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Biocompliant Composite Au/pHEMA Plasmonic Scaffolds for 3D Cell Culture and Noninvasive Sensing of Cellular Metabolites
- Lehman, S E (författare)
- McCracken, J M (författare)
- Miller, L A (författare)
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- Jayalath, S (författare)
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- (creator_code:org_t)
- 2020-09-09
- 2020
- Engelska.
- Ingår i: Advanced Healthcare Materials. - : Wiley-VCH Verlag. - 2192-2640 .- 2192-2659.
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- The field of 3D printing is an area of active research, with a substantial focus given to the design and construction of customized tools for applications in technology. There exists a particular need in these developing areas of opportunity for new multi-functional soft materials that are biologically compatible for the growth and directed culturing of cells. Herein, a composite material consisting of gold nanoparticles with useful plasmonic properties embedded within a highly hydrophilic poly-2-hydroxyethylmethacrylate matrix is described and characterized. This composite material serves dual functions as both host framework scaffold for cell lines such as pre-osteoblasts as well as a plasmonic biosensor for in situ measurements of living cells. The plasmonic properties of this system are characterized as a function of the material properties and related to compositional features of the material through a proposed light-directed mechanism. This chemistry provides a tunable, 3D printable plasmonic composite material of encapsulated gold nanoparticles in a biologically-compliant, acrylate-based hydrogel matrix. Surface-enhanced Raman scattering studies of 3D-microcultures supported by the scaffolds are carried out and the strong influence of perm-selective molecular diffusion in its analytical responses is established. Most notably, specific, largely hydrophilic, cellular metabolites are detected within the supported live cultures.
Ämnesord
- NATURVETENSKAP -- Fysik -- Den kondenserade materiens fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Condensed Matter Physics (hsv//eng)
Nyckelord
- 3D printers
- 3D printing
- Cell culture
- Cells
- Cellular metabolites
- Composite materials
- Compositional features
- Design and construction
- Fiber optic sensors
- Gold nanoparticles
- Hydrophilicity
- Hydroxyethylmethacrylate
- Metabolites
- Metal nanoparticles
- Non-invasive sensing
- Plasmonic biosensors
- Plasmonic nanoparticles
- Plasmonic properties
- Plasmonics
- Raman scattering
- SERS
- Scaffolds (biology)
- Soft materials
- Surface enhanced Raman Scattering (SERS)
- Surface scattering
- bio-compliant
- biomimetics
- gels
- plasmonic sensing
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- ref (ämneskategori)
- art (ämneskategori)
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- Lehman, S E
- McCracken, J M
- Miller, L A
- Jayalath, S
- Nuzzo, Ralph G.
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