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  • Wang, RuiKarolinska Institutet,Gymnastik- och idrottshögskolan,Institutionen för fysisk aktivitet och hälsa,University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Karolinska Institutet and Stockholm University, Stockholm, Sweden,Fysisk aktivitet och hjärnhälsa (författare)

Impact of sex and APOE ε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults : A longitudinal study.

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • Sage Publications,2021
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:gih-6750
  • https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-6750URI
  • https://doi.org/10.1177/0271678X211021313DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:147271398URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Cerebral hypoperfusion is thought to contribute to cognitive decline in Alzheimer's disease, but the natural trajectory of cerebral perfusion in cognitively healthy adults has not been well-studied. This longitudinal study is consisted of 950 participants (40-89 years), who were cognitively unimpaired at their first visit. We investigated the age-related changes in cerebral perfusion, and their associations with APOE-genotype, biological sex, and cardiometabolic measurements. During the follow-up period (range 0.13-8.24 years), increasing age was significantly associated with decreasing cerebral perfusion, in total gray-matter (β=-1.43), hippocampus (-1.25), superior frontal gyrus (-1.70), middle frontal gyrus (-1.99), posterior cingulate (-2.46), and precuneus (-2.14), with all P-values < 0.01. Compared with male-ɛ4 carriers, female-ɛ4 carriers showed a faster decline in global and regional cerebral perfusion with increasing age, whereas the age-related decline in cerebral perfusion was similar between male- and female-ɛ4 non-carriers. Worse cardiometabolic profile (i.e., increased blood pressure, body mass index, total cholesterol, and blood glucose) was associated with lower cerebral perfusion at all the visits. When time-varying cardiometabolic measurements were adjusted in the model, the synergistic effect of sex and APOE-ɛ4 on age-related cerebral perfusion-trajectories became largely attenuated. Our findings demonstrate that APOE-genotype and sex interactively impact cerebral perfusion-trajectories in mid- to late-life. This effect may be partially explained by cardiometabolic alterations.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Oh, Jennifer MUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Middleton Memorial Veterans Hospital, Madison, WI, USA. (författare)
  • Motovylyak, AliceUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA (författare)
  • Ma, YueUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA (författare)
  • Sager, Mark AUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA (författare)
  • Rowley, Howard AUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA (författare)
  • Johnson, Kevin MUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA (författare)
  • Gallagher, Catherine LUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA (författare)
  • Carlsson, Cynthia MUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA (författare)
  • Bendlin, Barbara BUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA (författare)
  • Johnson, Sterling CUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA (författare)
  • Asthana, SanjayUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA (författare)
  • Eisenmenger, LauraUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA (författare)
  • Okonkwo, Ozioma CUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA (författare)
  • Gymnastik- och idrottshögskolanInstitutionen för fysisk aktivitet och hälsa (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Cerebral Blood Flow and Metabolism: Sage Publications41:11, s. 3016-30270271-678X1559-7016

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