Association of Factor V Leiden With Subsequent Atherothrombotic Events A GENIUS-CHD Study of Individual Participant Data

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Fältnamn	Indikatorer	Metadata
000		17673naa a2201357 4500
001		oai:DiVA.org:uu-421550
003		SwePub
008		201015s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4215502 URI
024	7	a https://doi.org/10.1161/CIRCULATIONAHA.119.0455262 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Mahmoodi, Bakhtawar K.u St Antonius Hosp, Dept Cardiol, Nieuwegein, Netherlands.;Univ Groningen, Div Hemostasis & Thrombosis, Dept Hematol, UMC Groningen, Groningen, Netherlands.4 aut
245	1 0	a Association of Factor V Leiden With Subsequent Atherothrombotic Events A GENIUS-CHD Study of Individual Participant Data
264	1	b Ovid Technologies (Wolters Kluwer Health),c 2020
338		a print2 rdacarrier
520		a Background: Studies examining the role of factor V Leiden among patients at higher risk of atherothrombotic events, such as those with established coronary heart disease (CHD), are lacking. Given that coagulation is involved in the thrombus formation stage on atherosclerotic plaque rupture, we hypothesized that factor V Leiden may be a stronger risk factor for atherothrombotic events in patients with established CHD.Methods: We performed an individual-level meta-analysis including 25 prospective studies (18 cohorts, 3 case-cohorts, 4 randomized trials) from the GENIUS-CHD (Genetics of Subsequent Coronary Heart Disease) consortium involving patients with established CHD at baseline. Participating studies genotyped factor V Leiden status and shared risk estimates for the outcomes of interest using a centrally developed statistical code with harmonized definitions across studies. Cox proportional hazards regression models were used to obtain age- and sex-adjusted estimates. The obtained estimates were pooled using fixed-effect meta-analysis. The primary outcome was composite of myocardial infarction and CHD death. Secondary outcomes included any stroke, ischemic stroke, coronary revascularization, cardiovascular mortality, and all-cause mortality.Results: The studies included 69 681 individuals of whom 3190 (4.6%) were either heterozygous or homozygous (n=47) carriers of factor V Leiden. Median follow-up per study ranged from 1.0 to 10.6 years. A total of 20 studies with 61 147 participants and 6849 events contributed to analyses of the primary outcome. Factor V Leiden was not associated with the combined outcome of myocardial infarction and CHD death (hazard ratio, 1.03 [95% CI, 0.92-1.16];I-2=28%;P-heterogeneity=0.12). Subgroup analysis according to baseline characteristics or strata of traditional cardiovascular risk factors did not show relevant differences. Similarly, risk estimates for the secondary outcomes including stroke, coronary revascularization, cardiovascular mortality, and all-cause mortality were also close to identity.Conclusions: Factor V Leiden was not associated with increased risk of subsequent atherothrombotic events and mortality in high-risk participants with established and treated CHD. Routine assessment of factor V Leiden status is unlikely to improve atherothrombotic events risk stratification in this population.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653		a coronary artery disease
653		a genetic association studies
653		a thrombosis
653		a prognosis
653		a single nucleotide polymorphism
653		a myocardial infarction
653		a secondary prevention
700	1	a Tragante, Viniciusu Univ Utrecht, UMC Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands.4 aut
