Pulmonary manifestations of systemic karyomegaly

Nicholson, Andrew G. (författare): Imperial Coll, England; Imperial Coll, England

Mauritz, Nils-Johan (författare): Linköpings universitet,Institutionen för medicin och hälsa,Medicinska fakulteten,Department of Nephrology, Jönköping, Region Jönköping County, Sweden

(creator_code:org_t)

ELSEVIER, 2020
2020
Engelska.
Ingår i: RESPIRATORY MEDICINE CASE REPORTS. - : ELSEVIER. - 2213-0071. ; 29

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Abstract Ämnesord

Stäng

Over 40 years ago, abnormal enlargement of the nucleus of tubular epithelial cells was reported in a rare distinct hereditary chronic interstitial nephritis, karyomegalic interstitial nephritis (KIN). Here, we report the second case of systemic karyomegaly with pulmonary manifestations and present a detailed characterization of the karyomegalic cells in lung parenchyma. A 59-year-old woman who was diagnosed with KIN developed renal failure and eventually received a renal transplant later evaluated for chronic and progressive restrictive lung disease. The KIN diagnosis prompted us to carefully examine her lung parenchyma. Karyomegalic cells were identified in the alveolar epithelium, interstitium, as well as, in the vascular wall. Viral serological and biochemical blood analyses were negative. We consider that the pulmonary manifestations of karyomegaly expands the differential diagnosis of interstitial lung disease in patients with KIN.

Av författaren/redakt...: Akyurek, Levent ...; Hussein, Aziz; Nicholson, Andre ...; Mauritz, Nils-Jo ...; Molne, Johan

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Lungmedicin och ...

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