Search: WFRF:(Eisler T) >
Human Synovial Lubr...
-
Jin, ChunshengGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
(author)
Human Synovial Lubricin Expresses Sialyl Lewis x Determinant and Has L-selectin Ligand Activity
- Article/chapterEnglish2012
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:gup.ub.gu.se/166873
-
https://gup.ub.gu.se/publication/166873URI
-
https://doi.org/10.1074/jbc.M112.363119DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:125519645URI
Supplementary language notes
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Lubricin (or proteoglycan 4 (PRG4)) is an abundant mucin-like glycoprotein in synovial fluid (SF) and a major component responsible for joint lubrication. In this study, it was shown that O-linked core 2 oligosaccharides (Gal beta 1-3(GlcNAc beta 1-6)GalNAc alpha 1-Thr/Ser) on lubricin isolated from rheumatoid arthritis SF contained both sulfate and fucose residues, and SF lubricin was capable of binding to recombinant L-selectin in a glycosylation-dependent manner. Using resting human polymorphonuclear granulocytes (PMN) from peripheral blood, confocal microscopy showed that lubricin coated circulating PMN and that it partly co-localized with L-selectin expressed by these cells. In agreement with this, activation-induced shedding of L-selectin also mediated decreased lubricin binding to PMN. It was also found that PMN recruited to inflamed synovial area and fluid in rheumatoid arthritis patients kept a coat of lubricin. These observations suggest that lubricin is able to bind to PMN via an L-selectin-dependent and -independent manner and may play a role in PMN-mediated inflammation.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Ekwall, Anna-Karin HGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xhannp
(author)
-
Bylund, Johan,1975Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xbyljo
(author)
-
Björkman, Lena,1965Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xblenv
(author)
-
Estrella, R. P.
(author)
-
Whitelock, J. M.
(author)
-
Eisler, T.
(author)
-
Bokarewa, Maria,1963Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xbokma
(author)
-
Karlsson, Niclas G.,1966Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology(Swepub:gu)xkanic
(author)
-
Göteborgs universitetInstitutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi
(creator_code:org_t)
Related titles
-
In:Journal of Biological Chemistry287:43, s. 35922-359330021-92581083-351X
Internet link
Find in a library
To the university's database
- By the author/editor
-
Jin, Chunsheng
-
Ekwall, Anna-Kar ...
-
Bylund, Johan, 1 ...
-
Björkman, Lena, ...
-
Estrella, R. P.
-
Whitelock, J. M.
-
show more...
-
Eisler, T.
-
Bokarewa, Maria, ...
-
Karlsson, Niclas ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Medical Biotechn ...
- Articles in the publication
-
Journal of Biolo ...
- By the university
-
University of Gothenburg
-
Karolinska Institutet