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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008631naa a2200577 4500
001oai:lup.lub.lu.se:260d917a-8484-4125-8903-2a76b0e06ad2
003SwePub
008240226| | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/260d917a-8484-4125-8903-2a76b0e06ad22 URI
0247 a https://doi.org/10.1038/s41591-024-02869-z2 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Barthélemy, Nicolas Ru Washington University School of Medicine4 aut
2451 0a Highly Accurate Blood Test for Alzheimer's Disease Comparable or Superior to Clinical CSF Tests
300 a 42 s.
520 a With the emergence of Alzheimer's disease (AD) disease-modifying therapies, identifying patients who could benefit from these treatments becomes critical. We evaluated whether a precise blood test could perform as well as established cerebrospinal fluid (CSF) tests in detecting amyloid-β (Aβ) plaques and tau tangles. Plasma %p-tau217 (ratio of phosporylated-tau217 to non-phosphorylated tau) was analyzed by mass spectrometry in the Swedish BioFINDER-2 cohort (n=1,422) and the US Knight ADRC cohort (n=337). Matched CSF samples were analyzed with clinically used and FDA-approved automated immunoassays for Aβ42/40 and p-tau181/Aβ42. The primary and secondary outcomes were detection of brain Aβ or tau pathology, respectively, using PET imaging as the reference standard. Main analyses were focused on individuals with cognitive impairment (mild cognitive impairment and mild dementia), which is the target population for available disease-modifying treatments. Plasma %p-tau217 was clinically equivalent to FDA-approved CSF tests in classifying Aβ PET status, with an area-under-the-curve (AUC) for both between 0.95-0.97. Plasma %p-tau217 was generally superior to CSF tests in classification of tau-PET with AUCs of 0.95-0.98. In cognitively impaired sub-cohorts (BioFINDER-2: n=720; Knight ADRC: n=50), plasma %p-tau217 had an accuracy, positive predictive value and negative predictive value of 89-90% for Aβ PET and 87-88% for tau-PET status, which was clinically equivalent to CSF tests, further improving to 95% using a two cut-off approach. Blood plasma %p-tau217 demonstrated performance clinically equivalent or superior to clinically used FDA-approved CSF tests in the detection of AD pathology. Use of high performance blood tests in clinical practice can improve access to accurate AD diagnosis and AD-specific treatments.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653 a Alzheimer's disease
653 a Diagnosis
653 a Diagnostic markers
7001 a Salvadó, Gemmau Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas4 aut0 (Swepub:lu)ge5655sa
7001 a Schindler, Suzanneu Washington University School of Medicine4 aut
7001 a He, Yingxinu Washington University School of Medicine4 aut
7001 a Janelidze, Shorenau Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas4 aut0 (Swepub:lu)nkir-sje
7001 a Collij, Lyduine Eu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Amsterdam UMC - Vrije Universiteit Amsterdam,Amsterdam Neuroscience4 aut0 (Swepub:lu)ly4120co
7001 a Saef, Benjaminu Washington University School of Medicine4 aut
7001 a Henson, Rachel Lu Washington University School of Medicine4 aut
7001 a Chen, Charles Du Washington University School of Medicine4 aut
7001 a Gordon, Brian Au Washington University School of Medicine4 aut
7001 a Li, Yanu CRO (Centro di Riferimento Oncologico) Aviano National Cancer Institute,Washington University in St. Louis4 aut
7001 a La Joie, Renaudu University of California System4 aut
7001 a Benzinger, Tammie L Su Washington University School of Medicine4 aut
7001 a Morris, John Cu Washington University School of Medicine4 aut
7001 a Mattsson-Carlgren, Niklasu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital4 aut0 (Swepub:lu)med-nmn
7001 a Palmqvist, Sebastianu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital4 aut0 (Swepub:lu)med-spa
7001 a Ossenkoppele, Riku Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Amsterdam UMC - Vrije Universiteit Amsterdam,Amsterdam Neuroscience4 aut0 (Swepub:lu)ri1513os
7001 a Rabinovici, Gil Du University of California System4 aut
7001 a Stomrud, Eriku Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital4 aut0 (Swepub:lu)med-esr
7001 a Bateman, Randall Ju Washington University School of Medicine4 aut
7001 a Hansson, Oskaru Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital4 aut0 (Swepub:lu)mphy-ohn
7102 a Washington University School of Medicineb Institutionen för kliniska vetenskaper, Malmö4 org
7730 t Nature Medicinex 1546-170X
8564 u http://dx.doi.org/10.1038/s41591-024-02869-zy FULLTEXT
8564 8u https://lup.lub.lu.se/record/260d917a-8484-4125-8903-2a76b0e06ad2
8564 8u https://doi.org/10.1038/s41591-024-02869-z

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