CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease

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Fältnamn	Indikatorer	Metadata
000		05126naa a2200517 4500
001		oai:lup.lub.lu.se:49f65881-8c39-41d5-a05d-05d6905165bd
003		SwePub
008		230515s2023 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/49f65881-8c39-41d5-a05d-05d6905165bd2 URI
024	7	a https://doi.org/10.1038/s43587-023-00380-72 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Barthélemy, Nicolas R.u Washington University in St. Louis4 aut
245	1 0	a CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease
264		c 2023-03-13
264	1	b Springer Science and Business Media LLC,c 2023
300		a 11 s.
520		a Cerebrospinal fluid (CSF) amyloid-β peptide (Aβ)42/Aβ40 and the concentration of tau phosphorylated at site 181 (p-tau181) are well-established biomarkers of Alzheimer’s disease (AD). The present study used mass spectrometry to measure concentrations of nine phosphorylated and five nonphosphorylated tau species and phosphorylation occupancies (percentage phosphorylated/nonphosphorylated) at ten sites. In the present study we show that, in 750 individuals with a median age of 71.2 years, CSF pT217/T217 predicted the presence of brain amyloid by positron emission tomography (PET) slightly better than Aβ42/Aβ40 (P = 0.02). Furthermore, for individuals with positive brain amyloid by PET (n = 263), CSF pT217/T217 was more strongly correlated with the amount of amyloid (Spearman’s ρ = 0.69) than Aβ42/Aβ40 (ρ = −0.42, P < 0.0001). In two independent cohorts of participants with symptoms of AD dementia (n = 55 and n = 90), CSF pT217/T217 and pT205/T205 were better correlated with tau PET measures than CSF p-tau181 concentration. These findings suggest that CSF pT217/T217 and pT205/T205 represent improved CSF biomarkers of amyloid and tau pathology in AD.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
700	1	a Saef, Benjaminu Washington University in St. Louis4 aut
700	1	a Li, Yanu Washington University in St. Louis4 aut
700	1	a Gordon, Brian A.u Washington University in St. Louis4 aut
700	1	a He, Yingxinu Washington University in St. Louis4 aut
700	1	a Horie, Kantau Washington University in St. Louis4 aut
700	1	a Stomrud, Eriku Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital4 aut0 (Swepub:lu)med-esr
700	1	a Salvadó, Gemmau Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas4 aut0 (Swepub:lu)ge5655sa
700	1	a Janelidze, Shorenau Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas4 aut0 (Swepub:lu)nkir-sje
700	1	a Sato, Chihirou Washington University in St. Louis4 aut
700	1	a Ovod, Vitaliyu Washington University in St. Louis4 aut
700	1	a Henson, Rachel L.u Washington University in St. Louis4 aut
700	1	a Fagan, Anne M.u Washington University in St. Louis4 aut
700	1	a Benzinger, Tammie L.S.u Washington University in St. Louis4 aut
700	1	a Xiong, Chengjieu Washington University in St. Louis4 aut
700	1	a Morris, John C.u Washington University in St. Louis4 aut
700	1	a Hansson, Oskaru Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital4 aut0 (Swepub:lu)mphy-ohn
700	1	a Bateman, Randall J.u Washington University in St. Louis4 aut
700	1	a Schindler, Suzanne E.u Washington University in St. Louis4 aut
710	2	a Washington University in St. Louisb Klinisk minnesforskning4 org
773	0	t Nature Agingd : Springer Science and Business Media LLCg 3:4, s. 391-401q 3:4<391-401x 2662-8465
856	4	u http://dx.doi.org/10.1038/s43587-023-00380-7x freey FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/49f65881-8c39-41d5-a05d-05d6905165bd
856	4 8	u https://doi.org/10.1038/s43587-023-00380-7

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