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Functional outcomes...
Functional outcomes associated with varying levels of targeted temperature management after out-of-hospital cardiac arrest — An INTCAR2 registry analysis
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- Johnsson, Jesper (författare)
- Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Helsingborg Hospital
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- Wahlström, Josefine (författare)
- Skåne University Hospital
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- Dankiewicz, Josef (författare)
- Skåne University Hospital
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- Annborn, Martin (författare)
- Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Helsingborg Hospital
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- Agarwal, Sachin (författare)
- Columbia University
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- Dupont, Allison (författare)
- The Mount Sinai Medical Center
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- Forsberg, Sune (författare)
- Karolinska Institutet,Stockholm County Council
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- Friberg, Hans (författare)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,SWECRIT,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital
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- Hand, Robert (författare)
- Eastern Maine Medical Center
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- Hirsch, Karen G. (författare)
- Stanford University
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- May, Teresa (författare)
- Maine Medical Center
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- McPherson, John A. (författare)
- Vanderbilt University
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- Mooney, Michael R. (författare)
- Minneapolis Heart Institute
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- Patel, Nainesh (författare)
- Lehigh Valley Hospital
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- Riker, Richard R. (författare)
- Maine Medical Center
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- Stammet, Pascal (författare)
- National Fire and Rescue Corps
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- Søreide, Eldar (författare)
- University of Bergen,Stavanger University Hospital
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- Seder, David B. (författare)
- Maine Medical Center
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- Nielsen, Niklas (författare)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Kliniska Vetenskaper, Helsingborg,Institutionen för kliniska vetenskaper, Lund,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,SEBRA Sepsis and Bacterial Resistance Alliance,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Sciences, Helsingborg,Department of Clinical Sciences, Lund,Center for cardiac arrest,Lund University Research Groups,Helsingborg Hospital
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska 8 s.
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Ingår i: Resuscitation. - : Elsevier BV. - 0300-9572 .- 1873-1570. ; 146, s. 229-236
- Relaterad länk:
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http://dx.doi.org/10... (free)
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http://www.resuscita...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Introduction: Targeted temperature management (TTM) after out-of-hospital cardiac arrest (OHCA) has been recommended in international guidelines since 2005. The TTM-trial published in 2013 showed no difference in survival or neurological outcome for patients randomised to 33 °C or 36 °C, and many hospitals have changed practice. The optimal utilization of TTM is still debated. This study aimed to analyse if a difference in temperature goal was associated with outcome in an unselected international registry population. Methods: This is a retrospective observational study based on a prospective registry — the International Cardiac Arrest Registry 2. Patients were categorized as receiving TTM in the lower range at 32–34 °C (TTM-low) or at 35–37 °C (TTM-high). Primary outcome was good functional status defined as cerebral performance category (CPC) of 1–2 at hospital discharge and secondary outcome was adverse events related to TTM. A logistic regression model was created to evaluate the independent effect of temperature by correcting for clinical and demographic factors associated with outcome. Results: Of 1710 patients included, 1242 (72,6%) received TTM-low and 468 (27,4%) TTM-high. In patients receiving TTM-low, 31.3% survived with good outcome compared to 28.8% in the TTM-high group. There was no significant association between temperature and outcome (p = 0.352). In analyses adjusted for baseline differences the OR for a good outcome with TTM-low was 1.27, 95% CI (0.94–1.73). Haemodynamic instability leading to discontinuation of TTM was more common in TTM-low. Conclusions: No significant difference in functional outcome at hospital discharge was found in patients receiving lower- versus higher targeted temperature management.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Cardiac arrest
- Out-of-hospital
- Outcome
- Targeted temperature management
- TTM
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Johnsson, Jesper
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Wahlström, Josef ...
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Dankiewicz, Jose ...
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Annborn, Martin
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Agarwal, Sachin
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Dupont, Allison
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visa fler...
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Forsberg, Sune
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Friberg, Hans
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Hand, Robert
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Hirsch, Karen G.
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May, Teresa
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McPherson, John ...
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Mooney, Michael ...
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Patel, Nainesh
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Riker, Richard R ...
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Stammet, Pascal
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Søreide, Eldar
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Seder, David B.
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Nielsen, Niklas
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Resuscitation
- Av lärosätet
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Lunds universitet
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Karolinska Institutet