Sökning: WFRF:(Brooks James D) > (2020-2024) > Risks of depression...
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000 | 04203naa a2200361 4500 | |
001 | oai:lup.lub.lu.se:b19cc7e9-17a4-4a3e-b4f4-f4b52fad3739 | |
003 | SwePub | |
008 | 240523s2024 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/b19cc7e9-17a4-4a3e-b4f4-f4b52fad37392 URI |
024 | 7 | a https://doi.org/10.1093/jnci/djad2572 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Crump, Caseyu University of Texas4 aut0 (Swepub:lu)med-ccr |
245 | 1 0 | a Risks of depression, anxiety, and suicide in partners of men with prostate cancer : a national cohort study |
264 | 1 | c 2024 |
300 | a 8 s. | |
520 | a Background: A diagnosis of prostate cancer (PC) may cause psychosocial distress not only in a man but also in his intimate partner. However, long-term risks of depression, anxiety, or suicide in partners of men with PC are largely unknown. Methods: A national cohort study was conducted of 121 530 partners of men diagnosed with PC during 1998-2017 and 1 093 304 population-based controls in Sweden. Major depression, anxiety disorder, and suicide death were ascertained through 2018. Cox regression was used to compute hazard ratios (HRs) while adjusting for sociodemographic factors. Results: Partners of men with high-risk PC had increased risks of major depression (adjusted HR ¼ 1.34, 95% confidence interval [CI] ¼ 1.30 to 1.39) and anxiety disorder (adjusted HR ¼ 1.25, 95% CI ¼ 1.20 to 1.30), which remained elevated 10 or more years later. Suicide death was increased in partners of men with distant metastases (adjusted HR ¼ 2.38, 95% CI ¼ 1.08 to 5.22) but not other high-risk PC (adjusted HR ¼1.14, 95% CI ¼ 0.70 to 1.88). Among partners of men with high-risk PC, risks of major depression and anxiety disorder were highest among those 80 years of age or older (adjusted HR ¼ 1.73; 95% CI ¼ 1.53 to 1.96; adjusted HR ¼ 1.70, 95% CI ¼ 1.47 to 1.96, respectively), whereas suicide death was highest among those younger than 60 years of age (adjusted HR ¼ 7.55, 95% CI ¼ 2.20 to 25.89). In contrast, partners of men with low- or intermediate-risk PC had modestly or no increased risks of these outcomes. Conclusions: In this large cohort, partners of men with high-risk PC had increased risks of major depression and anxiety disorder, which persisted for 10 or more years. Suicide death was increased 2-fold in partners of men with distant metastases. Partners as well as men with PC need psychosocial support and close follow-up for psychosocial distress. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
700 | 1 | a Stattin, Paru Uppsala University4 aut |
700 | 1 | a Brooks, James D.u Stanford University School of Medicine4 aut |
700 | 1 | a Sundquist, Janu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Family Medicine and Clinical Epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments4 aut0 (Swepub:lu)med-jsu |
700 | 1 | a Edwards, Alexis C.u Virginia Commonwealth University4 aut |
700 | 1 | a Sundquist, Kristinau Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Family Medicine and Clinical Epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments4 aut0 (Swepub:lu)med-ksq |
700 | 1 | a Sieh, Weivau University of Texas4 aut |
710 | 2 | a Uppsala Universityb University of Texas4 org |
773 | 0 | t Journal of the National Cancer Instituteg 116:5, s. 745-752q 116:5<745-752x 0027-8874 |
856 | 4 | u http://dx.doi.org/10.1093/jnci/djad257y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/b19cc7e9-17a4-4a3e-b4f4-f4b52fad3739 |
856 | 4 8 | u https://doi.org/10.1093/jnci/djad257 |
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