WFRF:(Salvatore Jessica E.)
Sökning: WFRF:(Salvatore Jessica E.) > Social genetic effe...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04699naa a2200409 4500 | |
| 001 | oai:lup.lub.lu.se:d995f1bf-3479-451f-94ea-5fe7630f020d | |
| 003 | SwePub | |
| 008 | 230210s2023 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/d995f1bf-3479-451f-94ea-5fe7630f020d2 URI |
| 024 | 7 | a https://doi.org/10.1111/add.161082 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Salvatore, Jessica E.u Rutgers Robert Wood Johnson Medical School4 aut |
| 245 | 1 0 | a Social genetic effects for drug use disorder among spouses |
| 264 | c 2022-12-27 | |
| 264 | 1 | b Wiley,c 2023 |
| 520 | a Aims: Preclinical and human studies suggest that a social partner's genotype may be associated with addiction-related outcomes. This study measured whether spousal genetic makeup is associated with risk of developing drug use disorder (DUD) during marriage and whether the risk associated with a spouse's genotype could be disentangled from potentially confounding rearing environmental effects. Design: Univariable and multivariable logistic regression analyses. Setting: Sweden. Participants: Men and women born between 1960 and 1990 and in opposite-sex first marriages before age 35 (n = 294 748 couples). Measurements: Outcome was DUD diagnosis (inclusive of opioids, sedatives/hypnotics/anxiolytics, cocaine, cannabis, amphetamine and other psychostimulants, hallucinogens, other drugs of abuse and combinations thereof) obtained from legal, medical and pharmacy registries. The focal predictor was family genetic risk scores for DUD (FGRS-DUD), which were inferred from diagnoses in first- through fifth-degree relatives and weighted by degree of genetic sharing. FGRS-DUD were calculated separately for each partner in a couple. Findings: Marriage to a spouse with a high FGRS-DUD was associated with increased risk of developing DUD during marriage, ORmales = 1.68 (95% CI = 1.50, 1.88) and ORfemales = 1.35 (1.16, 1.56), above and beyond the risk associated with one's own FGRS-DUD. The risk associated with a spouse's FGRS-DUD remained statistically significant after covarying for parental education. As indicated by a series of null interaction effects, there was no evidence that the risk associated with a spouse's FGRS-DUD differed depending on whether the spouse was DUD-affected, probands' probable contact with in-laws and whether the spouse was raised by his/her biological parents or in another home. Conclusions: There is relatively robust evidence that a person's risk for developing drug use disorder is associated with the genetic makeup of the person's spouse. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
| 653 | a Drug use disorder | |
| 653 | a family genetic risk score | |
| 653 | a marriage | |
| 653 | a metagenomics | |
| 653 | a social genetic effects | |
| 653 | a social transmission | |
| 700 | 1 | a Larsson Lönn, Sarau Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Center for Primary Health Care Research4 aut0 (Swepub:lu)mats-sla |
| 700 | 1 | a Sundquist, Janu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Family Medicine and Clinical Epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Center for Primary Health Care Research4 aut0 (Swepub:lu)med-jsu |
| 700 | 1 | a Kendler, Kenneth S.u Virginia Commonwealth University4 aut |
| 700 | 1 | a Sundquist, Kristinau Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Family Medicine and Clinical Epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Center for Primary Health Care Research4 aut0 (Swepub:lu)med-ksq |
| 710 | 2 | a Rutgers Robert Wood Johnson Medical Schoolb Allmänmedicin och klinisk epidemiologi4 org |
| 773 | 0 | t Addictiond : Wileyg 118:5, s. 880-889q 118:5<880-889x 0965-2140x 1360-0443 |
| 856 | 4 | u http://dx.doi.org/10.1111/add.16108y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/d995f1bf-3479-451f-94ea-5fe7630f020d |
| 856 | 4 8 | u https://doi.org/10.1111/add.16108 |
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