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Novel and establish...
Novel and established anthropometric measures and the prediction of incident cardiovascular disease : a cohort study
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- Carlsson, A. C. (författare)
- Karolinska Institutet
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- Risérus, Ulf (författare)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Engström, Gunnar (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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- Ärnlöv, Johan, 1970- (författare)
- Uppsala universitet,Högskolan Dalarna,Medicinsk vetenskap,Geriatrik
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- Melander, O. (författare)
- Uppsala universitet,Lund University,Lunds universitet,Klinisk nutrition och metabolism
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- Leander, K. (författare)
- Karolinska Institutet
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- Gigante, B. (författare)
- Karolinska Institutet
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- Hellenius, M-L (författare)
- Karolinska Institutet
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- de Faire, U. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2013-03-28
- 2013
- Engelska.
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Ingår i: International Journal of Obesity. - : Springer Science and Business Media LLC. - 0307-0565 .- 1476-5497. ; 37:12, s. 1579-1585
- Relaterad länk:
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https://www.nature.c...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
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- OBJECTIVES: The aim of this study was to compare novel and established anthropometrical measures in their ability to predict cardiovascular disease (CVD), and to determine whether they improve risk prediction beyond classical risk factors in a cohort study of 60-year-old men and women. We also stratified the results according to gender to identify possible differences between men and women. Furthermore, we aimed to replicate our findings in a large independent cohort (The Malmo Diet and Cancer study-cardiovascular cohort).METHODS: This was a population-based study of 1751 men and 1990 women, aged 60 years and without CVD at baseline, with 375 incident cases of CVD during 11 years of follow-up. Weight, height, waist circumference (WC), hip circumference and sagittal abdominal diameter (SAD) were measured at baseline. Body mass index (BMI), waist-hip ratio (WHR), waist-hip-height ratio (WHHR), WC-to-height ratio (WCHR) and SAD-to-height ratio (SADHR) were calculated.RESULTS: All anthropometric measures predicted CVD in unadjusted Cox regression models per s.d. increment (hazard ratios, 95% confidence interval), while significant associations after adjustments for established risk CVD factors were noted for WHHR 1.20 (1.08-1.33), WHR 1.14 (1.02-1.28), SAD 1.13 (1.02-1.25) and SADHR 1.17 (1.06-1.28). WHHR had higher increases in C-statistics, and model improvements (likelihood ratio tests (P<0.001)). In the replication study (MDC-CC, n = 5180), WHHR was the only measure that improved Cox regression models in men (P = 0.01).CONCLUSION: WHHR, a new measure reflecting body fat distribution, showed the highest risk estimates after adjustments for established CVD risk factors. These findings were verified in men but not women in an independent cohort.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- waist circumference
- sagittal abdominal diameter
- waist-hip ratio
- waist-hip-height ratio
- WC-to-height ratio
- SAD-to-height ratio
- Hälsa och välfärd
- Health and Welfare
- waist circumference
- sagittal abdominal diameter
- waist-hip ratio
- waist-hip-height ratio
- WC-to-height ratio
- SAD-to-height ratio
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Carlsson, A. C.
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Risérus, Ulf
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Engström, Gunnar
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Ärnlöv, Johan, 1 ...
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Melander, O.
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Leander, K.
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visa fler...
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Gigante, B.
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Hellenius, M-L
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de Faire, U.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Näringslära
- Artiklar i publikationen
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International Jo ...
- Av lärosätet
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Högskolan Dalarna
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Lunds universitet
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Karolinska Institutet
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Uppsala universitet