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WFRF:(Lopez Jose Manuel)
 

Sökning: WFRF:(Lopez Jose Manuel) > In Vitro Anticancer...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004764naa a2200565 4500
001oai:DiVA.org:uu-469184
003SwePub
008220307s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4691842 URI
0247 a https://doi.org/10.3390/biomedicines100100412 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Burgos-Moron, Estefaniau Univ Seville, Fac Pharm, Dept Pharmacol, Seville 41012, Spain.4 aut
2451 0a In Vitro Anticancer Activity and Mechanism of Action of an Aziridinyl Galactopyranoside
264 c 2021-12-25
264 1b MDPI AG,c 2022
338 a electronic2 rdacarrier
520 a We recently screened a series of new aziridines beta-D-galactopyranoside derivatives for selective anticancer activity and identified 2-methyl-2,3-[N-(4-methylbenzenesulfonyl)imino]propyl 2,3-di-O-benzyl-4,6-O-(S)-benzylidene-beta-D-galactopyranoside (AzGalp) as the most promising compound. In this article, we explore the possible mechanisms involved in the cytotoxicity of this aziridine and evaluate its selective anticancer activity using cancer cells and normal cells from a variety of tissues. Our data show that AzGalp induces DNA damage (comet assay). Cells deficient in the nucleotide excision repair (NER) pathway were hypersensitive to the cytotoxicity of this compound. These results suggest that AzGalp induces bulky DNA adducts, and that cancer cells lacking a functional NER pathway may be particularly vulnerable to the anticancer effects of this aziridine. Several experiments revealed that neither the generation of oxidative stress nor the inhibition of glycolysis played a significant role in the cytotoxicity of AzGalp. Combinations of AzGalp with oxaliplatin or 5-fluorouracil slightly improved the ability of both anticancer drugs to selectively kill cancer cells. AzGalp also showed selective cytotoxicity against a panel of malignant cells versus normal cells; the highest selectivity was observed for two acute promyelocytic leukemia cell lines. Additional preclinical studies are necessary to evaluate the anticancer potential of AzGalp.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a TEKNIK OCH TEKNOLOGIERx Nanoteknik0 (SwePub)2102 hsv//swe
650 7a ENGINEERING AND TECHNOLOGYx Nano-technology0 (SwePub)2102 hsv//eng
653 a aziridine
653 a cancer
653 a cytotoxic
653 a cytotoxicity
653 a selectivity
653 a nucleotide excision repair
653 a Engineering Science with specialization in Nanotechnology and Functional Materials
653 a Teknisk fysik med inriktning mot nanoteknologi och funktionella material
7001 a Pastor, Nuriau Univ Seville, Fac Biol, Dept Cell Biol, Seville 41012, Spain.4 aut
7001 a Orta, Manuel Luisu Univ Seville, Fac Biol, Dept Cell Biol, Seville 41012, Spain.4 aut
7001 a Jimenez-Alonso, Julio Joseu Univ Seville, Fac Pharm, Dept Pharmacol, Seville 41012, Spain.4 aut
7001 a Palo-Nieto, Carlosu Uppsala universitet,Nanoteknologi och funktionella material,Institutionen för läkemedelskemi,Univ Seville, Fac Pharm, Dept Organ & Med Chem, Seville 41012, Spain.4 aut0 (Swepub:uu)carpa373
7001 a Vega-Holm, Margaritau Univ Seville, Fac Pharm, Dept Organ & Med Chem, Seville 41012, Spain.4 aut
7001 a Vega-Perez, Jose Manuelu Univ Seville, Fac Pharm, Dept Organ & Med Chem, Seville 41012, Spain.4 aut
7001 a Iglesias-Guerra, Fernandou Univ Seville, Fac Pharm, Dept Organ & Med Chem, Seville 41012, Spain.4 aut
7001 a Mateos, Santiagou Univ Seville, Fac Biol, Dept Cell Biol, Seville 41012, Spain.4 aut
7001 a Lopez-Lazaro, Miguelu Univ Seville, Fac Pharm, Dept Pharmacol, Seville 41012, Spain.4 aut
7001 a Calderon-Montano, Jose Manuelu Univ Seville, Fac Pharm, Dept Pharmacol, Seville 41012, Spain.4 aut
7102 a Univ Seville, Fac Pharm, Dept Pharmacol, Seville 41012, Spain.b Univ Seville, Fac Biol, Dept Cell Biol, Seville 41012, Spain.4 org
7730 t Biomedicinesd : MDPI AGg 10:1q 10:1x 2227-9059
8564 u https://doi.org/10.3390/biomedicines10010041y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1642716/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.mdpi.com/2227-9059/10/1/41/pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-469184
8564 8u https://doi.org/10.3390/biomedicines10010041

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