Treatment-related deaths in second complete remission in childhood acute myeloid leukaemia.

• The frequency and causes of treatment-related deaths (TRD) in second complete remission (CR2) in acute myeloid leukaemia (AML) were investigated in a historical, prospective cohort study of 429 children included in the Nordic Society of Paediatric Haematology and Oncology (NOPHO)-AML-88 and -93 trials. Relapse occurred in 158 children (39%). Seventeen (18%) of the 96 patients entering CR2 suffered TRD. The main causes were infection (59%) and complications from graft-versus-host disease (22%). Fourteen (82%) of 17 TRDs occurred in children undergoing haematopoietic stem cell transplantations (HSCT). Optimal supportive care after HSCT is essential, and studies on risk factors for TRD are needed.

Ämnesord

SAMHÄLLSVETENSKAP  -- Annan samhällsvetenskap -- Övrig annan samhällsvetenskap (hsv//swe)

SOCIAL SCIENCES  -- Other Social Sciences -- Other Social Sciences not elsewhere specified (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Adolescent

Antineoplastic Combined Chemotherapy Protocols

adverse effects

therapeutic use

Child

Child

Preschool

Disease Progression

Epidemiologic Methods

Female

Graft vs Host Disease

mortality

Hematopoietic Stem Cell Transplantation

adverse effects

Humans

Infant

Leukemia

Myeloid

Acute

drug therapy

mortality

Male

Opportunistic Infections

mortality

Recurrence

Remission Induction

Scandinavia

epidemiology

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)