700	1	a Kleber, Marcus E.u Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Heidelberg, Germany.4 aut
700	1	a Holmes, Michael V.u Univ Oxford, Clin Trial Serv Unit, Oxford, England.;Univ Oxford, Epidemiol Studies Unit, Nuffield Dept Populat Hlth, Oxford, England.;Univ Oxford, Med Res Council, Populat Hlth Res Unit, Oxford, England.;Oxford Univ Hosp, Natl Inst Hlth Res, Oxford Biomed Res Ctr, Oxford, England.4 aut
700	1	a Schmidt, Amand F.u UCL, Inst Cardiovasc Sci, 222 Euston Rd, London NW1 2DA, England.;Univ Utrecht, UMC Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands.;UCL, UCL BHF Res Accelerator, Fac Populat Hlth Sci, London, England.4 aut
700	1	a McCubrey, Raymond O.u Intermt Med Ctr, Intermt Heart Inst, Salt Lake City, UT USA.4 aut
700	1	a Howe, Laurence J.u UCL, Inst Cardiovasc Sci, 222 Euston Rd, London NW1 2DA, England.;UCL, UCL BHF Res Accelerator, Fac Populat Hlth Sci, London, England.4 aut
700	1	a Direk, Kenanu UCL, Inst Cardiovasc Sci, 222 Euston Rd, London NW1 2DA, England.;UCL, UCL BHF Res Accelerator, Fac Populat Hlth Sci, London, England.4 aut
700	1	a Allayee, Hoomanu Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90007 USA.;Univ Southern Calif, Keck Sch Med, Dept Biochem & Mol Med, Los Angeles, CA 90007 USA.4 aut
700	1	a Baranova, Ekaterina V.u Univ Utrecht, UMC Utrecht, Div Pharmacoepidemiol & Clin Pharm, Utrecht, Netherlands.4 aut
700	1	a Braund, Peter S.u Univ Leicester, Glenfield Hosp, Dept Cardiovasc Sci, BHF Cardiovasc Res Ctr, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England.4 aut
700	1	a Delgado, Graciela E.u Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Heidelberg, Germany.4 aut
700	1	a Eriksson, Niclas,d 1978-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)nieri103
700	1	a Gijsberts, Crystel M.u Univ Utrecht, UMC Utrecht, Lab Expt Cardiol, Utrecht, Netherlands.4 aut
700	1	a Gong, Yanu Univ Florida, Dept Pharmacotherapy & Translat Res, Gainesville, FL USA.;Univ Florida, Ctr Pharmacogen, Gainesville, FL USA.4 aut
700	1	a Hartiala, Jaanau Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90007 USA.;Univ Southern Calif, Keck Sch Med, Dept Biochem & Mol Med, Los Angeles, CA 90007 USA.;Univ Southern Calif, Keck Sch Med, Inst Med Genet, Los Angeles, CA 90007 USA.4 aut
700	1	a Heydarpour, Mahyaru Brigham & Womens Hosp, Dept Anesthesiol Perioperat & Pain Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Univ, Harvard Med Sch, Boston, MA 02115 USA.4 aut
700	1	a Pasterkamp, Gerardu Univ Utrecht, UMC Utrecht, Dept Clin Chem, Utrecht, Netherlands.4 aut
700	1	a Kotti, Salmau UPMC, AP HP, Platform Clin Res East Paris, Dept Clin Pharmacol,URCEST,CRCEST,CRB,HUEP, Paris, France.4 aut
700	1	a Kuukasjarvi, Pekkau Tampere Univ, Finnish Cardiovasc Res Ctr Tampere, Fac Med & Hlth Techonol, Dept Cardiothorac Surg, Tampere, Finland.4 aut
700	1	a Lenzini, Petra A.u Washington Univ, Sch Med, Dept Genet, Stat Genom Div, St Louis, MO 63110 USA.4 aut
700	1	a Levin, Danielu Univ Dundee, Sch Med, Div Mol & Clin Med, Dundee, Scotland.4 aut
700	1	a Lyytikainen, Leo-Pekkau Tampere Univ, Finnish Cardiovasc Res Ctr Tampere, Fac Med & Hlth Techonol, Dept Clin Chem, Tampere, Finland.;Fimlab Labs, Dept Clin Chem, Tampere, Finland.4 aut
700	1	a Muehlschlegel, Jochen D.u Brigham & Womens Hosp, Dept Anesthesiol Perioperat & Pain Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Univ, Harvard Med Sch, Boston, MA 02115 USA.4 aut
700	1	a Nelson, Christopher P.u Univ Leicester, Glenfield Hosp, Dept Cardiovasc Sci, BHF Cardiovasc Res Ctr, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England.4 aut
