Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia

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Fältnamn	Indikatorer	Metadata
000		07617naa a2201861 4500
001		oai:DiVA.org:uu-207028
003		SwePub
008		130909s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:127126091
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2070282 URI
024	7	a https://doi.org/10.1038/ng.26522 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1271260912 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Berndt, Sonja I.4 aut
245	1 0	a Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia
264		c 2013-06-16
264	1	b Springer Science and Business Media LLC,c 2013
338		a print2 rdacarrier
520		a Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P = 1.22 x 10(-14)), 18q21.33 (BCL2, P = 7.76 x 10(-11)), 11p15.5 (C11orf21, P = 2.15 x 10(-10)), 4q25 (LEF1, P = 4.24 x 10(-10)), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P = 2.50 x 10(-9)), 9p21.3 (CDKN2B-AS1, P = 1.27 x 10(-8)), 18q21.32 (PMAIP1, P = 2.51 x 10(-8)), 15q15.1 (BMF, P = 2.71 x 10(-10)) and 2p22.2 (QPCT, P = 1.68 x 10(-8)), as well as an independent signal at an established locus (2q13, ACOXL, P = 2.08 x 10(-18)). We also found evidence for two additional promising loci below genome-wide significance at 8q22.3 (ODF1, P = 5.40 x 10(-8)) and 5p15.33 (TERT, P = 1.92 x 10(-7)). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism.
700	1	a Skibola, Christine F.4 aut
700	1	a Joseph, Vijai4 aut
700	1	a Camp, Nicola J.4 aut
700	1	a Nieters, Alexandra4 aut
700	1	a Wang, Zhaoming4 aut
700	1	a Cozen, Wendy4 aut
700	1	a Monnereau, Alain4 aut
700	1	a Wang, Sophia S.4 aut
700	1	a Kelly, Rachel S.4 aut
700	1	a Lan, Qing4 aut
700	1	a Teras, Lauren R.4 aut
700	1	a Chatterjee, Nilanjan4 aut
700	1	a Chung, Charles C.4 aut
700	1	a Yeager, Meredith4 aut
700	1	a Brooks-Wilson, Angela R.4 aut
700	1	a Hartge, Patricia4 aut
700	1	a Purdue, Mark P.4 aut
700	1	a Birmann, Brenda M.4 aut
700	1	a Armstrong, Bruce K.4 aut
700	1	a Cocco, Pierluigi4 aut
700	1	a Zhang, Yawei4 aut
700	1	a Severi, Gianluca4 aut
700	1	a Zeleniuch-Jacquotte, Anne4 aut
700	1	a Lawrence, Charles4 aut
700	1	a Burdette, Laurie4 aut
700	1	a Yuenger, Jeffrey4 aut
700	1	a Hutchinson, Amy4 aut
700	1	a Jacobs, Kevin B.4 aut
700	1	a Call, Timothy G.4 aut
700	1	a Shanafelt, Tait D.4 aut
700	1	a Novak, Anne J.4 aut
700	1	a Kay, Neil E.4 aut
700	1	a Liebow, Mark4 aut
700	1	a Wang, Alice H.4 aut
700	1	a Smedby, Karin E.u Karolinska Institutet4 aut
700	1	a Adami, Hans-Olovu Karolinska Institutet4 aut
700	1	a Melbye, Mads4 aut
700	1	a Glimelius, Bengtu Uppsala universitet,Enheten för onkologi4 aut0 (Swepub:uu)bengglim
700	1	a Chang, Ellen T.4 aut
700	1	a Glenn, Martha4 aut
700	1	a Curtin, Karen4 aut
700	1	a Cannon-Albright, Lisa A.4 aut
