In situ microdialysis in tendon tissue: high levels of glutamate, but not prostaglandin E2 in chronic Achilles tendon pain

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Fältnamn	Indikatorer	Metadata
000		02958naa a2200361 4500
001		oai:DiVA.org:umu-35344
003		SwePub
008		100813s1999 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-353442 URI
024	7	a https://doi.org/10.1007/s0016700501842 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Alfredson, Håkanu Umeå universitet,Idrottsmedicin4 aut0 (Swepub:umu)haal0002
245	1 0	a In situ microdialysis in tendon tissue :b high levels of glutamate, but not prostaglandin E2 in chronic Achilles tendon pain
264	1	b Springer Science and Business Media LLC,c 1999
338		a print2 rdacarrier
520		a This investigation was to our knowledge the first to use the microdialysis technique to study concentrations of substances in a human tendon. In four patients (mean age 40.7 years) with a painful nodule in the Achilles tendon (chronic Achilles tendinosis) and in five controls (mean age 37.2 years) with normal Achilles tendons (confirmed by ultrasonography) the local concentrations of glutamate and prostaglandin E2 were measured under resting conditions. A standard microdialysis catheter was inserted into the Achilles tendon under local anesthesia. Sampling was performed every 15 min over a 4-h period. The results showed significantly higher concentrations of glutamate in tendons with tendinosis than in normal tendons (196 +/- 59 vs. 48 +/- 27 mumol/l, P < 0.05), and there were no significant changes in glutamate concentration over the period of investigation. There were no significant differences in the mean concentrations of prostaglandin E2 (83 +/- 22 vs. 54 +/- 24 pg/ml) between tendons with tendinosis and normal tendons. In conclusion, in situ microdialysis appears a useful method to study certain metabolic events in tendon tissue. The higher concentrations of the excitatory neurotransmitter glutamate in Achilles tendons with a painful nodule may possibly be involved in the pain mechanism in this chronic condition. Furthermore, there were no signs of inflammation in the tendons with painful nodules, as indicated by the normal prostaglandin E2 levels.
653		a Achilles tendon
653		a Chronic pain
653		a Microdialysis
653		a Glutamate
653		a Prostaglandin E2
653		a MEDICINE
653		a MEDICIN
700	1	a Thorsen, Kimu Umeå universitet,Idrottsmedicin4 aut
700	1	a Lorentzon, Ronnyu Umeå universitet,Idrottsmedicin4 aut0 (Swepub:umu)rolo0001
710	2	a Umeå universitetb Idrottsmedicin4 org
773	0	t Knee Surgery, Sports Traumatology, Arthroscopyd : Springer Science and Business Media LLCg 7:6, s. 378-381q 7:6<378-381x 0942-2056x 1433-7347
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-35344
856	4 8	u https://doi.org/10.1007/s001670050184

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Av författaren/redakt...: Alfredson, Håkan; Thorsen, Kim; Lorentzon, Ronny

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Av lärosätet: Umeå universitet

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