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  • Romu, ThobiasLinköpings universitet,Medicinsk informatik,Tekniska högskolan,Centrum för medicinsk bildvetenskap och visualisering, CMIV (author)

Characterization of Brown Adipose Tissue by Water-Fat Separated Magnetic Resonance Imaging

  • Article/chapterEnglish2015

Publisher, publication year, extent ...

  • 2015-04-25
  • Wiley,2015

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/232876
  • https://gup.ub.gu.se/publication/232876URI
  • https://doi.org/10.1002/jmri.24931DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-116931URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: To evaluate the possibility of quantifying brown adipose tissue (BAT) volume and fat concentration with a high resolution, long echo time, dual-echo Dixon imaging protocol. Methods: A 0.42 mm isotropic resolution water-fat separated MRI protocol was implemented by using the second opposite-phase echo and third in-phase echo. Fat images were calibrated with regard to the intensity of nearby white adipose tissue (WAT) to form relative fat content (RFC) images. To evaluate the ability to measure BAT volume and RFC contrast dynamics, rats were divided into two groups that were kept at 48 or 22 degrees C for 5 days. The rats were then scanned in a 70 cm bore 3.0 Tesla MRI scanner and a human dual energy CT. Interscapular, paraaortal, and perirenal BAT (i/pa/pr-BAT) depots as well as WAT and muscle were segmented in the MRI and CT images. Biopsies were collected from the identified BAT depots. Results: The biopsies confirmed that the three depots identified with the RFC images consisted of BAT. There was a significant linear correlation (P< 0.001) between the measured RFC and the Hounsfield units from DECT. Significantly lower iBAT RFC (P=0.0064) and significantly larger iBAT and prBAT volumes (P=0.0017) were observed in the cold stimulated rats. Conclusion: The calibrated Dixon images with RFC scaling can depict BAT and be used to measure differences in volume, and fat concentration, induced by cold stimulation. The high correlation between RFC and HU suggests that the fat concentration is the main RFC image contrast mechanism.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Elander, LouiseLinköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten(Swepub:liu)louka86 (author)
  • Dahlqvist Leinhard, OlofLinköpings universitet,Avdelningen för radiologiska vetenskaper,Hälsouniversitetet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Radiofysikavdelningen US(Swepub:liu)oloda24 (author)
  • Lidell, Martin,1970Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics(Swepub:gu)xlidma (author)
  • Betz, Mattias J.Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,Klinikum der Ludwig Maximilians University, Munich (author)
  • Persson, AndersLinköpings universitet,Avdelningen för radiologiska vetenskaper,Hälsouniversitetet,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Röntgenkliniken i Linköping(Swepub:liu)andpe75 (author)
  • Enerbäck, Sven,1958Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics(Swepub:gu)xenesv (author)
  • Borga, MagnusLinköpings universitet,Medicinsk informatik,Tekniska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV(Swepub:liu)magbo72 (author)
  • Linköpings universitetMedicinsk informatik (creator_code:org_t)

Related titles

  • In:Journal of Magnetic Resonance Imaging: Wiley42:6, s. 1639-16451053-18071522-2586

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