Interethnic analyses of blood pressure loci in populations of East Asian and European descent

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Fältnamn	Indikatorer	Metadata
000		06403naa a2201465 4500
001		oai:DiVA.org:umu-177962
003		SwePub
008		201228s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1779622 URI
024	7	a https://doi.org/10.1038/s41467-018-07345-02 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Takeuchi, Fumihiko4 aut
245	1 0	a Interethnic analyses of blood pressure loci in populations of East Asian and European descent
264		c 2018-11-28
264	1	b Springer Nature,c 2018
338		a electronic2 rdacarrier
520		a Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Akiyama, Masato4 aut
700	1	a Matoba, Nana4 aut
700	1	a Katsuya, Tomohiro4 aut
700	1	a Nakatochi, Masahiro4 aut
700	1	a Tabara, Yasuharu4 aut
700	1	a Narita, Akira4 aut
700	1	a Saw, Woei-Yuh4 aut
700	1	a Moon, Sanghoon4 aut
700	1	a Spracklen, Cassandra N.4 aut
700	1	a Chai, Jin-Fang4 aut
700	1	a Kim, Young-Jin4 aut
700	1	a Zhang, Liang4 aut
700	1	a Wang, Chaolong4 aut
700	1	a Li, Huaixing4 aut
700	1	a Li, Honglan4 aut
700	1	a Wu, Jer-Yuarn4 aut
700	1	a Dorajoo, Rajkumar4 aut
700	1	a Nierenberg, Jovia L.4 aut
700	1	a Wang, Ya Xing4 aut
700	1	a He, Jing4 aut
700	1	a Bennett, Derrick A.4 aut
700	1	a Takahashi, Atsushi4 aut
700	1	a Momozawa, Yukihide4 aut
700	1	a Hirata, Makoto4 aut
700	1	a Matsuda, Koichi4 aut
700	1	a Rakugi, Hiromi4 aut
700	1	a Nakashima, Eitaro4 aut
700	1	a Isono, Masato4 aut
700	1	a Shirota, Matsuyuki4 aut
700	1	a Hozawa, Atsushi4 aut
700	1	a Ichihara, Sahoko4 aut
700	1	a Matsubara, Tatsuaki4 aut
700	1	a Yamamoto, Ken4 aut
700	1	a Kohara, Katsuhiko4 aut
700	1	a Igase, Michiya4 aut
700	1	a Han, Sohee4 aut
700	1	a Gordon-Larsen, Penny4 aut
700	1	a Huang, Wei4 aut
700	1	a Lee, Nanette R.4 aut
700	1	a Adair, Linda S.4 aut
700	1	a Hwang, Mi Yeong4 aut
700	1	a Lee, Juyoung4 aut
700	1	a Chee, Miao Li4 aut
700	1	a Sabanayagam, Charumathi4 aut
700	1	a Zhao, Wanting4 aut
700	1	a Liu, Jianjun4 aut
700	1	a Reilly, Dermot F.4 aut
700	1	a Sun, Liang4 aut
700	1	a Huo, Shaofeng4 aut
700	1	a Edwards, Todd L.4 aut
700	1	a Long, Jirong4 aut
700	1	a Chang, Li-Ching4 aut
700	1	a Chen, Chien-Hsiun4 aut
700	1	a Yuan, Jian-Min4 aut
700	1	a Koh, Woon-Puay4 aut
700	1	a Friedlander, Yechiel4 aut
700	1	a Kelly, Tanika N.4 aut
700	1	a Bin Wei, Wen4 aut
700	1	a Xu, Liang4 aut
700	1	a Cai, Hui4 aut
700	1	a Xiang, Yong-Bing4 aut
700	1	a Lin, Kuang4 aut
700	1	a Clarke, Robert4 aut
700	1	a Walters, Robin G.4 aut
700	1	a Millwood, Iona Y.4 aut
700	1	a Li, Liming4 aut
700	1	a Chambers, John C.4 aut
700	1	a Kooner, Jaspal S.4 aut
700	1	a Elliott, Paul4 aut
700	1	a van der Harst, Pim4 aut
700	1	a Chen, Zhengming4 aut
700	1	a Sasaki, Makoto4 aut
700	1	a Shu, Xiao-Ou4 aut
700	1	a Jonas, Jost B.4 aut
700	1	a He, Jiang4 aut
700	1	a Heng, Chew-Kiat4 aut
700	1	a Chen, Yuan-Tsong4 aut
700	1	a Zheng, Wei4 aut
700	1	a Lin, Xu4 aut
700	1	a Teo, Yik-Ying4 aut
700	1	a Tai, E-Shyong4 aut
700	1	a Cheng, Ching-Yu4 aut
700	1	a Wong, Tien Yin4 aut
700	1	a Sim, Xueling4 aut
700	1	a Mohlke, Karen L.4 aut
700	1	a Yamamoto, Masayuki4 aut
700	1	a Kim, Bong-Jo4 aut
700	1	a Miki, Tetsuro4 aut
700	1	a Nabika, Toru4 aut
700	1	a Yokota, Mitsuhiro4 aut
700	1	a Kamatani, Yoichiro4 aut
700	1	a Kubo, Michiaki4 aut
700	1	a Kato, Norihiro4 aut
700	1	a Rolandsson, Olovu Umeå universitet,Allmänmedicin,The International Genomics of Blood Pressure (iGEN-BP) Consortium4 ctb0 (Swepub:umu)olro0005
700	1	a Franks, Paul W.u Umeå universitet,Allmänmedicin,The International Genomics of Blood Pressure (iGEN-BP) Consortium; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital, Malmö, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, USA4 ctb0 (Swepub:umu)pafr0003
710	2	a Umeå universitetb Allmänmedicin4 org
773	0	t Nature Communicationsd : Springer Natureg 9:1q 9:1x 2041-1723
856	4	u https://doi.org/10.1038/s41467-018-07345-0y Fulltext
856	4	u https://umu.diva-portal.org/smash/get/diva2:1512676/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://www.nature.com/articles/s41467-018-07345-0.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-177962
856	4 8	u https://doi.org/10.1038/s41467-018-07345-0

