Sökning: WFRF:(Svensson Jenny) > Increase in Acid To...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04018naa a2200445 4500 | |
001 | oai:DiVA.org:lnu-7087 | |
003 | SwePub | |
008 | 100810s2010 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-134586 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-70872 URI |
024 | 7 | a https://doi.org/10.1128/AEM.01219-092 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1345862 URI |
040 | a (SwePub)lnud (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Axelsson Olsson, Dianau Linnéuniversitetet,Institutionen för naturvetenskap, NV4 aut0 (Swepub:lnu)eaxdi |
245 | 1 0 | a Increase in Acid Tolerance of Campylobacter jejuni through Coincubation with Amoebae |
264 | 1 | c 2010 |
338 | a print2 rdacarrier | |
520 | a Campylobacter jejuni is a recognized and common gastrointestinal pathogen in most parts of the world. Human infections are often food borne, and the bacterium is frequent among poultry and other food animals. However, much less is known about the epidemiology of C. jejuni in the environment and what mechanisms the bacterium depends on to tolerate low pH. The sensitive nature of C. jejuni stands in contrast to the fact that it is difficult to eradicate from poultry production, and even more contradictory is the fact that the bacterium is able to survive the acidic passage through the human stomach. Here we expand the knowledge on C. jejuni acid tolerance by looking at protozoa as a potential epidemiological pathway of infection. Our results showed that when C. jejuni cells were coincubated with Acanthamoeba polyphaga in acidified phosphate-buffered saline (PBS) or tap water, the bacteria could tolerate pHs far below those in their normal range, even surviving at pH 4 for 20 h and at pH 2 for 5 h. Interestingly, moderately acidic conditions (pH 4 and 5) were shown to trigger C. jejuni motility as well as to increase adhesion/internalization of bacteria into A. polyphaga. Taken together, the results suggest that protozoa may act as protective hosts against harsh conditions and might be a potential risk factor for C. jejuni infections. These findings may be important for our understanding of C. jejuni passage through the gastrointestinal tract and for hygiene practices used in poultry settings. | |
650 | 7 | a NATURVETENSKAPx Biologix Mikrobiologi0 (SwePub)106062 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Microbiology0 (SwePub)106062 hsv//eng |
653 | a Microbiology | |
653 | a Mikrobiologi | |
653 | a Mikrobiologi | |
653 | a Microbiology | |
653 | a MEDICINE | |
700 | 1 | a Svensson, Lovisau Uppsala universitet,Linnéuniversitetet,Institutionen för naturvetenskap, NV,Institutionen för medicinska vetenskaper,infektionssjukdomar4 aut0 (Swepub:lnu)jsvlo |
700 | 1 | a Olofsson, Jennyu Uppsala universitet,Linnéuniversitetet,Institutionen för naturvetenskap, NV,Infektionssjukdomar4 aut0 (Swepub:uu)jenol508 |
700 | 1 | a Salomon, Paulou Linnéuniversitetet,Institutionen för naturvetenskap, NV4 aut0 (Swepub:lnu)nsapa |
700 | 1 | a Waldenström, Jonas,d 1975-u Uppsala universitet,Linnéuniversitetet,Institutionen för naturvetenskap, NV,Infektionssjukdomar,infektionssjukdomar4 aut0 (Swepub:lnu)ewajo |
700 | 1 | a Ellström, Patriku Uppsala universitet,Klinisk bakteriologi,klinisk bakteriologi4 aut0 (Swepub:uu)patel687 |
700 | 1 | a Olsen, Björnu Uppsala universitet,Linnéuniversitetet,Institutionen för naturvetenskap, NV,Infektionssjukdomar,infektionssjukdomar4 aut0 (Swepub:uu)bjool781 |
710 | 2 | a Linnéuniversitetetb Institutionen för naturvetenskap, NV4 org |
773 | 0 | t Applied and Environmental Microbiologyg 76:13, s. 4194-4200q 76:13<4194-4200x 0099-2240x 1098-5336 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-7087 |
856 | 4 8 | u https://doi.org/10.1128/AEM.01219-09 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-134586 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.