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  • Naguib, MahmoudUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi (author)

A Comparison of Host Responses to Infection with Wild-Type Avian Influenza Viruses in Chickens and Tufted Ducks

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • American Society for Microbiology,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:lnu-123579
  • https://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-123579URI
  • https://doi.org/10.1128/spectrum.02586-22DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-519125URI
  • https://gup.ub.gu.se/publication/328336URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Cross-species transmission of influenza A virus (IAV) from wild waterfowl to poultry is the first step in a chain of events that can ultimately lead to exposure and infection of humans. Herein, we study the outcome of infection with eight different mallard-origin IAV subtypes in two different avian hosts: tufted ducks and chickens. We found that infection and shedding patterns as well as innate immune responses were highly dependent on viral subtypes, host species, and inoculation routes. For example, intraoesophageal inoculation, commonly used in mallard infection experiments, resulted in no infections in contrast to oculonasal inoculation, suggesting a difference in transmission routes. Despite H9N2 being endemic in chickens, inoculation of mallard-origin H9N2 failed to cause viable infection beyond 1 day postinfection in our study design. The innate immune responses were markedly different in chickens and tufted ducks, and despite the presence of retinoic acid-inducible gene-I (RIG-I) in tufted duck transcriptomes, it was neither up nor downregulated in response to infection. Overall, we have revealed the heterogeneity of infection patterns and responses in two markedly different avian hosts following a challenge with mallard-origin IAV. These virus-host interactions provide new insights into important aspects of interspecies transmission of IAV.IMPORTANCE Our current findings highlight important aspects of IAV infection in birds that have implications for our understanding of its zoonotic ecology. In contrast to mallards where the intestinal tract is the main site of IAV replication, chickens and tufted ducks show limited or no signs of intestinal infection suggesting that the fecal-oral transmission route might not apply to all bird IAV host species. Our results indicate that mallard-origin IAVs undergo genetic changes upon introduction into new hosts, suggesting rapid adaptation to a new environment. However, similar to the mallard, chickens and tufted ducks show a limited immune response to infection with low pathogenic avian influenza viruses. These findings and future studies in different IAV hosts are important for our understanding of barriers to IAV transmission between species and ultimately from the wild reservoir to humans. Our current findings highlight important aspects of IAV infection in birds that have implications for our understanding of its zoonotic ecology. In contrast to mallards where the intestinal tract is the main site of IAV replication, chickens and tufted ducks show limited or no signs of intestinal infection suggesting that the fecal-oral transmission route might not apply to all bird IAV host species.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Eriksson, PerUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)perer797 (author)
  • Jax, ElinorMax Planck Inst Anim Behav, Germany;Univ Konstanz, Germany,Department of Migration, Max Planck Institute of Animal Behavior, Radolfzell, Germany;Department of Biology, University of Konstanz, Konstanz, Germany (author)
  • Wille, MichelleUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)micwi695 (author)
  • Lindskog, CeciliaUppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerprecisionsmedicin(Swepub:uu)cecli129 (author)
  • Bröjer, CarolineDepartment of Pathology and Wildlife Diseases, National Veterinary Institute (SVA), Uppsala, Sweden (author)
  • Krambrich, JaninaUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)jankr830 (author)
  • Waldenström, Jonas,1975-Linnéuniversitetet,Institutionen för biologi och miljö (BOM),Ctr Ecol & Evolut Microbial Model Syst EEMiS,Centre for Ecology and Evolution in Microbial Model Systems, Linnaeus University, Kalmar, Sweden(Swepub:lnu)ewajo (author)
  • Kraus, Robert H. S.Max Planck Inst Anim Behav, Germany;Univ Konstanz, Germany,Department of Migration, Max Planck Institute of Animal Behavior, Radolfzell, Germany;Department of Biology, University of Konstanz, Konstanz, Germany (author)
  • Larson, Göran,1953Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för laboratoriemedicin,Department of Laboratory Medicine(Swepub:gu)xlarsg (author)
  • Lundkvist, ÅkeUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)akelu185 (author)
  • Olsen, BjörnUppsala universitet,Infektionsmedicin(Swepub:uu)bjool781 (author)
  • Järhult, Josef D.,1975-Uppsala universitet,Infektionsmedicin(Swepub:uu)josja939 (author)
  • Ellström, PatrikUppsala universitet,Infektionsmedicin,Klinisk mikrobiologi(Swepub:uu)patel687 (author)
  • Uppsala universitetInstitutionen för medicinsk biokemi och mikrobiologi (creator_code:org_t)

Related titles

  • In:Microbiology Spectrum: American Society for Microbiology11:42165-0497

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