L773:1873 5169 OR L773:0196 9781
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03022naa a2200481 4500 | |
| 001 | oai:DiVA.org:uu-50735 | |
| 003 | SwePub | |
| 008 | 081017s1998 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-507352 URI |
| 024 | 7 | a https://doi.org/10.1016/S0196-9781(98)00079-52 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Silberring, Jerzy4 aut |
| 245 | 1 0 | a Characterization of immunoreactive dynorphin B and beta-endorphin in human plasma |
| 264 | 1 | c 1998 |
| 338 | a print2 rdacarrier | |
| 520 | a Dynorphins and beta-endorphin in human plasma were characterized and studied quantitatively using radioimmunoassay, high-performance liquid chromatography (HPLC), and mass spectrometry. Most immunoreactive (ir) dynorphin B and beta-endorphin in human plasma coeluted with authentic peptides in analysis. Dynorphin A was not detected. Added to human plasma it was rapidly converted into Leu-enkephalin-Arg6 followed by elimination of the C-terminal arginine after prolonged incubation. The rate of dynorphin A conversion was estimated at 40 pmol/min/microl plasma. This process was inhibited by the thiol protease inhibitor, PHMB and by EDTA. Dynorphin B, alpha-neoendorphin and big dynorphin were virtually not metabolized by plasma proteases under the same conditions. beta-endorphin was processed into beta-endorphin(1-19) and the corresponding C-terminal counterpart beta-endorphin(20-31) at a rate of about 25 pmol/min/microl of plasma. Based on the above data, a reliable strategy was established to measure dynorphin B- and beta-endorphin-ir in human plasma samples. The basal levels in a male control group were 0.99 +/- 0.11 (n = 11) and 16.3 +/- 1.5 (n = 11) fmol/ml plasma, respectively. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng |
| 653 | a dynorphins | |
| 653 | a endorphins | |
| 653 | a neuropeptides | |
| 653 | a metabolism | |
| 653 | a proteases | |
| 653 | a protease inhibitors | |
| 653 | a plasma | |
| 653 | a human | |
| 653 | a high pressure liquid chromatography | |
| 653 | a mass spectrometry | |
| 653 | a PHARMACY | |
| 653 | a FARMACI | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Li, Yi-Ming4 aut |
| 700 | 1 | a Terenius, Lars4 aut |
| 700 | 1 | a Nylander, Ingridu Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Pharmacology4 aut0 (Swepub:uu)iny08577 |
| 710 | 2 | a Uppsala universitetb Institutionen för farmaceutisk biovetenskap4 org |
| 773 | 0 | t Peptidesg 19:8, s. 1329-1337q 19:8<1329-1337x 0196-9781x 1873-5169 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-50735 |
| 856 | 4 8 | u https://doi.org/10.1016/S0196-9781(98)00079-5 |
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