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Av författaren/redakt...: Takeuchi, Fumihi ...; Akiyama, Masato; Matoba, Nana; Katsuya, Tomohir ...; Nakatochi, Masah ...; Tabara, Yasuharu; visa fler...; Narita, Akira; Saw, Woei-Yuh; Moon, Sanghoon; Spracklen, Cassa ...; Chai, Jin-Fang; Kim, Young-Jin; Zhang, Liang; Wang, Chaolong; Li, Huaixing; Li, Honglan; Wu, Jer-Yuarn; Dorajoo, Rajkuma ...; Nierenberg, Jovi ...; Wang, Ya Xing; He, Jing; Bennett, Derrick ...; Takahashi, Atsus ...; Momozawa, Yukihi ...; Hirata, Makoto; Matsuda, Koichi; Rakugi, Hiromi; Nakashima, Eitar ...; Isono, Masato; Shirota, Matsuyu ...; Hozawa, Atsushi; Ichihara, Sahoko; Matsubara, Tatsu ...; Yamamoto, Ken; Kohara, Katsuhik ...; Igase, Michiya; Han, Sohee; Gordon-Larsen, P ...; Huang, Wei; Lee, Nanette R.; Adair, Linda S.; Hwang, Mi Yeong; Lee, Juyoung; Chee, Miao Li; Sabanayagam, Cha ...; Zhao, Wanting; Liu, Jianjun; Reilly, Dermot F ...; Sun, Liang; Huo, Shaofeng; Edwards, Todd L.; Long, Jirong; Chang, Li-Ching; Chen, Chien-Hsiu ...; Yuan, Jian-Min; Koh, Woon-Puay; Friedlander, Yec ...; Kelly, Tanika N.; Bin Wei, Wen; Xu, Liang; Cai, Hui; Xiang, Yong-Bing; Lin, Kuang; Clarke, Robert; Walters, Robin G ...; Millwood, Iona Y ...; Li, Liming; Chambers, John C ...; Kooner, Jaspal S ...; Elliott, Paul; van der Harst, P ...; Chen, Zhengming; Sasaki, Makoto; Shu, Xiao-Ou; Jonas, Jost B.; He, Jiang; Heng, Chew-Kiat; Chen, Yuan-Tsong; Zheng, Wei; Lin, Xu; Teo, Yik-Ying; Tai, E-Shyong; Cheng, Ching-Yu; Wong, Tien Yin; Sim, Xueling; Mohlke, Karen L.; Yamamoto, Masayu ...; Kim, Bong-Jo; Miki, Tetsuro; Nabika, Toru; Yokota, Mitsuhir ...; Kamatani, Yoichi ...; Kubo, Michiaki; Kato, Norihiro; Rolandsson, Olov; Franks, Paul W.; visa färre...

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