700	1	a Jones, Brandt4 aut
700	1	a Diver, W. Ryan4 aut
700	1	a Link, Brian K.4 aut
700	1	a Weiner, George J.4 aut
700	1	a Conde, Lucia4 aut
700	1	a Bracci, Paige M.4 aut
700	1	a Riby, Jacques4 aut
700	1	a Holly, Elizabeth A.4 aut
700	1	a Smith, Martyn T.4 aut
700	1	a Jackson, Rebecca D.4 aut
700	1	a Tinker, Lesley F.4 aut
700	1	a Benavente, Yolanda4 aut
700	1	a Becker, Nikolaus4 aut
700	1	a Boffetta, Paolo4 aut
700	1	a Brennan, Paul4 aut
700	1	a Foretova, Lenka4 aut
700	1	a Maynadie, Marc4 aut
700	1	a McKay, James4 aut
700	1	a Staines, Anthony4 aut
700	1	a Rabe, Kari G.4 aut
700	1	a Achenbach, Sara J.4 aut
700	1	a Vachon, Celine M.4 aut
700	1	a Goldin, Lynn R.4 aut
700	1	a Strom, Sara S.4 aut
700	1	a Lanasa, Mark C.4 aut
700	1	a Spector, Logan G.4 aut
700	1	a Leis, Jose F.4 aut
700	1	a Cunningham, Julie M.4 aut
700	1	a Weinberg, J. Brice4 aut
700	1	a Morrison, Vicki A.4 aut
700	1	a Caporaso, Neil E.4 aut
700	1	a Norman, Aaron D.4 aut
700	1	a Linet, Martha S.4 aut
700	1	a De Roos, Anneclaire J.4 aut
700	1	a Morton, Lindsay M.4 aut
700	1	a Severson, Richard K.4 aut
700	1	a Riboli, Elio4 aut
700	1	a Vineis, Paolo4 aut
700	1	a Kaaks, Rudolph4 aut
700	1	a Trichopoulos, Dimitrios4 aut
700	1	a Masala, Giovanna4 aut
700	1	a Weiderpass, Elisabeteu Karolinska Institutet4 aut
700	1	a Chirlaque, Mara-Dolores4 aut
700	1	a Vermeulen, Roel C. H.4 aut
700	1	a Travis, Ruth C.4 aut
700	1	a Giles, Graham G.4 aut
700	1	a Albanes, Demetrius4 aut
700	1	a Virtamo, Jarmo4 aut
700	1	a Weinstein, Stephanie4 aut
700	1	a Clavel, Jacqueline4 aut
700	1	a Zheng, Tongzhang4 aut
700	1	a Holford, Theodore R.4 aut
700	1	a Offit, Kenneth4 aut
700	1	a Zelenetz, Andrew4 aut
700	1	a Klein, Robert J.4 aut
700	1	a Spinelli, John J.4 aut
700	1	a Bertrand, Kimberly A.4 aut
700	1	a Laden, Francine4 aut
700	1	a Giovannucci, Edward4 aut
700	1	a Kraft, Peter4 aut
700	1	a Kricker, Anne4 aut
700	1	a Turner, Jenny4 aut
700	1	a Vajdic, Claire M.4 aut
700	1	a Ennas, Maria Grazia4 aut
700	1	a Ferri, Giovanni M.4 aut
700	1	a Miligi, Lucia4 aut
700	1	a Liang, Liming4 aut
700	1	a Sampson, Joshua4 aut
700	1	a Crouch, Simon4 aut
700	1	a Park, Ju-Hyun4 aut
700	1	a North, Kari E.4 aut
700	1	a Cox, Angela4 aut
700	1	a Snowden, John A.4 aut
700	1	a Wright, Josh4 aut
700	1	a Carracedo, Angel4 aut
700	1	a Lopez-Otin, Carlos4 aut
700	1	a Bea, Silvia4 aut
700	1	a Salaverria, Itziar4 aut
700	1	a Martin-Garcia, David4 aut
700	1	a Campo, Elias4 aut
700	1	a Fraumeni, Joseph F., Jr.4 aut
700	1	a de Sanjose, Silvia4 aut
700	1	a Hjalgrim, Henrik4 aut
700	1	a Cerhan, James R.4 aut
700	1	a Chanock, Stephen J.4 aut
700	1	a Rothman, Nathaniel4 aut
700	1	a Slager, Susan L.4 aut
710	2	a Karolinska Institutetb Enheten för onkologi4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 45:8, s. 868-U202q 45:8<868-U202x 1061-4036x 1546-1718
