WFRF:(Jans A.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02497naa a2200361 4500 | |
| 001 | oai:DiVA.org:sh-6066 | |
| 003 | SwePub | |
| 008 | 110207s2002 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-60662 URI |
| 040 | a (SwePub)sh | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a vet2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Brooks, Andrew J4 aut |
| 245 | 1 0 | a The Interdomain Region of Dengue NS5 ProteinInteracts with NS3 and Host Proteins |
| 264 | 1 | c 2002 |
| 338 | a print2 rdacarrier | |
| 520 | a Although dengue virus genome replication occurs in the cytoplasm of infected cells, it has been shown that the NS5 protein (RNA-dependent RNA polymerase) is hyperphosphorylated at a late stage in infection and localized to the cell nucleus. A 37 amino acid sequence of NS5 (residues 369-405) was shown to contain a functional nuclear localization signal (NLS) that interacted with the cellular nuclear transport factor, importin α/β heterodimer. Further studies using the yeast two-hybrid system revealed that the NS5 region (residues 320-368) immediately adjacent to the NLS contained an importin β-binding site that abuts or overlaps the binding site for the NS3 protein (protease/helicase). The importin β-binding site has also been shown to be a functional NLS (bNLS). Intriguingly, when both bNLS and NLS (residues 320-405) were present, the fused β -galactosidase protein did not accumulate in the nucleus. Here we provide a review of our studies on the NS5 interdomain region and compare it to other members of the Flavivirus genus in order to highlight the importance of this region as a possible target for developing broad-acting antiviral agent against dengue and other mechanistically-related viruses. | |
| 653 | a NS5 protein | |
| 653 | a protein interactions | |
| 653 | a NS3 protein | |
| 653 | a nuclear localization signal | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Johansson, Magnusu Södertörns högskola,Avdelning Naturvetenskap4 aut0 (Swepub:sh)shmsjn02 |
| 700 | 1 | a Criswell, Erin4 aut |
| 700 | 1 | a Jans, David A4 aut |
| 700 | 1 | a Vasudevan, Subhash G4 aut |
| 710 | 2 | a Södertörns högskolab Avdelning Naturvetenskap4 org |
| 773 | 0 | t Dengue Bulleting 26, s. 155-161q 26<155-161x 1020-895X |
| 856 | 4 | u http://www.searo.who.int/LinkFiles/Dengue_Bulletin_Volume_26_chap19.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-6066 |
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