SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Berner Michael)
 

Sökning: WFRF:(Berner Michael) > Diagnostic and prog...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005661nam a2200457 4500
001oai:DiVA.org:liu-153624
003SwePub
008190104s2018 | |||||||||||000 ||eng|
020 a 9789176851456q print
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1536242 URI
0247 a https://doi.org/10.3384/diss.diva-1536242 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a vet2 swepub-contenttype
072 7a dok2 swepub-publicationtype
1001 a Ziegelasch, Michael,d 1966-u Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland4 aut0 (Swepub:liu)miczi38
2451 0a Diagnostic and prognostic potential of joint imaging in patients with anti-citrullinated protein antibodies
264 1a Linköping :b Linköping University Electronic Press,c 2018
300 a 56 s.
338 a electronic2 rdacarrier
4900 a Linköping University Medical Dissertations,x 0345-0082 ;v 1658
520 a The introduction of novel therapeutic strategies set new goals for the patients’ outcome, which aims to achieve remission. This goal requires early diagnosis of RA and prompt efficient pharmacotherapy. The introduction of anti-citrullinated protein antibodies (ACPA) two decades ago allowed an earlier RA diagnosis. However, there are indications that ACPA positivity is still associated with higher rates of radiographic damage. As the small joints in hands and feet commonly are the first involved sites of inflammation, the role of different imaging modalities were studied regarding their diagnostic and prognostic impact for assessment of arthritis in RA. Further, ultrasound (US) and radiography were used to study the association between RA-specific antibodies and the occurrence of arthritis and joint damage in systemic lupus erythematosus (SLE).The use of US allows assessment of soft tissue like joint capsules, tendons and bursae. Used for a live scanning, it is easy to detect effusions and edema. Doppler indicates vasoproliferation were inflammation is present. Also, US seems to be more sensitive than radiography to detect minimal structural changes located at bone surfaces. We wanted to investigate whether US findings in a pre-RA stage can predict development of arthritis.Digital X-ray radiogrammetry (DXR) is a technique based on computerized analyses of standard hand radiographs to calculate peripheral bone mineral density (BMD) of the three middle metacarpal bones (DXR-BMD). In order for early treatment decisions, we aimed to study whether changes in DXR-BMD loss after 3 months can predict radiographic damage in early RA.In conclusion, the studies showed that ACPA-positivity is still associated with a higher risk of radiographic damage regardless of early treatment decisions. Therefore, close radiographic monitoring and readiness to intensive treatment is warranted in ACPA-positive patients. This thesis also shows that erosions detected by US in ACPA-positive patients with arthralgia predict development of clinical arthritis. Also, the magnitude of DXR-BMD loss helps identify patients at higher risk for future radiographic damage, and may therefore help to improve early treatment decisions. Finally, US and radiography confirm a higher rate of arthritis and erosions also in SLE patients who are positive for RA-specific antibodies.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
7001 a Skogh, Thomas,c Professor emeritus,d 1952-u Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland4 ths0 (Swepub:liu)thosk00
7001 a Kastbom, Alf,c Lecturer,d 1978-u Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland4 ths0 (Swepub:liu)alfka05
7001 a Magnusson, Mattias,c Assistant Professor,d 1972-u Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten4 ths0 (Swepub:liu)matma88
7001 a Forslind, Kristina,c Dr.u Helsingborg Hospital, Sweden; Lund University, Sweden4 ths
7001 a Berner-Hammer, Hilde,c Dr.u Deptartment of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway4 ths
7001 a Cedergren, Jan,c Dr.d 1965-u Region Östergötland, Reumatologiska kliniken i Östergötland4 ths0 (Swepub:liu)jance71
7001 a Sokka-Isler, Tuulikki,c Professoru Central Hospital Central Finland, Department of Medicine, Finland4 opn
7102 a Linköpings universitetb Avdelningen för neuro- och inflammationsvetenskap4 org
8564 u https://doi.org/10.3384/diss.diva-153624y Fulltext
8564 u https://liu.diva-portal.org/smash/get/diva2:1275057/FULLTEXT01.pdfx primaryx Raw objecty fulltext
8564 u https://liu.diva-portal.org/smash/get/diva2:1275057/PREVIEW01.pngx Previewy preview image
8564 u http://liu.diva-portal.org/smash/get/diva2:1275057/FULLTEXT01
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-153624
8564 8u https://doi.org/10.3384/diss.diva-153624

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy