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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00009076naa a2200865 4500
001oai:DiVA.org:umu-189150
003SwePub
008211104s2021 | |||||||||||000 ||eng|
009oai:DiVA.org:mau-47867
009oai:lup.lub.lu.se:606c52dd-b9f2-4bd4-9fd5-85548067b5c3
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1891502 URI
0247 a https://doi.org/10.3389/fmed.2021.7215542 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-478672 URI
0247 a https://lup.lub.lu.se/record/606c52dd-b9f2-4bd4-9fd5-85548067b5c32 URI
040 a (SwePub)umud (SwePub)maud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Guo, Jinanu Jinan Univ, Clin Med Coll 2, Shenzhen People S Hosp, Shenzhen, Peoples R China.;Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China.;Shenzhen Urol Minimally Invas Engn Ctr, Shenzhen, Peoples R China.;Clin Med Res Ctr, Shenzhen Publ Serv Platform Tumor Precis Med & Mo, Shenzhen, Peoples R China.,Jinan University4 aut
2451 0a Non-invasive Urine Test for Molecular Classification of Clinical Significance in Newly Diagnosed Prostate Cancer Patients
264 c 2021-09-14
264 1b Frontiers Media S.A.c 2021
338 a electronic2 rdacarrier
520 a Objective: To avoid over-treatment of low-risk prostate cancer patients, it is important to identify clinically significant and insignificant cancer for treatment decision-making. However, no accurate test is currently available.Methods: To address this unmet medical need, we developed a novel gene classifier to distinguish clinically significant and insignificant cancer, which were classified based on the National Comprehensive Cancer Network risk stratification guidelines. A non-invasive urine test was developed using quantitative mRNA expression data of 24 genes in the classifier with an algorithm to stratify the clinical significance of the cancer. Two independent, multicenter, retrospective and prospective studies were conducted to assess the diagnostic performance of the 24-Gene Classifier and the current clinicopathological measures by univariate and multivariate logistic regression and discriminant analysis. In addition, assessments were performed in various Gleason grades/ISUP Grade Groups.Results: The results showed high diagnostic accuracy of the 24-Gene Classifier with an AUC of 0.917 (95% CI 0.892-0.942) in the retrospective cohort (n = 520), AUC of 0.959 (95% CI 0.935-0.983) in the prospective cohort (n = 207), and AUC of 0.930 (95% 0.912-CI 0.947) in the combination cohort (n = 727). Univariate and multivariate analysis showed that the 24-Gene Classifier was more accurate than cancer stage, Gleason score, and PSA, especially in the low/intermediate-grade/ISUP Grade Group 1-3 cancer subgroups.Conclusions: The 24-Gene Classifier urine test is an accurate and non-invasive liquid biopsy method for identifying clinically significant prostate cancer in newly diagnosed cancer patients. It has the potential to improve prostate cancer treatment decisions and active surveillance.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologi0 (SwePub)3042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Medical Biotechnology0 (SwePub)3042 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
653 a active surveillance
653 a clinically significant prostate cancer
653 a gene panel
653 a liquid biopsy
653 a prostate cancer
653 a prostate cancer risk
653 a urine test
653 a medicin
653 a Medicine
653 a active surveillance
653 a clinically significant prostate cancer
653 a gene panel
653 a liquid biopsy
653 a prostate cancer
653 a prostate cancer risk
653 a urine test
7001 a Zhang, Xuhuiu Inst Basic Med Sci, Dept Biodiag, Beijing, Peoples R China.,Beijing Institute of Basic Medical Sciences4 aut
7001 a Xia, Taolinu Foshan First Peoples Hosp, Dept Urol, Foshan, Peoples R China.,Foshan First People’s Hospital4 aut
7001 a Johnson, Heatheru Olympia Diagnost Inc, Sunnyvale, CA USA.,Olympia Diagnostics Inc.4 aut