700	1	a Nikus, Kjellu Tampere Univ, Finnish Cardiovasc Res Ctr Tampere, Fac Med & Hlth Techonol, Dept Cardiol, Tampere, Finland.;Tampere Univ Hosp, Heart Ctr, Dept Cardiol, Tampere, Finland.4 aut
700	1	a Pilbrow, Anna P.u Univ Otago Christchurch, Christchurch Heart Inst, Christchurch, New Zealand.4 aut
700	1	a Wilson Tang, W. H.u Cleveland Clin, Dept Cardiovasc & Metab Sci, Lerner Res Inst, Cleveland, OH 44106 USA.;Cleveland Clin, Inst Heart & Vasc, Dept Cardiovasc Med, Cleveland, OH 44106 USA.4 aut
700	1	a van der Laan, Sander W.u Univ Utrecht, UMC Utrecht, Cent Diagnost Lab, Div Labs Pharm & Biomed Genet, Utrecht, Netherlands.4 aut
700	1	a van Setten, Jessicau Univ Utrecht, UMC Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands.4 aut
700	1	a Vilmundarson, Ragnar O.u Univ Ottawa, Heart Inst, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada.;Univ Ottawa, Dept Med & Biochem, Ottawa, ON, Canada.;Univ Ottawa, Dept Microbiol, Ottawa, ON, Canada.;Univ Ottawa, Dept Immunol, Ottawa, ON, Canada.4 aut
700	1	a Deanfield, Johnu UCL, Inst Cardiovasc Sci, 222 Euston Rd, London NW1 2DA, England.;UCL, UCL BHF Res Accelerator, Fac Populat Hlth Sci, London, England.4 aut
700	1	a Deloukas, Panosu Queen Mary Univ London, William Harvey Res Inst, Barts & London Med Sch, London, England.;Queen Mary Univ London, Ctr Genom Hlth, London, England.4 aut
700	1	a Dudbridge, Franku Univ Leicester, Dept Hlth Sci, Leicester, Leics, England.4 aut
700	1	a James, Stefan,d 1964-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)stjam367
700	1	a Mordi, Ify R.u Univ Dundee, Sch Med, Div Mol & Clin Med, Dundee, Scotland.4 aut
700	1	a Teren, Andreju Heart Ctr Leipzig, Leipzig, Germany.;Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany.4 aut
700	1	a Bergmeijer, Thomas O.u St Antonius Hosp, Dept Cardiol, Nieuwegein, Netherlands.4 aut
700	1	a Body, Simon C.u Boston Univ, Sch Med, Dept Anesthesiol, Boston, MA 02118 USA.4 aut
700	1	a Bots, Michielu Univ Utrecht, UMC Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.4 aut
700	1	a Burkhardt, Ralphu Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany.;Univ Hosp Regensburg, Inst Clin Chem & Lab Med, Regensburg, Germany.4 aut
700	1	a Cooper-DeHoff, Rhonda M.u Univ Florida, Dept Pharmacotherapy & Translat Res, Gainesville, FL USA.;Univ Florida, Ctr Pharmacogen, Gainesville, FL USA.;Univ Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL USA.4 aut
700	1	a Cresci, Sharonu Washington Univ, Sch Med, Dept Genet, Stat Genom Div, St Louis, MO 63110 USA.;Washington Univ, Sch Med, Dept Med, Cardiovasc Div, St Louis, MO 63110 USA.4 aut
700	1	a Danchin, Nicolasu Hop Europeen Georges Pompidou, AP HP, FACT French Alliance Cardiovasc Trials, Dept Cardiol, Paris, France.;Univ Paris 05, Paris, France.4 aut
700	1	a Doughty, Robert N.u Univ Auckland, Heart Hlth Res Grp, Auckland, New Zealand.4 aut
700	1	a Grobbee, Diederick E.u Univ Utrecht, UMC Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.4 aut
700	1	a Hagström, Emilu Uppsala universitet,Kardiologi4 aut0 (Swepub:uu)emhag677
700	1	a Hazen, Stanley L.u Cleveland Clin, Dept Cardiovasc & Metab Sci, Lerner Res Inst, Cleveland, OH 44106 USA.;Cleveland Clin, Ctr Microbiome & Human Hlth, Cleveland, OH 44106 USA.4 aut
700	1	a Held, Claes,d 1956-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)clahe947
700	1	a Hoefer, Imo E.u Univ Utrecht, UMC Utrecht, Dept Clin Chem & Hematol, Utrecht, Netherlands.4 aut
700	1	a Hovingh, G. Keesu Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, Amsterdam, Netherlands.4 aut
700	1	a Johnson, Julie A.u Univ Florida, Dept Pharmacotherapy & Translat Res, Gainesville, FL USA.;Univ Florida, Ctr Pharmacogen, Gainesville, FL USA.;Univ Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL USA.4 aut
