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Social genetic effe...
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Salvatore, Jessica E.Rutgers Robert Wood Johnson Medical School
(författare)
Social genetic effects for drug use disorder among spouses
- Artikel/kapitelEngelska2023
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LIBRIS-ID:oai:lup.lub.lu.se:d995f1bf-3479-451f-94ea-5fe7630f020d
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https://lup.lub.lu.se/record/d995f1bf-3479-451f-94ea-5fe7630f020dURI
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https://doi.org/10.1111/add.16108DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Aims: Preclinical and human studies suggest that a social partner's genotype may be associated with addiction-related outcomes. This study measured whether spousal genetic makeup is associated with risk of developing drug use disorder (DUD) during marriage and whether the risk associated with a spouse's genotype could be disentangled from potentially confounding rearing environmental effects. Design: Univariable and multivariable logistic regression analyses. Setting: Sweden. Participants: Men and women born between 1960 and 1990 and in opposite-sex first marriages before age 35 (n = 294 748 couples). Measurements: Outcome was DUD diagnosis (inclusive of opioids, sedatives/hypnotics/anxiolytics, cocaine, cannabis, amphetamine and other psychostimulants, hallucinogens, other drugs of abuse and combinations thereof) obtained from legal, medical and pharmacy registries. The focal predictor was family genetic risk scores for DUD (FGRS-DUD), which were inferred from diagnoses in first- through fifth-degree relatives and weighted by degree of genetic sharing. FGRS-DUD were calculated separately for each partner in a couple. Findings: Marriage to a spouse with a high FGRS-DUD was associated with increased risk of developing DUD during marriage, ORmales = 1.68 (95% CI = 1.50, 1.88) and ORfemales = 1.35 (1.16, 1.56), above and beyond the risk associated with one's own FGRS-DUD. The risk associated with a spouse's FGRS-DUD remained statistically significant after covarying for parental education. As indicated by a series of null interaction effects, there was no evidence that the risk associated with a spouse's FGRS-DUD differed depending on whether the spouse was DUD-affected, probands' probable contact with in-laws and whether the spouse was raised by his/her biological parents or in another home. Conclusions: There is relatively robust evidence that a person's risk for developing drug use disorder is associated with the genetic makeup of the person's spouse.
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Larsson Lönn, SaraLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Center for Primary Health Care Research(Swepub:lu)mats-sla
(författare)
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Sundquist, JanLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Family Medicine and Clinical Epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Center for Primary Health Care Research(Swepub:lu)med-jsu
(författare)
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Kendler, Kenneth S.Virginia Commonwealth University
(författare)
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Sundquist, KristinaLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Family Medicine and Clinical Epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Center for Primary Health Care Research(Swepub:lu)med-ksq
(författare)
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Rutgers Robert Wood Johnson Medical SchoolAllmänmedicin och klinisk epidemiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Addiction: Wiley118:5, s. 880-8890965-21401360-0443
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