7001 a Feng, Xiaoyanu Inst Basic Med Sci, Dept Biodiag, Beijing, Peoples R China.,Beijing Institute of Basic Medical Sciences4 aut
7001 a Simoulis, Athanasiosu Skane Univ Hosp, Dept Clin Pathol & Cytol, Malmo, Sweden.,Skåne University Hospital4 aut0 (Swepub:lu)at5550si
7001 a Wu, Alan H. B.u San Francisco Gen Hosp, Clin Labs, San Francisco, CA 94110 USA.,San Francisco General Hospital4 aut
7001 a Li, Feiu Southern Med Univ, Nanfang Hosp, Dept Urol, Guangzhou, Peoples R China.,Southern Medical University4 aut
7001 a Tan, Wanlongu Southern Med Univ, Nanfang Hosp, Dept Urol, Guangzhou, Peoples R China.,Southern Medical University4 aut
7001 a Johnson, Allanu Kinet Real, Santa Clara, CA USA.,Kinetic Reality4 aut
7001 a Dizeyi, Nishtmanu Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Urologi, Malmö (Abrahamsson),Forskargrupper vid Lunds universitet,Department of Translational Medicine,Faculty of Medicine,Urological research, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)kir-dni
7001 a Abrahamsson, Per Andersu Lund University,Lunds universitet,Urologi, Malmö (Abrahamsson),Forskargrupper vid Lunds universitet,Urological research, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)uro-paa
7001 a Kenner, Lukasu Med Univ Vienna, Dept Expt Pathol, Vienna, Austria.;Univ Vet Med, Unit Lab Anim Pathol, Vienna, Austria.,Medical University of Vienna4 aut
7001 a Xiao, Kefengu Jinan Univ, Clin Med Coll 2, Shenzhen People S Hosp, Shenzhen, Peoples R China.;Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China.;Shenzhen Urol Minimally Invas Engn Ctr, Shenzhen, Peoples R China.;Clin Med Res Ctr, Shenzhen Publ Serv Platform Tumor Precis Med & Mo, Shenzhen, Peoples R China.,Jinan University4 aut
7001 a Zhang, Heqiuu Inst Basic Med Sci, Dept Biodiag, Beijing, Peoples R China.,Beijing Institute of Basic Medical Sciences4 aut
7001 a Chen, Lingwuu Sun Yat Sen Univ, Affiliated Hosp 1, Dept Urol, Guangzhou, Peoples R China.,First Affiliated Hospital of Sun Yat-sen University4 aut
7001 a Zou, Changu Jinan Univ, Clin Med Coll 2, Shenzhen People S Hosp, Shenzhen, Peoples R China.;Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China.;Shenzhen Urol Minimally Invas Engn Ctr, Shenzhen, Peoples R China.;Clin Med Res Ctr, Shenzhen Publ Serv Platform Tumor Precis Med & Mo, Shenzhen, Peoples R China.;Southwest Med Univ, Sch Pharm, Educ Minist, Key Lab Med Electrophysiol, Luzhou, Peoples R China.,Jinan University4 aut
7001 a Persson, Jenny L.,c Professoru Umeå University,Malmö University,Malmö universitet,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Biomedical Sciences, Malmö University, Malmö, Sweden; Division of Experimental Cancer Research, Department of Translational Medicine, Lund University, Malmö, Sweden,Institutionen för biomedicinsk vetenskap (BMV),Umea Univ, Dept Mol Biol, Umea, Sweden.; Lund Univ, Dept Translat Med, Div Expt Canc Res, Malmo, Sweden.4 aut0 (Swepub:lu)medk-jpe
7102 a Jinan Univ, Clin Med Coll 2, Shenzhen People S Hosp, Shenzhen, Peoples R China.;Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China.;Shenzhen Urol Minimally Invas Engn Ctr, Shenzhen, Peoples R China.;Clin Med Res Ctr, Shenzhen Publ Serv Platform Tumor Precis Med & Mo, Shenzhen, Peoples R China.b Jinan University4 org
7730 t Frontiers in Medicined : Frontiers Media S.A.g 8q 8x 2296-858X
8564 u https://doi.org/10.3389/fmed.2021.721554y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1608895/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://www.frontiersin.org/articles/10.3389/fmed.2021.721554/pdf
8564 u https://mau.diva-portal.org/smash/get/diva2:1620635/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u http://dx.doi.org/10.3389/fmed.2021.721554x freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-189150
8564 8u https://doi.org/10.3389/fmed.2021.721554
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-47867
8564 8u https://lup.lub.lu.se/record/606c52dd-b9f2-4bd4-9fd5-85548067b5c3

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