700	1	a Kaczor, Marcin P.u Jagiellonian Univ, Dept Internal Med, Med Coll, Krakow, Poland.4 aut
700	1	a Kahonen, Mikau Tampere Univ, Finnish Cardiovasc Res Ctr Tampere, Fac Med & Hlth Techonol, Dept Clin Physiol, Tampere, Finland.;Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland.4 aut
700	1	a Klungel, Olaf H.u Univ Utrecht, UMC Utrecht, Div Pharmacoepidemiol & Clin Pharm, Utrecht, Netherlands.4 aut
700	1	a Laurikka, Jari O.u Tampere Univ, Finnish Cardiovasc Res Ctr Tampere, Fac Med & Hlth Techonol, Dept Cardiothorac Surg, Tampere, Finland.;Tampere Univ Hosp, Heart Ctr, Dept Cardiothorac Surg, Tampere, Finland.4 aut
700	1	a Lehtimaki, Terhou Tampere Univ, Finnish Cardiovasc Res Ctr Tampere, Fac Med & Hlth Techonol, Dept Clin Chem, Tampere, Finland.;Fimlab Labs, Dept Clin Chem, Tampere, Finland.4 aut
700	1	a van der Zee, Anke H.u Univ Utrecht, UMC Utrecht, Div Pharmacoepidemiol & Clin Pharm, Utrecht, Netherlands.;Univ Amsterdam, Acad Med Ctr, Dept Resp Med, Amsterdam, Netherlands.4 aut
700	1	a McPherson, Ruthu Univ Ottawa, Dept Med & Biochem, Ottawa, ON, Canada.;Univ Ottawa, Dept Microbiol, Ottawa, ON, Canada.;Univ Ottawa, Dept Immunol, Ottawa, ON, Canada.4 aut
700	1	a Palmer, Colin N.u Ninewells Hosp & Med Sch, Div Mol & Clin Med, Pat Macpherson Ctr Pharmacogenet & Pharmacogen, Dundee, Scotland.4 aut
700	1	a Kraaijeveld, Adriaan O.u Univ Utrecht, UMC Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands.4 aut
700	1	a Pepine, Carl J.u Univ Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL USA.4 aut
700	1	a Sanak, Mareku Jagiellonian Univ, Dept Internal Med, Med Coll, Krakow, Poland.4 aut
700	1	a Sattar, Naveedu Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland.4 aut
700	1	a Scholz, Markusu Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany.;Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany.4 aut
700	1	a Simon, Tabassomeu UPMC, FACT French Alliance Cardiovasc Trials, Platform Clin Res East Paris, Dept Clin Pharmacol,URCEST,CRCEST,CRB,HUEP,AP HP, Paris 06, France.;Sorbonne Univ, Paris 06, France.;Paris Sorbonne Univ, UPMC Site St Antoine, Paris, France.4 aut
700	1	a Spertus, John A.u Univ Missouri, Kansas City, MO 64110 USA.;St Lukes Mid Amer Heart Inst, Kansas City, MO USA.4 aut
700	1	a Stewart, Alexandre F. R.u Univ Ottawa, Heart Inst, Ruddy Canadian Cardiovasc Genet Ctr, Ottawa, ON, Canada.;Univ Ottawa, Dept Med & Biochem, Ottawa, ON, Canada.;Univ Ottawa, Dept Microbiol, Ottawa, ON, Canada.;Univ Ottawa, Dept Immunol, Ottawa, ON, Canada.4 aut
700	1	a Szczeklik, Wojciechu Jagiellonian Univ, Dept Internal Med, Med Coll, Krakow, Poland.4 aut
700	1	a Thiery, Joachimu Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany.;Univ Hosp, Inst Lab Med Clin Chem & Mol Diagnost, Leipzig, Germany.4 aut
700	1	a Visseren, Frank L. J.u Univ Utrecht, UMC Utrecht, Dept Vasc Med, Utrecht, Netherlands.4 aut
700	1	a Waltenberger, Johannesu Univ Munster, Dept Cardiovasc Med, Munster, Germany.4 aut
700	1	a Richards, A. Marku Univ Otago Christchurch, Christchurch Heart Inst, Christchurch, New Zealand.;Natl Univ Singapore, Cardiovasc Res Inst, Singapore, Singapore.4 aut
700	1	a Lang, Chim C.u Univ Dundee, Sch Med, Div Mol & Clin Med, Dundee, Scotland.4 aut
700	1	a Cameron, Vicky A.u Univ Otago Christchurch, Christchurch Heart Inst, Christchurch, New Zealand.4 aut
700	1	a Åkerblom, Axel,d 1977-u Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi4 aut0 (Swepub:uu)axeak985
700	1	a Pare, Guillaumeu McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada.;Populat Hlth Res Inst, Hamilton, ON, Canada.4 aut
