Sökning: WFRF:(Epstein L. M.) > (2020-2024) > OTTERS: a powerful ...
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000 | 16670naa a2201369 4500 | |
001 | oai:DiVA.org:ltu-96339 | |
003 | SwePub | |
008 | 230406s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-963392 URI |
024 | 7 | a https://doi.org/10.1038/s41467-023-36862-w2 DOI |
040 | a (SwePub)ltu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Dai, Qileu Department of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA, 30322, USA; Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA4 aut |
245 | 1 0 | a OTTERS: a powerful TWAS framework leveraging summary-level reference data |
264 | 1 | b Springer Nature,c 2023 |
338 | a electronic2 rdacarrier | |
500 | a Godkänd;2023;Nivå 0;2023-04-06 (hanlid);Funder: for more funders see the article https://doi.org/10.1038/s41467-023-36862-w | |
520 | a Most existing TWAS tools require individual-level eQTL reference data and thus are not applicable to summary-level reference eQTL datasets. The development of TWAS methods that can harness summary-level reference data is valuable to enable TWAS in broader settings and enhance power due to increased reference sample size. Thus, we develop a TWAS framework called OTTERS (Omnibus Transcriptome Test using Expression Reference Summary data) that adapts multiple polygenic risk score (PRS) methods to estimate eQTL weights from summary-level eQTL reference data and conducts an omnibus TWAS. We show that OTTERS is a practical and powerful TWAS tool by both simulations and application studies. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
653 | a Medical Engineering | |
653 | a Medicinsk teknik | |
700 | 1 | a Zhou, Geyuu Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06511, USA4 aut |
700 | 1 | a Zhao, Hongyuu Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06511, USA; Department of Biostatistics, Yale School of Public Health, New Haven, CT, 06520, USA4 aut |
700 | 1 | a Võsa, Urmou Estonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia4 aut |
700 | 1 | a Franke, Ludeu Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands; Oncode Institute, 3521 AL, Utrecht, The Netherlands4 aut |
700 | 1 | a Battle, Alexisu Department of Computer Science, and Departments of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA4 aut |
700 | 1 | a Teumer, Alexanderu Institute for Community Medicine, University Medicine Greifswald, 17489, Greifswald, Germany4 aut |
700 | 1 | a Lehtimäki, Terhou Department of Clinical Chemistry, Fimlab Laboratories and Finnish Centre for Cardiovascular Disease Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33520, Finland4 aut |
700 | 1 | a Raitakari, Olli T.u Centre for Population Health Research, University of Turku and Turku University Hospital, 20520, Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, 20520, Turku, Finland; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, 20521, Turku, Finland4 aut |
700 | 1 | a Esko, Tõnuu Estonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia4 aut |
700 | 1 | a Agbessi, Mawusséu Computational Biology, Ontario Institute for Cancer Research, Toronto, ON, Canada4 aut |
700 | 1 | a Ahsan, Habibulu Department of Public Health Sciences, University of Chicago, Chicago, IL, USA4 aut |
700 | 1 | a Alves, Isabelu Computational Biology, Ontario Institute for Cancer Research, Toronto, ON, Canada4 aut |
700 | 1 | a Andiappan, Anand Kumaru Singapore Immunology Network, Agency for Science Technology and Research, Singapore, Singapore4 aut |
700 | 1 | a Arindrarto, Wibowou Leiden University Medical Center, Leiden, The Netherlands4 aut |
700 | 1 | a Awadalla, Philipu Computational Biology, Ontario Institute for Cancer Research, Toronto, ON, Canada4 aut |
700 | 1 | a Battle, Alexisu Institute for Community Medicine, University Medicine Greifswald, 17489, Greifswald, Germany4 aut |
700 | 1 | a Beutner, Franku Heart Center Leipzig, Universität Leipzig, Leipzig, Germany4 aut |
700 | 1 | a Jan Bonder, Marcu Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands; European Molecular Biology Laboratory, Genome Biology Unit, 69117, Heidelberg, Germany4 aut |
700 | 1 | a Boomsma, Dorret I.u Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands4 aut |
700 | 1 | a Christiansen, Mark W.u Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA4 aut |
700 | 1 | a Claringbould, Anniqueu Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands; Oncode Institute, 3521 AL, Utrecht, The Netherlands4 aut |
