Search: WFRF:(Jansson Caroline) >
Chronic airway obst...
Chronic airway obstruction in a population-based adult asthma cohort : Prevalence, incidence and prognostic factors
-
- Backman, Helena (author)
- Umeå universitet,Yrkes- och miljömedicin,the OLIN Unit, Umeå University, Umeå, Sweden.,Department of Public Health and Clinical Medicine, Division of Occupational and Environmental Medicine, The OLIN Unit, Umeå University
-
- Jansson, Sven-Arne (author)
- Umeå universitet,Yrkes- och miljömedicin,the OLIN Unit, Umeå University, Umeå, Sweden.,Department of Public Health and Clinical Medicine, Division of Occupational and Environmental Medicine/the OLIN Unit, Umeå University
-
- Stridsman, Caroline (author)
- Luleå tekniska universitet,Omvårdnad,Department of Health Sciences, Luleå University, Luleå, Sweden
-
show more...
-
- Muellerova, Hana (author)
- Real-World Evidence&Epidemiology, GSK R&D, Uxbridge, UK
-
- Wurst, Keele (author)
- Real-World Evidence&Epidemiology, GSK R&D, Uxbridge, UK
-
- Hedman, Linnea (author)
- Umeå universitet,Yrkes- och miljömedicin,Department of Health Sciences, Luleå University, Luleå, Sweden,the OLIN Unit, Umeå University, Umeå, Sweden.,Department of Public Health and Clinical Medicine, Division of Occupational and Environmental Medicine/the OLIN Unit, Umeå University
-
- Lindberg, Anne (author)
- Umeå universitet,Medicin,the OLIN Unit, Umeå University, Umeå, Sweden.,Department of Public Health and Clinical Medicine, Division of Medicine/the OLIN Unit, Umeå University
-
- Rönmark, Eva (author)
- Umeå universitet,Yrkes- och miljömedicin,the OLIN Unit, Umeå University, Umeå, Sweden.,Department of Public Health and Clinical Medicine, Division of Occupational and Environmental Medicine/the OLIN Unit, Umeå University
-
show less...
-
(creator_code:org_t)
- Elsevier, 2018
- 2018
- English.
-
In: Respiratory Medicine. - : Elsevier. - 0954-6111 .- 1532-3064. ; 138, s. 115-122
- Related links:
-
http://www.resmedjou...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- BackgroundAsthma and COPD may overlap (ACO) but information about incidence and risk factors are lacking. This study aimed to estimate prevalence, incidence and risk factors of chronic airway obstruction (CAO) in a population-based adult asthma cohort.MethodsDuring 1986–2001 a large population-based asthma cohort was identified (n = 2055, 19-72y). Subsamples have participated in clinical follow-ups during the subsequent years. The entire cohort was invited to a clinical follow-up including interview, spirometry, and blood sampling in 2012–2014 when n = 983 subjects performed adequate spirometry. CAO was defined as post-bronchodilator FEV1/FVC<0.7.ResultsAt study entry, asthmatics with prevalent CAO (11.4%) reported more respiratory symptoms, asthma medication use, and ischemic heart disease than asthmatics without CAO (asthma only). Subjects who developed CAO during follow-up (17.6%; incidence rate of 16/1000/year) had a more rapid FEV1 decline and higher levels of neutrophils than asthma only. Smoking, older age and male sex were independently associated with increased risk for both prevalent and incident CAO, while obesity had a protective effect.ConclusionsIn this prospective adult asthma cohort, the majority did not develop CAO. Smoking, older age and male sex were risk factors for prevalent and incident CAO, similar to risk factors described for COPD in the general population.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Annan hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Other Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Nursing
- Omvårdnad
- Health Science
- Hälsovetenskap
- ACO
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database