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3D nanoscale analysis of bone healing around degrading Mg implants evaluated by X-ray scattering tensor tomography

Liebi, Marianne, 1984 (författare)
Eidgenössische Materialprüfungs- und Forschungsanstalt (Empa),Swiss Federal Laboratories for Materials Science and Technology (Empa),Chalmers tekniska högskola,Chalmers University of Technology,Paul Scherrer Institut
Lutz-Bueno, Viviane (författare)
Paul Scherrer Institut
Guizar-Sicairos, Manuel (författare)
Paul Scherrer Institut
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Schönbauer, Bernd M. (författare)
Universität für Bodenkultur,University of Natural Resources and Life Sciences
Eichler, Johannes (författare)
Medizinische Universität Graz,Medical University of Graz
Martinelli, Elisabeth (författare)
Medizinische Universität Graz,Medical University of Graz
Löffler, Jörg F. (författare)
Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH)
Weinberg, Annelie (författare)
Medizinische Universität Graz,Medical University of Graz
Lichtenegger, Helga (författare)
Universität für Bodenkultur,University of Natural Resources and Life Sciences
Grünewald, Tilman A. (författare)
European Synchrotron Radiation Facility (ESRF)
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 (creator_code:org_t)
Elsevier BV, 2021
2021
Engelska.
Ingår i: Acta Biomaterialia. - : Elsevier BV. - 1878-7568 .- 1742-7061. ; 134, s. 804-817
Relaterad länk:
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The nanostructural adaptation of bone is crucial for its biocompatibility with orthopedic implants. The bone nanostructure also determines its mechanical properties and performance. However, the bone's temporal and spatial nanoadaptation around degrading implants remains largely unknown. Here, we present insights into this important bone adaptation by applying scanning electron microscopy, elemental analysis, and small-angle X-ray scattering tensor tomography (SASTT). We extend the novel SASTT reconstruction method and provide a 3D scattering reciprocal space map per voxel of the sample's volume. From this reconstruction, parameters such as the thickness of the bone mineral particles are quantified, which provide additional information on nanostructural adaptation of bone during healing. We selected a rat femoral bone and a degrading ZX10 magnesium implant as model system, and investigated it over the course of 18 months, using a sham as control. We observe that the bone's nanostructural adaptation starts with an initially fast interfacial bone growth close to the implant, which spreads by a re-orientation of the nanostructure in the bone volume around the implant, and is consolidated in the later degradation stages. These observations reveal the complex bulk bone-implant interactions and enable future research on the related biomechanical bone responses. Statement of significance: Traumatic bone injuries are among the most frequent causes of surgical treatment, and often require the placement of an implant. The ideal implant supports and induces bone formation, while being mechanically and chemically adapted to the bone structure, ensuring a gradual load transfer. While magnesium implants fulfill these requirements, the nanostructural changes during bone healing and implant degradation remain not completely elucidated. Here, we unveil these processes in rat femoral bones with ZX10 magnesium implants and show different stages of bone healing in such a model system.

Ämnesord

TEKNIK OCH TEKNOLOGIER  -- Industriell bioteknik -- Biomaterial (hsv//swe)
ENGINEERING AND TECHNOLOGY  -- Industrial Biotechnology -- Bio Materials (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
TEKNIK OCH TEKNOLOGIER  -- Medicinteknik -- Medicinsk material- och protesteknik (hsv//swe)
ENGINEERING AND TECHNOLOGY  -- Medical Engineering -- Medical Materials (hsv//eng)

Nyckelord

Tomography
X-ray scattering
Biomineralization
Degradable magnesium implants
Implant degradation

Publikations- och innehållstyp

art (ämneskategori)
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