700 | 1 | a Deelen, Patricku Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands; Oncode Institute, 3521 AL, Utrecht, The Netherlands; Genomics Coordination Center, University Medical Centre Groningen, Groningen, The Netherlands; Department of Genetics, University Medical Centre Utrecht, P.O. Box 85500, 3508 GA, Utrecht, The Netherlands4 aut |
700 | 1 | a Favé, Marie-Julieu Computational Biology, Ontario Institute for Cancer Research, Toronto, ON, Canada4 aut |
700 | 1 | a Frayling, Timothyu Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, UK4 aut |
700 | 1 | a Gharib, Sina A.u Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USA4 aut |
700 | 1 | a Gibson, Gregu School of Biological Sciences, Georgia Tech, Atlanta, GA, USA4 aut |
700 | 1 | a Heijmans, Bastiaan T.u Leiden University Medical Center, Leiden, The Netherlands4 aut |
700 | 1 | a Hemani, Gibranu MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK4 aut |
700 | 1 | a Jansen, Ricku Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands4 aut |
700 | 1 | a Kähönen, Mikau Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland4 aut |
700 | 1 | a Kalnapenkis, Anetteu Estonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia4 aut |
700 | 1 | a Kasela, Silvau Estonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia4 aut |
700 | 1 | a Kettunen, Johannesu University of Helsinki, Helsinki, Finland4 aut |
700 | 1 | a Kim, Yungilu Department of Computer Science, and Departments of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA; Genetics and Genomic Science Department, Icahn School of Medicine at Mount Sinai, New York, NY, USA4 aut |
700 | 1 | a Kirsten, Holgeru Institut für Medizinische InformatiK, Statistik und Epidemiologie, LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany4 aut |
700 | 1 | a Kovacs, Peteru IFB Adiposity Diseases, Universität Leipzig, Leipzig, Germany4 aut |
700 | 1 | a Krohn, Knutu Interdisciplinary Center for Clinical Research, Faculty of Medicine, Universität Leipzig, Leipzig, Germany4 aut |
700 | 1 | a Kronberg, Jaanikau Estonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia4 aut |
700 | 1 | a Kukushkina, Viktorijau Estonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia4 aut |
700 | 1 | a Kutalik, Zoltanu Lausanne University Hospital, Lausanne, Switzerland4 aut |
700 | 1 | a Lee, Bernettu Singapore Immunology Network, Agency for Science Technology and Research, Singapore, Singapore4 aut |
700 | 1 | a Loeffler, Markusu Institut für Medizinische InformatiK, Statistik und Epidemiologie, LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany4 aut |
700 | 1 | a Marigorta, Urko M.u School of Biological Sciences, Georgia Tech, Atlanta, GA, USA; Integrative Genomics Lab, CIC bioGUNE, Bizkaia Science and Technology Park, Derio, Bizkaia, Basque Country, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain4 aut |
700 | 1 | a Mei, Hailangu Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands4 aut |
700 | 1 | a Milani, Liliu Estonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia4 aut |
700 | 1 | a Montgomery, Grant W.u Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia4 aut |
700 | 1 | a Müller-Nurasyid, Martinau Institute of Genetic Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany; Department of Medicine I, University Hospital Munich, Ludwig Maximilian’s University, München, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany4 aut |
700 | 1 | a Nauck, Matthiasu Institute of Clinical Chemistry and Laboratory Medicine, Greifswald University Hospital, Greifswald, Germany; German Center for Cardiovascular Research (partner site Greifswald), Greifswald, Germany4 aut |
700 | 1 | a Nivard, Michel G.u Department of Biological Psychology, Faculty of Behaviour and Movement Sciences, VU, Amsterdam, The Netherlands4 aut |
700 | 1 | a Penninx, Brendau Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands4 aut |
700 | 1 | a Perola, Markusu National Institute for Health and Welfare, University of Helsinki, Helsinki, Finland4 aut |
700 | 1 | a Pervjakova, Nataliau Estonian Genome Centre, Institute of Genomics, University of Tartu, 50090, Tartu, Estonia4 aut |
700 | 1 | a Pierce, Brandon L.u Department of Public Health Sciences, University of Chicago, Chicago, IL, USA4 aut |
700 | 1 | a Powell, Josephu Garvan Institute of Medical Research, Garvan-Weizmann Centre for Cellular Genomics, Sydney, NSW, Australia4 aut |
700 | 1 | a Prokisch, Holgeru Institute of Neurogenomics, Helmholtz Zentrum München, Neuherberg, Germany; Institute of Human Genetics, Technical University Munich, Munich, Germany4 aut |
