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Sökning: onr:"swepub:oai:DiVA.org:uu-346369" > Reproducible diagno...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006322naa a2200781 4500
001oai:DiVA.org:uu-346369
003SwePub
008180316s2018 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:137514950
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3463692 URI
0247 a https://doi.org/10.1002/cyto.b.215952 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1375149502 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Rawstron, Andy C.u St Jamess Inst Oncol, Leeds4 aut
2451 0a Reproducible diagnosis of chronic lymphocytic leukemia by flow cytometry :b An European Research Initiative on CLL (ERIC) & European Society for Clinical Cell Analysis (ESCCA) Harmonisation project
264 c 2018-01-17
264 1b Wiley,c 2018
338 a electronic2 rdacarrier
520 a The diagnostic criteria for CLL rely on morphology and immunophenotype. Current approaches have limitations affecting reproducibility and there is no consensus on the role of new markers. The aim of this project was to identify reproducible criteria and consensus on markers recommended for the diagnosis of CLL. ERIC/ESCCA members classified 14 of 35 potential markers as “required” or “recommended” for CLL diagnosis, consensus being defined as >75% and >50% agreement, respectively. An approach to validate “required” markers using normal peripheral blood was developed. Responses were received from 150 participants with a diagnostic workload >20 CLL cases per week in 23/150 (15%), 5–20 in 82/150 (55%), and <5 cases per week in 45/150 (30%). The consensus for “required” diagnostic markers included: CD19, CD5, CD20, CD23, Kappa, and Lambda. “Recommended” markers potentially useful for differential diagnosis were: CD43, CD79b, CD81, CD200, CD10, and ROR1. Reproducible criteria for component reagents were assessed retrospectively in 14,643 cases from 13 different centers and showed >97% concordance with current approaches. A pilot study to validate staining quality was completed in 11 centers. Markers considered as “required” for the diagnosis of CLL by the participants in this study (CD19, CD5, CD20, CD23, Kappa, and Lambda) are consistent with current diagnostic criteria and practice. Importantly, a reproducible approach to validate and apply these markers in individual laboratories has been identified. Finally, a consensus “recommended” panel of markers to refine diagnosis in borderline cases (CD43, CD79b, CD81, CD200, CD10, and ROR1) has been defined and will be prospectively evaluated.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng
653 a chronic lymphocytic leukemia
653 a flow cytometry
653 a diagnosis
7001 a Kreuzer, Karl-Antonu Universitätsklinikum Köln, Köln4 aut
7001 a Soosapilla, Ashau Laverty Pathol, Sydney4 aut
7001 a Spacek, Martinu Univ Hosp, Prague4 aut
7001 a Stehlikova, Olgau Masaryk Univ, CEITEC, Brno; Univ Hosp Brno, Dept Internal Med Hematol & Oncol, Brno4 aut
7001 a Gambell, Peteru Peter MacCallum Canc Ctr, Melbourne4 aut
7001 a McIver-Brown, Neilu Royal Bournemouth Hosp, Bournemouth4 aut
7001 a Villamor, Neusu Hosp Clin Barcelona, Hematopathol Unit, Barcelona4 aut
7001 a Psarra, Katherinau Evangelismos Med Ctr, Athens4 aut
7001 a Arroz, Mariau CHLO Hosp S Francisco Xavier, Dept Clin Pathol, Flow Cytometry Lab, Lisbon4 aut
7001 a Milani, Raffaellau Osped San Raffaele, Milan4 aut
7001 a de la Serna, Javieru Hosp Univ 12 Octubre, Madrid4 aut
7001 a Teresa Cedena, M.u Hosp Univ 12 Octubre, Madrid4 aut
7001 a Jaksic, Ozrenu Dubrava Univ Hosp, Zagreb4 aut
7001 a Nomdedeu, Josepu Hosp Santa Creu & Sant Pau, Barcelona4 aut
7001 a Moreno, Carolu Hosp Santa Creu & Sant Pau, Barcelona4 aut
7001 a Rigolin, Gian Matteou St Anna Univ Hosp, Ferrara4 aut
7001 a Cuneo, Antoniou St Anna Univ Hosp, Ferrara4 aut
7001 a Johansen, Prebenu Aalborg Univ Hosp, Dept Haematol, Clin Canc Res Ctr, Aalborg; Aalborg Univ, Dept Clin Med, Aalborg4 aut
7001 a Johnsen, Hans E.u Aalborg Univ Hosp, Dept Haematol, Clin Canc Res Ctr, Aalborg; Aalborg Univ, Dept Clin Med, Aalborg4 aut
7001 a Rosenquist, Richardu Karolinska Institutet,Uppsala universitet,Experimentell och klinisk onkologi4 aut0 (Swepub:uu)richrose
7001 a Niemann, Carsten Utoftu Copenhagen Univ Hosp, Rigshosp, Copenhagen4 aut
7001 a Kern, Wolfgangu MLL Munich Leukemia Lab, Munich4 aut
7001 a Westerman, Davidu Univ Hosp Brno, Dept Internal Med Hematol & Oncol, Brno4 aut
7001 a Trneny, Mareku Univ Hosp, Prague4 aut
7001 a Mulligan, Stephenu Laverty Pathol, Sydney4 aut
7001 a Doubek, Michaelu Masaryk Univ, CEITEC, Brno4 aut
7001 a Pospisilova, Sarkau Masaryk Univ, CEITEC, Brno4 aut
7001 a Hillmen, Peteru St Jamess Inst Oncol, Leeds4 aut
7001 a Oscier, Davidu Royal Bournemouth Hosp, Bournemouth4 aut
7001 a Hallek, Michaelu Univ Klinikum Köln, Köln4 aut
7001 a Ghia, Paolou Univ Vita Salute San Raffaele, Milan; IRCCS Ist Sci San Raffaele, Milan4 aut
7001 a Montserrat, Emiliu Univ Barcelona, Hosp Clin, Dept Hematol, Barcelona4 aut
7102 a St Jamess Inst Oncol, Leedsb Universitätsklinikum Köln, Köln4 org
7730 t Cytometry. Part B, Clinical cytometry.d : Wileyg 94:1, s. 121-128q 94:1<121-128x 1552-4949x 1552-4957
8564 u https://doi.org/10.1002/cyto.b.21595y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1191241/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.b.21595
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-346369
8564 8u https://doi.org/10.1002/cyto.b.21595
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:137514950

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