Leukotriene and prostanoid pathway enzymes in bronchial biopsies of seasonal allergic asthmatics

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Sökning: WFRF:(Riise Gerdt C. 1956) > (2000-2004) > Leukotriene and pro...

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Fältnamn	Indikatorer	Metadata
000		04300naa a2200625 4500
001		oai:gup.ub.gu.se/45045
003		SwePub
008		240528s2001 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/450452 URI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Seymour, M. L.4 aut
245	1 0	a Leukotriene and prostanoid pathway enzymes in bronchial biopsies of seasonal allergic asthmatics
264	1	c 2001
520		a Cysteinyl-leukotrienes and prostaglandin D2 generated by the 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways, respectively, cause bronchoconstriction, leukocyte recruitment, and bronchial hyperresponsiveness in asthma. We characterized the cellular expression of 5-LO and COX enzymes using immunohistochemistry on bronchial biopsies from 12 allergic asthmatic patients before and during seasonal exposure to birch pollen. Bronchial responsiveness (p = 0.004) and symptoms (p < 0.005) increased and peak expiratory flow (PEF; p < or = 0.02) decreased in the pollen season. In-season biopsies had 2-fold more cells immunostaining for 5-LO (p = 0.02), 5-LO-activating protein (FLAP; p = 0.04), and leukotriene (LT)A4 hydrolase (p = 0.05), and 4-fold more for the terminal enzyme for cysteinyl-leukotriene synthesis, LTC4 synthase (p = 0.02). Immunostaining for COX-1, COX-2, and PGD2 synthase was unchanged. Increased staining for LTC4 synthase was due to increased eosinophils (p = 0.035) and an increased proportion of eosinophils expressing the enzyme (p = 0.047). Macrophages also increased (p = 0.019), but mast cells and T-lymphocyte subsets were unchanged. Inverse correlations between PEF and 5-LO(+) cell counts link increased expression of 5-LO pathway enzymes in eosinophils and macrophages within the bronchial mucosa to deterioration of lung function during seasonal allergen exposure.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Dermatologi och venereologi0 (SwePub)302042 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dermatology and Venereal Diseases0 (SwePub)302042 hsv//eng
653		a Adult
653		a Air Pollution/adverse effects/analysis
653		a Arachidonate 5-Lipoxygenase/analysis/immunology/metabolism
653		a Asthma/etiology/metabolism/pathology/physiopathology
653		a Biopsy
653		a Bronchial Hyperreactivity/etiology/metabolism/pathology/physiopathology
653		a Eosinophils/immunology
653		a Forced Expiratory Volume
653		a Humans
653		a Hypersensitivity/etiology/metabolism/pathology/physiopathology
653		a Immunohistochemistry
653		a Leukocyte Count
653		a Leukotrienes/analysis/immunology/metabolism
653		a Macrophages/immunology
653		a Mast Cells/immunology
653		a Peak Expiratory Flow Rate
653		a Pollen/*adverse effects
653		a Prostaglandin-Endoperoxide Synthases/analysis/immunology/metabolism
653		a Prostaglandins/analysis/immunology/metabolism
653		a *Seasons
653		a Severity of Illness Index
653		a Sweden
653		a T-Lymphocytes/immunology
653		a Trees
700	1	a Rak, Sabina,d 1945u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine4 aut0 (Swepub:gu)xraksa
700	1	a Åberg, Daniel,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine4 aut0 (Swepub:gu)xaberd
700	1	a Riise, Gerdt C.,d 1956u Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi,Institute of Internal Medicine, Dept of Respiratory Medicine/Allergology4 aut0 (Swepub:gu)xriige
700	1	a Penrose, J. F.4 aut
700	1	a Kanaoka, Y.4 aut
700	1	a Austen, K. F.4 aut
700	1	a Holgate, S. T.4 aut
700	1	a Sampson, A. P.4 aut
710	2	a Göteborgs universitetb Institutionen för invärtesmedicin4 org
773	0	t Am J Respir Crit Care Medg 164:11, s. 2051-6q 164:11<2051-6x 1073-449X
856	4 8	u https://gup.ub.gu.se/publication/45045

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