700 | 1 | a Psaty, Bruce M.u Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA4 aut |
700 | 1 | a Ripatti, Samuliu Statistical and Translational Genetics, University of Helsinki, Helsinki, Finland4 aut |
700 | 1 | a Rotzschke, Olafu Singapore Immunology Network, Agency for Science Technology and Research, Singapore, Singapore4 aut |
700 | 1 | a Rüeger, Sinau Lausanne University Hospital, Lausanne, Switzerland4 aut |
700 | 1 | a Saha, Ashisu Department of Computer Science, and Departments of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA4 aut |
700 | 1 | a Scholz, Markusu Institut für Medizinische InformatiK, Statistik und Epidemiologie, LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany4 aut |
700 | 1 | a Schramm, Katharinau Institute of Genetic Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany; Department of Medicine I, University Hospital Munich, Ludwig Maximilian’s University, München, Germany4 aut |
700 | 1 | a Seppälä, Ilkkau Department of Clinical Chemistry, Fimlab Laboratories and Finnish Centre for Cardiovascular Disease Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33520, Finland4 aut |
700 | 1 | a Slagboom, Eline P.u Leiden University Medical Center, Leiden, The Netherlands4 aut |
700 | 1 | a Stehouwer, Coen D. A.u Department of Internal Medicine and School for Cardiovascular Diseases (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands4 aut |
700 | 1 | a Stumvoll, Michaelu Department of Medicine, Universität Leipzig, Leipzig, Germany4 aut |
700 | 1 | a Sullivan, Patricku Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden4 aut |
700 | 1 | a ‘t Hoen, Peter A. C.u Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands4 aut |
700 | 1 | a Thiery, Joachimu Institute for Laboratory Medicine, LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany4 aut |
700 | 1 | a Tong, Linu Department of Public Health Sciences, University of Chicago, Chicago, IL, USA4 aut |
700 | 1 | a Tönjes, Ankeu German Center for Cardiovascular Research (partner site Greifswald), Greifswald, Germany4 aut |
700 | 1 | a van Dongen, Jennyu Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands4 aut |
700 | 1 | a van Iterson, Maartenu Leiden University Medical Center, Leiden, The Netherlands4 aut |
700 | 1 | a van Meurs, Joyceu Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands4 aut |
700 | 1 | a Veldink, Jan H.u UMC Utrecht Brain Center, University Medical Center Utrecht, Department of Neurology, Utrecht University, Utrecht, The Netherlands4 aut |
700 | 1 | a Verlouw, Joostu Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands4 aut |
700 | 1 | a Visscher, Peter M.u Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia4 aut |
700 | 1 | a Völker, Uweu Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany4 aut |
700 | 1 | a Westra, Harm-Janu Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands; Oncode Institute, 3521 AL, Utrecht, The Netherlands4 aut |
700 | 1 | a Wijmenga, Ciscau Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, The Netherlands4 aut |
700 | 1 | a Yaghootkar, Haniehu Luleå tekniska universitet,Medicinsk vetenskap,Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, UK; School of Life Sciences, College of Liberal Arts and Science, University of Westminster, 115 New Cavendish Street, London, UK4 aut0 (Swepub:ltu)hanyag |
700 | 1 | a Yang, Jianu Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia; School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China4 aut |
700 | 1 | a Zeng, Biaou School of Biological Sciences, Georgia Tech, Atlanta, GA, USA4 aut |
700 | 1 | a Zhang, Futaou Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia4 aut |
700 | 1 | a Epstein, Michael P.u Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA4 aut |
700 | 1 | a Yang, Jingjingu Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA4 aut |
710 | 2 | a Department of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA, 30322, USA; Center for Computational and Quantitative Genetics, Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USAb Program of Computational Biology and Bioinformatics, Yale University, New Haven, CT, 06511, USA4 org |
773 | 0 | t Nature Communicationsd : Springer Natureg 14:1q 14:1x 2041-1723 |
856 | 4 | u https://doi.org/10.1038/s41467-023-36862-wy Fulltext |
856 | 4 | u https://ltu.diva-portal.org/smash/get/diva2:1749339/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-96339 |
856 | 4 8 | u https://doi.org/10.1038/s41467-023-36862-w |
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