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Results of patch testing with five fragrance materials hitherto not tested : A dose-finding study in the clinical population

Sukakul, Thanisorn (författare)
Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups
Uter, Wolfgang (författare)
Friedrich-Alexander University Erlangen-Nürnberg
Gonçalo, Margarida (författare)
University Hospital of Coimbra
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Huggard, Joseph (författare)
Ljubojević Hadžavdić, Suzana (författare)
University Hospital Centre Zagreb
Schuttelaar, Marie L.A. (författare)
University Medical Center Groningen
Svedman, Cecilia (författare)
Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups
Vey, Matthias (författare)
Isaksson, Marléne (författare)
Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups
Niklasson, Bo (författare)
Rustemeyer, Thomas (författare)
Academic Medical Center of University of Amsterdam (AMC)
Bruze, Magnus (författare)
Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups
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 (creator_code:org_t)
Engelska.
Ingår i: Contact Dermatitis. - 0105-1873.
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Quantitative risk assessment (QRA) for skin sensitization is used to derive safe use levels of sensitising fragrance ingredients in products. Post-marketing surveillance of the prevalence of contact allergy to these ingredients provides relevant data to help evaluate the performance of these measures. Objectives: To determine a suitable patch test concentration for five fragrance materials that had hitherto not been tested on a regular basis. These concentrations are then to be used in a surveillance study with patch testing consecutive patients over an extended monitoring period. Materials and Methods: Furaneol, CAS.3658-77-3; trans-2-hexenal, CAS.6728-26-3; 4,8-dimethyl-4,9-decadienal, CAS.71077-31-1; longifolene, CAS.475-20-7; benzaldehyde, CAS.10052-7, were patch tested with other fragrance allergens in four clinics. Patch testing was conducted in three rounds, starting with the lowest concentrations of the five ingredients. The doses were increased in the subsequent rounds if no late-appearing positive reactions and virtually no irritant reactions were reported. Results: Overall, 373 patients were tested. No positive allergic reaction was reported to the five ingredients. Patch test results of other fragrance allergens are reported. Conclusions: The highest test concentrations are each considered safe for patch testing consecutive patients. Further surveillance based on these preparations will evaluate the hypothesis that QRA-driven consumer product levels of these fragrances can prevent sensitization.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)

Nyckelord

4,8-dimethyl-4,9-decadienal (CAS 71077-31-1)
allergic contact dermatitis
benzaldehyde (CAS 100–52-7)
fragrance contact allergy
furaneol (CAS 3658-77-3)
longifolene (CAS 475–20-7)
quantitative risk assessment
skin sensitization
trans-2-hexenal (CAS 6728-26-3)

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