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von Willebrand disease update: diagnostic and treatment dilemmas
- Bolton-Maggs, P H B (author)
- Lillicrap, D (author)
- Goudemand, J (author)
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- (creator_code:org_t)
- Wiley, 2008
- 2008
- English.
- In: Haemophilia. - : Wiley. - 1351-8216 .- 1365-2516. ; 14:s3, s. 56-61
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Although von Willebrand disease (VWD) is now well-described, many facets of diagnosis and management continue to be debated. The diagnosis of type 1 disease can be difficult but recent genetic analyses help to distinguish many factors which can influence von Willebrand factor (VWF) levels and bleeding phenotype. Type 2 disease (functional abnormalities) includes a particularly interesting group of disorders with faulty binding between VWF and FVIIIC (Normandy) where treatment methods need careful consideration. Type 3 VWD is the most severe form of VWD and a new international study is underway to examine the use of prophylaxis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- diagnosis
- molecular genetics
- prophylaxis study
- VWD
- VWD type 3
- VWD Normandy
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- art (subject category)
- ref (subject category)
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- Bolton-Maggs, P ...
- Lillicrap, D
- Goudemand, J
- Berntorp, Erik
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
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- and Hematology
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- Haemophilia
- By the university
- Lund University
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