856	4	u https://europepmc.org/articles/pmc3729927?pdf=render
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-207028
856	4 8	u https://doi.org/10.1038/ng.2652
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:127126091

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Av författaren/redakt...: Berndt, Sonja I.; Skibola, Christi ...; Joseph, Vijai; Camp, Nicola J.; Nieters, Alexand ...; Wang, Zhaoming; visa fler...; Cozen, Wendy; Monnereau, Alain; Wang, Sophia S.; Kelly, Rachel S.; Lan, Qing; Teras, Lauren R.; Chatterjee, Nila ...; Chung, Charles C ...; Yeager, Meredith; Brooks-Wilson, A ...; Hartge, Patricia; Purdue, Mark P.; Birmann, Brenda ...; Armstrong, Bruce ...; Cocco, Pierluigi; Zhang, Yawei; Severi, Gianluca; Zeleniuch-Jacquo ...; Lawrence, Charle ...; Burdette, Laurie; Yuenger, Jeffrey; Hutchinson, Amy; Jacobs, Kevin B.; Call, Timothy G.; Shanafelt, Tait ...; Novak, Anne J.; Kay, Neil E.; Liebow, Mark; Wang, Alice H.; Smedby, Karin E.; Adami, Hans-Olov; Melbye, Mads; Glimelius, Bengt; Chang, Ellen T.; Glenn, Martha; Curtin, Karen; Cannon-Albright, ...; Jones, Brandt; Diver, W. Ryan; Link, Brian K.; Weiner, George J ...; Conde, Lucia; Bracci, Paige M.; Riby, Jacques; Holly, Elizabeth ...; Smith, Martyn T.; Jackson, Rebecca ...; Tinker, Lesley F ...; Benavente, Yolan ...; Becker, Nikolaus; Boffetta, Paolo; Brennan, Paul; Foretova, Lenka; Maynadie, Marc; McKay, James; Staines, Anthony; Rabe, Kari G.; Achenbach, Sara ...; Vachon, Celine M ...; Goldin, Lynn R.; Strom, Sara S.; Lanasa, Mark C.; Spector, Logan G ...; Leis, Jose F.; Cunningham, Juli ...; Weinberg, J. Bri ...; Morrison, Vicki ...; Caporaso, Neil E ...; Norman, Aaron D.; Linet, Martha S.; De Roos, Annecla ...; Morton, Lindsay ...; Severson, Richar ...; Riboli, Elio; Vineis, Paolo; Kaaks, Rudolph; Trichopoulos, Di ...; Masala, Giovanna; Weiderpass, Elis ...; Chirlaque, Mara- ...; Vermeulen, Roel ...; Travis, Ruth C.; Giles, Graham G.; Albanes, Demetri ...; Virtamo, Jarmo; Weinstein, Steph ...; Clavel, Jacqueli ...; Zheng, Tongzhang; Holford, Theodor ...; Offit, Kenneth; Zelenetz, Andrew; Klein, Robert J.; Spinelli, John J ...; Bertrand, Kimber ...; Laden, Francine; Giovannucci, Edw ...; Kraft, Peter; Kricker, Anne; Turner, Jenny; Vajdic, Claire M ...; Ennas, Maria Gra ...; Ferri, Giovanni ...; Miligi, Lucia; Liang, Liming; Sampson, Joshua; Crouch, Simon; Park, Ju-Hyun; North, Kari E.; Cox, Angela; Snowden, John A.; Wright, Josh; Carracedo, Angel; Lopez-Otin, Carl ...; Bea, Silvia; Salaverria, Itzi ...; Martin-Garcia, D ...; Campo, Elias; Fraumeni, Joseph ...; de Sanjose, Silv ...; Hjalgrim, Henrik; Cerhan, James R.; Chanock, Stephen ...; Rothman, Nathani ...; Slager, Susan L.; visa färre...

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