SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Kotova Anna)
 

Sökning: WFRF:(Kotova Anna) > Secondary ossificat...

Secondary ossification center induces and protects growth plate structure

Xie, Meng (författare)
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Gol'din, Pavel (författare)
Department of Evolutionary Morphology, Schmalhausen Institute of Zoology of NAS of Ukraine, Ukraine
Nele Herdina, Anna (författare)
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
visa fler...
Estefa, Jordi, 1987- (författare)
Uppsala universitet,Institutionen för organismbiologi
Medvedeva, Ekaterina (författare)
Division of Anatomy, MIC, Medical University of Vienna, Austria,Institute for Regenerative Medicine, Sechenov University, Russia
Li, Lei (författare)
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Newton, Phillip (författare)
Department of Women’s and Children’s Health, Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Sweden,Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Kotova, Svetlana (författare)
Semenov Institute of Chemical Physics, Russia,Institute for Regenerative Medicine, Sechenov University, Russia
Shavkuta, Boris (författare)
Institute of Photonic Technologies, Research center "Crystallography and Photonics", Russia,Institute for Regenerative Medicine, Sechenov University, Russia
Saxena, Aditya (författare)
Division of Biological Sciences, University of California San Diego, USA
Shumate, Lauren (författare)
Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, U.S.A.
Metscher, Brian (författare)
Department of Theoretical Biology, University of Vienna, Austria
Grossschmidt, Karl (författare)
Bone and Biomaterials Research, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria
Nishimori, Shigeki (författare)
Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, U.S.A.
Akovantseva, Anastasia (författare)
Institute of Photonic Technologies, Research center "Crystallography and Photonics", Russia,Institute for Regenerative Medicine, Sechenov University, Russia
Linares Arregui, Irene (författare)
Department of Solid Mechanics, KTH Royal Institute of Technology, Stockholm, Sweden
Tafforeau, Paul (författare)
European Synchrotron Radiation Facility, Grenoble, France
Fried, Kaj (författare)
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
Carlström, Mattias (författare)
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Simon, Andras (författare)
Department of Cell and Molecular Biology, Centre of Developmental Biology for Regenerative Medicine, Karolinska Institute, Stockholm, Sweden
Gasser, Christian (författare)
Department of Solid Mechanics, KTH Royal Institute of Technology, Stockholm, Sweden
Kronenberg, Henry (författare)
Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, U.S.A.
Bastepe, Murat (författare)
Endocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, U.S.A.
Cooper, Kimberly (författare)
Division of Biological Sciences, University of California San Diego, USA
Timashev, Peter (författare)
Semenov Institute of Chemical Physics, Russia,Institute for Regenerative Medicine, Sechenov University, Russia
Sanchez, Sophie (författare)
Uppsala universitet,Institutionen för organismbiologi
Adameyko, Igor (författare)
Department of Molecular Neurosciences, Medical University of Vienna, Austria,Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Eriksson, Anders (författare)
Department of Mechanics, KTH Royal Institute of Technology, Stockholm, Sweden
Chagin, Andrei (författare)
Institute for Regenerative Medicine, Sechenov University, Russia,Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
visa färre...
 (creator_code:org_t)
Engelska.
Ingår i: eLIFE. - 2050-084X.
Relaterad länk:
https://urn.kb.se/re...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Growth plate and articular cartilage constitute a single anatomical entity, but later separate into two distinct structures by the formation of secondary ossification center (SOC). The reason for such spatial separation remains unknown. Here, we demonstrate that evolutionarily SOC first appears in amniotes. Mathematical modelling reveals that SOC reduces mechanical stress within the growth plate. Analysis of mammals with specialized extremities reveals that SOC size correlates with the extent of mechanical demands. Ex and in vivo experiments demonstrate that SOC allows epiphyseal chondrocytes to withstand a several-fold higher load before activation of the YAP-p73 signalling pathway and caspase-dependent apoptosis, with hypertrophic chondrocytes being the most load-sensitive cells. Atomic force microscopy shows  that hypertrophic chondrocytes are the least mechanically stiff cells within the growth plate. Altogether, these findings suggest that SOC is evolved to protect epiphyseal chondrocytes, especially the hypertrophic chondrocytes, from the high mechanical stress encountered in the terrestrial environment.

Ämnesord

NATURVETENSKAP  -- Biologi -- Evolutionsbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Evolutionary Biology (hsv//eng)

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

  • eLIFE (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy