Psoriasis susceptibility locus in chromosome region 3q21 identified in patients from southwest Sweden

• We have performed a pair-wise linkage study in the search for psoriasis susceptibility regions. A preliminary scan was performed on 20 families. In this set we obtained indications of linkage on chromosome 3q21. This region was further investigated using material from a total of 104 families (set 1B) resulting in a non-parametric linkage (NPL) of 1.77. The material was stratified in families whose parental origin is in southwest Sweden (set 1C). A maximum NPL value of 2.77 was obtained in this group. A transmission disequilibrium test (TDT) was performed on the stratified material (set 1C) and a significant P value of 0.005 was obtained, at marker D3S1269. The locus was confirmed with TDT in replicate material consisting of 148 families in which a single member was affected (P value 0.0007) at marker D3S1551. Thus, we have observed a significant P value using TDT in the vicinity of markers D3S1269/D3S1551, suggesting a novel psoriasis susceptibility region.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Annan medicin och hälsovetenskap (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Other Medical and Health Sciences (hsv//eng)

Keyword

Chromosome Mapping

Chromosomes

Human

Pair 3/*genetics

Family

Female

Genetic Predisposition to Disease/*genetics

Humans

Linkage (Genetics)

Linkage Disequilibrium/*genetics

Male

Psoriasis/*genetics

Research Support

Non-U.S. Gov't

Sweden

Publication and Content Type

ref (subject category)

art (subject category)