Sökning: WFRF:(Corley Douglas) > Obesity and risk of...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03826naa a2200577 4500 | |
001 | oai:DiVA.org:uu-273748 | |
003 | SwePub | |
008 | 160118s2014 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:130242973 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2737482 URI |
024 | 7 | a https://doi.org/10.1093/jnci/dju2522 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1302429732 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Thrift, Aaron P4 aut |
245 | 1 0 | a Obesity and risk of esophageal adenocarcinoma and Barrett's esophagus :b a Mendelian randomization study. |
264 | c 2014-09-30 | |
264 | 1 | b Oxford University Press (OUP),c 2014 |
338 | a print2 rdacarrier | |
520 | a BACKGROUND: Data from observational studies suggest that body mass index (BMI) is causally related to esophageal adenocarcinoma (EAC) and its precursor, Barrett's esophagus (BE). However, the relationships may be affected by bias and confounding.METHODS: We used data from the Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study: 999 patients with EAC, 2061 patients with BE, and 2169 population controls. We applied the two-stage control function instrumental variable method of the Mendelian randomization approach to estimate the unbiased, unconfounded effect of BMI on risk of EAC and BE. This was performed using a genetic risk score, derived from 29 genetic variants shown to be associated with BMI, as an instrument for lifetime BMI. A higher score indicates propensity to obesity. All tests were two-sided.RESULTS: The genetic risk score was not associated with potential confounders, including gastroesophageal reflux symptoms and smoking. In the instrumental variable analyses (IV), EAC risk increased by 16% (IV-odds ratio [OR] = 1.16, 95% confidence interval [CI] = 1.01 to 1.33) and BE risk increased by 12% (IV-OR = 1.12, 95% CI = 1.00 to 1.25) per 1kg/m(2) increase in BMI. BMI was statistically significantly associated with EAC and BE in conventional epidemiologic analyses.CONCLUSIONS: People with a high genetic propensity to obesity have higher risks of esophageal metaplasia and neoplasia than people with low genetic propensity. These analyses provide the strongest evidence to date that obesity is independently associated with BE and EAC, and is not due to confounding or bias inherent in conventional epidemiologic analyses. | |
700 | 1 | a Shaheen, Nicholas J4 aut |
700 | 1 | a Gammon, Marilie D4 aut |
700 | 1 | a Bernstein, Leslie4 aut |
700 | 1 | a Reid, Brian J4 aut |
700 | 1 | a Onstad, Lynn4 aut |
700 | 1 | a Risch, Harvey A4 aut |
700 | 1 | a Liu, Geoffrey4 aut |
700 | 1 | a Bird, Nigel C4 aut |
700 | 1 | a Wu, Anna H4 aut |
700 | 1 | a Corley, Douglas A4 aut |
700 | 1 | a Romero, Yvonne4 aut |
700 | 1 | a Chanock, Stephen J4 aut |
700 | 1 | a Chow, Wong-Ho4 aut |
700 | 1 | a Casson, Alan G4 aut |
700 | 1 | a Levine, David M4 aut |
700 | 1 | a Zhang, Rui4 aut |
700 | 1 | a Ek, Weronica E4 aut |
700 | 1 | a MacGregor, Stuart4 aut |
700 | 1 | a Ye, Weiminu Karolinska Institutet4 aut |
700 | 1 | a Hardie, Laura J4 aut |
700 | 1 | a Vaughan, Thomas L4 aut |
700 | 1 | a Whiteman, David C4 aut |
710 | 2 | a Karolinska Institutet4 org |
773 | 0 | t Journal of the National Cancer Instituted : Oxford University Press (OUP)g 106:11q 106:11x 0027-8874x 1460-2105 |
856 | 4 | u https://academic.oup.com/jnci/article-pdf/106/11/dju252/17313117/dju252.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-273748 |
856 | 4 8 | u https://doi.org/10.1093/jnci/dju252 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:130242973 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.