700	1	a Maerz, Winfriedu Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Heidelberg, Germany.;Synlab Holding Deutschland GmbH, Synlab Acad, Mannheim, Germany.;Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria.4 aut
700	1	a Samani, Nilesh J.u Univ Leicester, Glenfield Hosp, Dept Cardiovasc Sci, BHF Cardiovasc Res Ctr, Leicester, Leics, England.;Glenfield Hosp, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England.4 aut
700	1	a Hingorani, Aroon D.u UCL, Inst Cardiovasc Sci, 222 Euston Rd, London NW1 2DA, England.;UCL, UCL BHF Res Accelerator, Fac Populat Hlth Sci, London, England.4 aut
700	1	a ten Berg, Jurrien M.u St Antonius Hosp, Dept Cardiol, Nieuwegein, Netherlands.4 aut
700	1	a Wallentin, Lars,d 1943-u Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)larswall
700	1	a Asselbergs, Folkert W.u UCL, Inst Cardiovasc Sci, 222 Euston Rd, London NW1 2DA, England.;Univ Utrecht, UMC Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands.;UCL, UCL BHF Res Accelerator, Fac Populat Hlth Sci, London, England.;UCL, Hlth Data Res UK, London, England.;UCL, Inst Hlth Informat, London, England.4 aut
700	1	a Patel, Riyaz S.u UCL, Inst Cardiovasc Sci, 222 Euston Rd, London NW1 2DA, England.;UCL, UCL BHF Res Accelerator, Fac Populat Hlth Sci, London, England.;St Bartholomews Hosp, Barts Heart Ctr, London, England.4 aut
710	2	a St Antonius Hosp, Dept Cardiol, Nieuwegein, Netherlands.;Univ Groningen, Div Hemostasis & Thrombosis, Dept Hematol, UMC Groningen, Groningen, Netherlands.b Univ Utrecht, UMC Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands.4 org
773	0	t Circulationd : Ovid Technologies (Wolters Kluwer Health)g 142:6, s. 546-555q 142:6<546-555x 0009-7322x 1524-4539
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421550
856	4 8	u https://doi.org/10.1161/CIRCULATIONAHA.119.045526

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Av författaren/redakt...: Mahmoodi, Bakhta ...; Tragante, Vinici ...; Kleber, Marcus E ...; Holmes, Michael ...; Schmidt, Amand F ...; McCubrey, Raymon ...; visa fler...; Howe, Laurence J ...; Direk, Kenan; Allayee, Hooman; Baranova, Ekater ...; Braund, Peter S.; Delgado, Graciel ...; Eriksson, Niclas ...; Gijsberts, Cryst ...; Gong, Yan; Hartiala, Jaana; Heydarpour, Mahy ...; Pasterkamp, Gera ...; Kotti, Salma; Kuukasjarvi, Pek ...; Lenzini, Petra A ...; Levin, Daniel; Lyytikainen, Leo ...; Muehlschlegel, J ...; Nelson, Christop ...; Nikus, Kjell; Pilbrow, Anna P.; Wilson Tang, W. ...; van der Laan, Sa ...; van Setten, Jess ...; Vilmundarson, Ra ...; Deanfield, John; Deloukas, Panos; Dudbridge, Frank; James, Stefan, 1 ...; Mordi, Ify R.; Teren, Andrej; Bergmeijer, Thom ...; Body, Simon C.; Bots, Michiel; Burkhardt, Ralph; Cooper-DeHoff, R ...; Cresci, Sharon; Danchin, Nicolas; Doughty, Robert ...; Grobbee, Diederi ...; Hagström, Emil; Hazen, Stanley L ...; Held, Claes, 195 ...; Hoefer, Imo E.; Hovingh, G. Kees; Johnson, Julie A ...; Kaczor, Marcin P ...; Kahonen, Mika; Klungel, Olaf H.; Laurikka, Jari O ...; Lehtimaki, Terho; van der Zee, Ank ...; McPherson, Ruth; Palmer, Colin N.; Kraaijeveld, Adr ...; Pepine, Carl J.; Sanak, Marek; Sattar, Naveed; Scholz, Markus; Simon, Tabassome; Spertus, John A.; Stewart, Alexand ...; Szczeklik, Wojci ...; Thiery, Joachim; Visseren, Frank ...; Waltenberger, Jo ...; Richards, A. Mar ...; Lang, Chim C.; Cameron, Vicky A ...; Åkerblom, Axel, ...; Pare, Guillaume; Maerz, Winfried; Samani, Nilesh J ...; Hingorani, Aroon ...; ten Berg, Jurrie ...; Wallentin, Lars, ...; Asselbergs, Folk ...; Patel, Riyaz S.; visa färre...

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