng, Roujun
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Pan-Hammarstrom, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
- Articles in the publication
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Blood
- By the university
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Uppsala University
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Karolinska Institutet