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Sökning: WFRF:(Oh Jennifer M) > Impact of sex and A...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005536naa a2200577 4500
001oai:DiVA.org:gih-6750
003SwePub
008210701s2021 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:147271398
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-67502 URI
0247 a https://doi.org/10.1177/0271678X2110213132 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1472713982 URI
040 a (SwePub)gihd (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Wang, Ruiu Karolinska Institutet,Gymnastik- och idrottshögskolan,Institutionen för fysisk aktivitet och hälsa,University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Karolinska Institutet and Stockholm University, Stockholm, Sweden,Fysisk aktivitet och hjärnhälsa4 aut0 (Swepub:gih)rui.wang
2451 0a Impact of sex and APOE ε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults :b A longitudinal study.
264 1b Sage Publications,c 2021
338 a electronic2 rdacarrier
520 a Cerebral hypoperfusion is thought to contribute to cognitive decline in Alzheimer's disease, but the natural trajectory of cerebral perfusion in cognitively healthy adults has not been well-studied. This longitudinal study is consisted of 950 participants (40-89 years), who were cognitively unimpaired at their first visit. We investigated the age-related changes in cerebral perfusion, and their associations with APOE-genotype, biological sex, and cardiometabolic measurements. During the follow-up period (range 0.13-8.24 years), increasing age was significantly associated with decreasing cerebral perfusion, in total gray-matter (β=-1.43), hippocampus (-1.25), superior frontal gyrus (-1.70), middle frontal gyrus (-1.99), posterior cingulate (-2.46), and precuneus (-2.14), with all P-values < 0.01. Compared with male-ɛ4 carriers, female-ɛ4 carriers showed a faster decline in global and regional cerebral perfusion with increasing age, whereas the age-related decline in cerebral perfusion was similar between male- and female-ɛ4 non-carriers. Worse cardiometabolic profile (i.e., increased blood pressure, body mass index, total cholesterol, and blood glucose) was associated with lower cerebral perfusion at all the visits. When time-varying cardiometabolic measurements were adjusted in the model, the synergistic effect of sex and APOE-ɛ4 on age-related cerebral perfusion-trajectories became largely attenuated. Our findings demonstrate that APOE-genotype and sex interactively impact cerebral perfusion-trajectories in mid- to late-life. This effect may be partially explained by cardiometabolic alterations.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a APOE gene
653 a Alzheimer’s disease
653 a Cerebral perfusion
653 a cardiometabolic measurements
653 a chromosomal sex
653 a Medicin/Teknik
653 a Medicine/Technology
7001 a Oh, Jennifer Mu University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Middleton Memorial Veterans Hospital, Madison, WI, USA.4 aut
7001 a Motovylyak, Aliceu University of Wisconsin School of Medicine and Public Health, Madison, WI, USA4 aut
7001 a Ma, Yueu University of Wisconsin School of Medicine and Public Health, Madison, WI, USA4 aut
7001 a Sager, Mark Au University of Wisconsin School of Medicine and Public Health, Madison, WI, USA4 aut
7001 a Rowley, Howard Au University of Wisconsin School of Medicine and Public Health, Madison, WI, USA4 aut
7001 a Johnson, Kevin Mu University of Wisconsin School of Medicine and Public Health, Madison, WI, USA4 aut
7001 a Gallagher, Catherine Lu University of Wisconsin School of Medicine and Public Health, Madison, WI, USA4 aut
7001 a Carlsson, Cynthia Mu University of Wisconsin School of Medicine and Public Health, Madison, WI, USA4 aut
7001 a Bendlin, Barbara Bu University of Wisconsin School of Medicine and Public Health, Madison, WI, USA4 aut
7001 a Johnson, Sterling Cu University of Wisconsin School of Medicine and Public Health, Madison, WI, USA4 aut
7001 a Asthana, Sanjayu University of Wisconsin School of Medicine and Public Health, Madison, WI, USA4 aut
7001 a Eisenmenger, Laurau University of Wisconsin School of Medicine and Public Health, Madison, WI, USA4 aut
7001 a Okonkwo, Ozioma Cu University of Wisconsin School of Medicine and Public Health, Madison, WI, USA4 aut
7102 a Gymnastik- och idrottshögskolanb Institutionen för fysisk aktivitet och hälsa4 org
7730 t Journal of Cerebral Blood Flow and Metabolismd : Sage Publicationsg 41:11, s. 3016-3027q 41:11<3016-3027x 0271-678Xx 1559-7016
8564 u https://doi.org/10.1177/0271678X211021313y Fulltext
8564 u https://gih.diva-portal.org/smash/get/diva2:1576860/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-6750
8564 8u https://doi.org/10.1177/0271678X211021313
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:147271398

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