Quantitative Structure-Activity Relationship of Peptides Binding to the Class II Major Histocompatibility Complex Molecule A(q) Associated with Autoimmune Arthritis.

Presentation of (glyco)peptides by the class II major histocompatibility complex molecule Aq to T cells plays a central role in collagen-induced arthritis, an animal model for the autoimmune disease rheumatoid arthritis. A peptide library was designed using statistical molecular design in amino acid space in which five positions in the minimal mouse collagen type II binding epitope CII260-267 were varied. A substantially reduced peptide library of 24 peptides with diverse and representative molecular characteristics was selected, synthesized, and evaluated for the binding strength to Aq. A multivariate QSAR model was established by correlating calculated descriptors, compressed to its principle properties, with the binding data using partial least-square regression. The model was successfully validated by an external test set. Interpretation of the model provided a molecular property binding motif for peptides interacting with Aq. The information may be useful in future research directed toward new treatments of rheumatoid arthritis.

Frech, KristinaUmeå universitet,Kemiska institutionen(Swepub:umu)krafrh98 (författare)
Dzhambazov, BalikLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups(Swepub:lu)infl-bdz (författare)
Holmdahl, RikardLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups(Swepub:lu)infl-rho (författare)
Kihlberg, JanUmeå universitet,Kemiska institutionen(Swepub:umu)jaki0001 (författare)
Linusson, AnnaUmeå universitet,Kemiska institutionen(Swepub:umu)analin99 (författare)
Umeå universitetKemiska institutionen (creator_code:org_t)

Ingår i:Journal of Medicinal Chemistry: American Chemical Society (ACS)50:9, s. 2049-20591520-48040022-2623

Av författaren/redakt...: Holm, Lotta; Frech, Kristina; Dzhambazov, Bali ...; Holmdahl, Rikard; Kihlberg, Jan; Linusson, Anna

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Läkemedelskemi

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